Tags

Type your tag names separated by a space and hit enter

Clinical, biochemical and gender characteristics of 97 prepubertal children with premature adrenarche.
J Pediatr Endocrinol Metab 2019; 32(11):1247-1252JP

Abstract

Background Premature adrenarche (PA) is defined as the appearance of clinical signs of androgen action associated with levels of dehydroepiandrosterone sulfate (DHEAS) ≥40 μg/dL, before age 8 years in girls and 9 years in boys, without breast or testicular enlargement. The aim of this study was to characterize a population of prepubertal Caucasian children with PA and to compare them with regard to gender and body mass index (BMI) (normal BMI vs. overweight/obesity). Methods We performed a cross-sectional study of Portuguese Caucasian prepubertal children followed, due to PA, in pediatric endocrinology clinics of a university hospital. Results Eighty-two girls and 15 boys were included (mean age at evaluation: 7.4 ± 1.3 years). The mean birth weight was 2990 ± 689 g; only two children were small for gestational age. Girls presented premature pubarche at a younger age (median [interquartile range (IQR)] 6 (5-6) years vs. 7 (7-8) years in boys; p < 0.001). No gender differences were found for gestational age, birth weight, maternal age at menarche, anthropometry, bone age advancement or androgen levels. The majority of the subjects were overweight or obese (59%). Overweight/obese PA children were taller and had a more advanced bone age than normal-BMI PA children. Overweight/obese children presented higher levels of DHEAS and androstenedione. Bone age advancement and DHEAS were correlated (r = 0.449; p = 0.05). Conclusions We found no evidence of reduced fetal growth. Girls presented premature pubarche at a younger age. No major gender differences in androgen levels were found in prepuberty. Obese and overweight PA children tend to be taller, have a more advanced bone age and higher levels of androgens than normal-BMI PA children.

Authors+Show Affiliations

Pediatric Endocrinology and Diabetology Unit, Department of Pediatrics, Centro Hospitalar Universitário de S. João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal. Faculdade de Medicina da Universidade do Porto, Porto, Portugal.Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Pediatric Endocrinology and Diabetology Unit, Department of Pediatrics, Centro Hospitalar Universitário de S. João, Porto, Portugal.Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Pediatric Endocrinology and Diabetology Unit, Department of Pediatrics, Centro Hospitalar Universitário de S. João, Porto, Portugal.Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Pediatric Endocrinology and Diabetology Unit, Department of Pediatrics, Centro Hospitalar Universitário de S. João, Porto, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31472065

Citation

Santos-Silva, Rita, et al. "Clinical, Biochemical and Gender Characteristics of 97 Prepubertal Children With Premature Adrenarche." Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 32, no. 11, 2019, pp. 1247-1252.
Santos-Silva R, Costa C, Castro-Correia C, et al. Clinical, biochemical and gender characteristics of 97 prepubertal children with premature adrenarche. J Pediatr Endocrinol Metab. 2019;32(11):1247-1252.
Santos-Silva, R., Costa, C., Castro-Correia, C., & Fontoura, M. (2019). Clinical, biochemical and gender characteristics of 97 prepubertal children with premature adrenarche. Journal of Pediatric Endocrinology & Metabolism : JPEM, 32(11), pp. 1247-1252. doi:10.1515/jpem-2019-0185.
Santos-Silva R, et al. Clinical, Biochemical and Gender Characteristics of 97 Prepubertal Children With Premature Adrenarche. J Pediatr Endocrinol Metab. 2019 Nov 26;32(11):1247-1252. PubMed PMID: 31472065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical, biochemical and gender characteristics of 97 prepubertal children with premature adrenarche. AU - Santos-Silva,Rita, AU - Costa,Carla, AU - Castro-Correia,Cíntia, AU - Fontoura,Manuel, PY - 2019/04/18/received PY - 2019/07/15/accepted PY - 2019/9/1/pubmed PY - 2019/9/1/medline PY - 2019/9/1/entrez KW - adrenarche KW - dehydroepiandrosterone sulfate KW - premature pubarche SP - 1247 EP - 1252 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. VL - 32 IS - 11 N2 - Background Premature adrenarche (PA) is defined as the appearance of clinical signs of androgen action associated with levels of dehydroepiandrosterone sulfate (DHEAS) ≥40 μg/dL, before age 8 years in girls and 9 years in boys, without breast or testicular enlargement. The aim of this study was to characterize a population of prepubertal Caucasian children with PA and to compare them with regard to gender and body mass index (BMI) (normal BMI vs. overweight/obesity). Methods We performed a cross-sectional study of Portuguese Caucasian prepubertal children followed, due to PA, in pediatric endocrinology clinics of a university hospital. Results Eighty-two girls and 15 boys were included (mean age at evaluation: 7.4 ± 1.3 years). The mean birth weight was 2990 ± 689 g; only two children were small for gestational age. Girls presented premature pubarche at a younger age (median [interquartile range (IQR)] 6 (5-6) years vs. 7 (7-8) years in boys; p < 0.001). No gender differences were found for gestational age, birth weight, maternal age at menarche, anthropometry, bone age advancement or androgen levels. The majority of the subjects were overweight or obese (59%). Overweight/obese PA children were taller and had a more advanced bone age than normal-BMI PA children. Overweight/obese children presented higher levels of DHEAS and androstenedione. Bone age advancement and DHEAS were correlated (r = 0.449; p = 0.05). Conclusions We found no evidence of reduced fetal growth. Girls presented premature pubarche at a younger age. No major gender differences in androgen levels were found in prepuberty. Obese and overweight PA children tend to be taller, have a more advanced bone age and higher levels of androgens than normal-BMI PA children. SN - 2191-0251 UR - https://www.unboundmedicine.com/medline/citation/31472065/Clinical,_biochemical_and_gender_characteristics_of_97_prepubertal_children_with_premature_adrenarche L2 - https://www.degruyter.com/doi/10.1515/jpem-2019-0185 DB - PRIME DP - Unbound Medicine ER -