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Shifts in the skin microbiome associated with diaper dermatitis and emollient treatment amongst infants and toddlers in China.
Exp Dermatol. 2019 11; 28(11):1289-1297.ED

Abstract

BACKGROUND

The microbiological basis of diaper dermatitis has not been clearly elucidated; however, a better understanding of microbial colonization may be vital for developing appropriate therapies.

METHODS

Using 16S-rRNA gene sequencing technology, we characterized and compared the bacterial communities obtained from the buttock skin sites of children with diaper dermatitis and from healthy controls. Bacterial diversity in the buttock lesion area and subsequent recovery after emollient treatment have been discussed herein.

RESULTS

In buttock skin of children with or without diaper dermatitis, Staphylococcus and Anaerococcus were predominant in the total skin microbiome. Compared with the healthy group, the overall skin bacterial richness and diversity were higher in children with diaper dermatitis, with the abundance of Proteobacteria being significantly higher. In the diaper dermatitis group, the richness of Enterococcus, Erwinia and Pseudomonas was significantly higher, and the levels of Clostridium and Actinomyces were significantly lower than those in healthy children. Richness of Staphylococcus aureus was significantly higher in the diaper dermatitis group, whereas that of Staphylococcus epidermidis and Bifidobacterium longum was lower. Staphylococcus epidermidis and Staphylococcus haemolyticus, the dominant species found in buttock skin, were observed to recover earlier after the disease had improved through emollient treatment.

CONCLUSION

Staphylococcus epidermidis, as skin probiotic bacterium, and B longum, Clostridium butyricum and Lactobacillus ruminis, which are intestinal probiotic bacteria, are significantly decreased in diaper dermatitis lesions. These changes in the buttock skin microflora indicate an imbalance in the microflora and suggest that the intestinal microflora may be undergoing dynamic changes. The results of this study suggest that probiotic bacterial supplementation may be useful in the treatment and prevention of diaper dermatitis.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Zheng Y
Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.
Wang Q
Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.
Ma L
Shanghai Jahwa Corporation, Shanghai, China.
Chen Y
Shanghai Jahwa Corporation, Shanghai, China.
Gao Y
Capital Institute of Pediatrics, Beijing, China.
Zhang G
Capital Institute of Pediatrics, Beijing, China.
Cui S
Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.
Liang H
Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.
Song L
Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.
He C
Beijing Key Lab of Plant Resources Research and Development, Beijing Technology and Business University, Beijing, China.

MeSH

Case-Control StudiesChild, PreschoolChinaDiaper RashHumansInfantMicrobiotaSkinSkin Cream

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31472099

Clinical Trial Links

Effect Of Using Oxygen On The Diaper Dermatitis In Infants

Citation

Zheng, Yumei, et al. "Shifts in the Skin Microbiome Associated With Diaper Dermatitis and Emollient Treatment Amongst Infants and Toddlers in China." Experimental Dermatology, vol. 28, no. 11, 2019, pp. 1289-1297.
Zheng Y, Wang Q, Ma L, et al. Shifts in the skin microbiome associated with diaper dermatitis and emollient treatment amongst infants and toddlers in China. Exp Dermatol. 2019;28(11):1289-1297.
Zheng, Y., Wang, Q., Ma, L., Chen, Y., Gao, Y., Zhang, G., Cui, S., Liang, H., Song, L., & He, C. (2019). Shifts in the skin microbiome associated with diaper dermatitis and emollient treatment amongst infants and toddlers in China. Experimental Dermatology, 28(11), 1289-1297. https://doi.org/10.1111/exd.14028
Zheng Y, et al. Shifts in the Skin Microbiome Associated With Diaper Dermatitis and Emollient Treatment Amongst Infants and Toddlers in China. Exp Dermatol. 2019;28(11):1289-1297. PubMed PMID: 31472099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shifts in the skin microbiome associated with diaper dermatitis and emollient treatment amongst infants and toddlers in China. AU - Zheng,Yumei, AU - Wang,Qian, AU - Ma,Laiji, AU - Chen,Yuanyuan, AU - Gao,Ying, AU - Zhang,Gaolei, AU - Cui,Shumei, AU - Liang,Haiyun, AU - Song,Liya, AU - He,Congfen, Y1 - 2019/09/16/ PY - 2018/12/19/received PY - 2019/07/12/revised PY - 2019/08/25/accepted PY - 2019/9/1/pubmed PY - 2020/10/28/medline PY - 2019/9/1/entrez KW - bacterial diversity KW - diaper dermatitis KW - emollient KW - high-throughput sequencing SP - 1289 EP - 1297 JF - Experimental dermatology JO - Exp Dermatol VL - 28 IS - 11 N2 - BACKGROUND: The microbiological basis of diaper dermatitis has not been clearly elucidated; however, a better understanding of microbial colonization may be vital for developing appropriate therapies. METHODS: Using 16S-rRNA gene sequencing technology, we characterized and compared the bacterial communities obtained from the buttock skin sites of children with diaper dermatitis and from healthy controls. Bacterial diversity in the buttock lesion area and subsequent recovery after emollient treatment have been discussed herein. RESULTS: In buttock skin of children with or without diaper dermatitis, Staphylococcus and Anaerococcus were predominant in the total skin microbiome. Compared with the healthy group, the overall skin bacterial richness and diversity were higher in children with diaper dermatitis, with the abundance of Proteobacteria being significantly higher. In the diaper dermatitis group, the richness of Enterococcus, Erwinia and Pseudomonas was significantly higher, and the levels of Clostridium and Actinomyces were significantly lower than those in healthy children. Richness of Staphylococcus aureus was significantly higher in the diaper dermatitis group, whereas that of Staphylococcus epidermidis and Bifidobacterium longum was lower. Staphylococcus epidermidis and Staphylococcus haemolyticus, the dominant species found in buttock skin, were observed to recover earlier after the disease had improved through emollient treatment. CONCLUSION: Staphylococcus epidermidis, as skin probiotic bacterium, and B longum, Clostridium butyricum and Lactobacillus ruminis, which are intestinal probiotic bacteria, are significantly decreased in diaper dermatitis lesions. These changes in the buttock skin microflora indicate an imbalance in the microflora and suggest that the intestinal microflora may be undergoing dynamic changes. The results of this study suggest that probiotic bacterial supplementation may be useful in the treatment and prevention of diaper dermatitis. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/31472099/Shifts_in_the_skin_microbiome_associated_with_diaper_dermatitis_and_emollient_treatment_amongst_infants_and_toddlers_in_China_ DB - PRIME DP - Unbound Medicine ER -