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Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury.

Abstract

BACKGROUND

Electromyographic studies have shown that external anal sphincter activity is modified in response to distension in animals with spinal cord injury. Gonadotropin-releasing hormone and its agonist leuprolide acetate have neurotrophic properties in animals with spinal cord injury.

AIM

This study was to determine the effects of leuprolide acetate treatment on electromyographic activity of the external anal sphincter and anorectal manometry in ovariectomized rats with spinal cord injury.

METHODS

Adult ovariectomized rats were divided in three groups: (a) sham of spinal cord injury, (b) spinal cord injury treated with saline solution, and (c) spinal cord injury treated with leuprolide acetate. The spinal cord injury was induced by clamping at level T9. Leuprolide acetate dosage of 10 μg/kg was proctored intramuscular for 5 weeks, commencing the day after the lesion. Electromyography of the external anal sphincter, anorectal manometry, and volume of the cecum were evaluated in all groups.

RESULTS

The electromyographic study of the external anal sphincter activity showed a significant improvement in injured rats treated with leuprolide acetate. Manometric analysis and cecum volume data obtained in animals with leuprolide acetate were very similar to those found in the sham group.

CONCLUSIONS

These results demonstrate that leuprolide acetate treatment improves the neurogenic colon in ovariectomized rats with spinal cord injury.

Authors+Show Affiliations

Laboratorio de Neurofisiología, Depto. de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ciudad Universitaria, C.P. 20131, Aguascalientes Ags., Mexico.Laboratorio de Neurofisiología, Depto. de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ciudad Universitaria, C.P. 20131, Aguascalientes Ags., Mexico.Centro Tlaxcala de Biología de la Conducta, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico.Depto. de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.Division of Pathology, Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada.Division of Pathology, Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada.Laboratorio de Neurofisiología, Depto. de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ciudad Universitaria, C.P. 20131, Aguascalientes Ags., Mexico. jlquinta@correo.uaa.mx.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31471861

Citation

Altamira-Camacho, Moisés, et al. "Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats With Spinal Cord Injury." Digestive Diseases and Sciences, 2019.
Altamira-Camacho M, Medina-Aguiñaga D, Cruz Y, et al. Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury. Dig Dis Sci. 2019.
Altamira-Camacho, M., Medina-Aguiñaga, D., Cruz, Y., Calderón-Vallejo, D., Kovacs, K., Rotondo, F., & Quintanar, J. L. (2019). Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury. Digestive Diseases and Sciences, doi:10.1007/s10620-019-05783-4.
Altamira-Camacho M, et al. Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats With Spinal Cord Injury. Dig Dis Sci. 2019 Aug 20; PubMed PMID: 31471861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury. AU - Altamira-Camacho,Moisés, AU - Medina-Aguiñaga,Daniel, AU - Cruz,Yolanda, AU - Calderón-Vallejo,Denisse, AU - Kovacs,Kalman, AU - Rotondo,Fabio, AU - Quintanar,J Luis, Y1 - 2019/08/20/ PY - 2018/11/06/received PY - 2019/08/07/accepted PY - 2019/9/1/entrez KW - Cecum KW - Electromyography KW - External anal sphincter KW - GnRH KW - Neuroregeneration KW - SCI JF - Digestive diseases and sciences JO - Dig. Dis. Sci. N2 - BACKGROUND: Electromyographic studies have shown that external anal sphincter activity is modified in response to distension in animals with spinal cord injury. Gonadotropin-releasing hormone and its agonist leuprolide acetate have neurotrophic properties in animals with spinal cord injury. AIM: This study was to determine the effects of leuprolide acetate treatment on electromyographic activity of the external anal sphincter and anorectal manometry in ovariectomized rats with spinal cord injury. METHODS: Adult ovariectomized rats were divided in three groups: (a) sham of spinal cord injury, (b) spinal cord injury treated with saline solution, and (c) spinal cord injury treated with leuprolide acetate. The spinal cord injury was induced by clamping at level T9. Leuprolide acetate dosage of 10 μg/kg was proctored intramuscular for 5 weeks, commencing the day after the lesion. Electromyography of the external anal sphincter, anorectal manometry, and volume of the cecum were evaluated in all groups. RESULTS: The electromyographic study of the external anal sphincter activity showed a significant improvement in injured rats treated with leuprolide acetate. Manometric analysis and cecum volume data obtained in animals with leuprolide acetate were very similar to those found in the sham group. CONCLUSIONS: These results demonstrate that leuprolide acetate treatment improves the neurogenic colon in ovariectomized rats with spinal cord injury. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/31471861/Leuprolide_Acetate,_a_GnRH_Agonist,_Improves_the_Neurogenic_Bowel_in_Ovariectomized_Rats_with_Spinal_Cord_Injury L2 - https://doi.org/10.1007/s10620-019-05783-4 DB - PRIME DP - Unbound Medicine ER -