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Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution.
Int J Pharm. 2019 Oct 30; 570:118649.IJ

Abstract

In this study, the impact of binder distribution on the tabletability and compactibility of granules produced by twin-screw melt granulation was investigated. To this end, two grades of dicalcium phosphate anhydrous (fine and coarse) were used as model substances (filler) in combination with two grades of poloxamer (fine and coarse) as melt binder at three concentrations. For the fine filler, granule forming followed the immersion mechanism, whereas a distribution mechanism was observed in case of the coarse filler. Compared to the granules prepared with the coarse filler, the tabletability of granules prepared with the fine filler increased more pronouncedly compared to the corresponding physical mixtures (PM). In general, tabletability, compressibility and compactibility depended predominantly on the distribution of the binder in the tablet, and the homogeneity of distribution correlated with increased tensile strength. Binder distribution was analysed using scanning electron microscopy combined with energy-dispersive X-ray analysis (SEM/EDX) and quantified by image-analysis of the tablet surface. PMs in general varied in tabletability. However, even at tabletability similar to the granules, all PMs suffered from poor flow and/or segregation.

Authors+Show Affiliations

Department of Pharmaceutics, University of Bonn, Germany.Department of Pharmaceutics, University of Bonn, Germany. Electronic address: karl.wagner@uni-bonn.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31472217

Citation

Steffens, Kristina E., and Karl G. Wagner. "Improvement of Tabletability Via Twin-screw Melt Granulation: Focus On Binder Distribution." International Journal of Pharmaceutics, vol. 570, 2019, p. 118649.
Steffens KE, Wagner KG. Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution. Int J Pharm. 2019;570:118649.
Steffens, K. E., & Wagner, K. G. (2019). Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution. International Journal of Pharmaceutics, 570, 118649. https://doi.org/10.1016/j.ijpharm.2019.118649
Steffens KE, Wagner KG. Improvement of Tabletability Via Twin-screw Melt Granulation: Focus On Binder Distribution. Int J Pharm. 2019 Oct 30;570:118649. PubMed PMID: 31472217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution. AU - Steffens,Kristina E, AU - Wagner,Karl G, Y1 - 2019/08/28/ PY - 2019/06/04/received PY - 2019/08/26/revised PY - 2019/08/26/accepted PY - 2019/9/1/pubmed PY - 2020/2/13/medline PY - 2019/9/1/entrez KW - Binder distribution KW - Compactibility KW - Energy dispersive X-ray analysis KW - Tabletability KW - Twin-screw extruder KW - Twin-screw melt granulation SP - 118649 EP - 118649 JF - International journal of pharmaceutics JO - Int J Pharm VL - 570 N2 - In this study, the impact of binder distribution on the tabletability and compactibility of granules produced by twin-screw melt granulation was investigated. To this end, two grades of dicalcium phosphate anhydrous (fine and coarse) were used as model substances (filler) in combination with two grades of poloxamer (fine and coarse) as melt binder at three concentrations. For the fine filler, granule forming followed the immersion mechanism, whereas a distribution mechanism was observed in case of the coarse filler. Compared to the granules prepared with the coarse filler, the tabletability of granules prepared with the fine filler increased more pronouncedly compared to the corresponding physical mixtures (PM). In general, tabletability, compressibility and compactibility depended predominantly on the distribution of the binder in the tablet, and the homogeneity of distribution correlated with increased tensile strength. Binder distribution was analysed using scanning electron microscopy combined with energy-dispersive X-ray analysis (SEM/EDX) and quantified by image-analysis of the tablet surface. PMs in general varied in tabletability. However, even at tabletability similar to the granules, all PMs suffered from poor flow and/or segregation. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/31472217/Improvement_of_tabletability_via_twin_screw_melt_granulation:_Focus_on_binder_distribution_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(19)30694-5 DB - PRIME DP - Unbound Medicine ER -