Tags

Type your tag names separated by a space and hit enter

Carrageenan-based functional hydrogel film reinforced with sulfur nanoparticles and grapefruit seed extract for wound healing application.
Carbohydr Polym. 2019 Nov 15; 224:115191.CP

Abstract

κ-Carrageenan-based (Carr) functional wound healing hydrogel films were prepared by incorporating chitosan capped sulfur nanoparticles (SNP) and grapefruit seed extract (GSE). In vivo wound healing effect of the hydrogel films was tested using artificially wounded male Sprague-Dawley rats. The hydrogel film (Carr/GSE/SNP) showed higher mechanical strength, swelling ratio and ultraviolet barrier properties than the carrageenan film, but the water vapor permeability and water solubility were decreased. The hydrogel film showed antibacterial activity strong enough to destroy Staphylococcus epidermis and Escherichia coli within 3 h of incubation and showed high biocompatibility against mouse fibroblast (L929 cell lines). The hydrogel film (Carr/GSE/SNP3%) showed excellent wound healing effect (1.3% wound area after 2 weeks) compared to the control group (31% wound area after 2 weeks) through in vivo wound healing test. Histological examination showed the complete appearance of the healed epidermis. The Carr/GSE/SNP hydrogel films are most likely to be used for the treatment of full-thickness wounds.

Authors+Show Affiliations

Department of Food and Nutrition, BioNanocomposite Research Center, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.Department of Food and Nutrition, BioNanocomposite Research Center, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.Department of Food and Nutrition, BioNanocomposite Research Center, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address: jwrhim@khu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31472875

Citation

Jaiswal, Lily, et al. "Carrageenan-based Functional Hydrogel Film Reinforced With Sulfur Nanoparticles and Grapefruit Seed Extract for Wound Healing Application." Carbohydrate Polymers, vol. 224, 2019, p. 115191.
Jaiswal L, Shankar S, Rhim JW. Carrageenan-based functional hydrogel film reinforced with sulfur nanoparticles and grapefruit seed extract for wound healing application. Carbohydr Polym. 2019;224:115191.
Jaiswal, L., Shankar, S., & Rhim, J. W. (2019). Carrageenan-based functional hydrogel film reinforced with sulfur nanoparticles and grapefruit seed extract for wound healing application. Carbohydrate Polymers, 224, 115191. https://doi.org/10.1016/j.carbpol.2019.115191
Jaiswal L, Shankar S, Rhim JW. Carrageenan-based Functional Hydrogel Film Reinforced With Sulfur Nanoparticles and Grapefruit Seed Extract for Wound Healing Application. Carbohydr Polym. 2019 Nov 15;224:115191. PubMed PMID: 31472875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carrageenan-based functional hydrogel film reinforced with sulfur nanoparticles and grapefruit seed extract for wound healing application. AU - Jaiswal,Lily, AU - Shankar,Shiv, AU - Rhim,Jong-Whan, Y1 - 2019/08/12/ PY - 2019/07/17/received PY - 2019/07/31/revised PY - 2019/08/09/accepted PY - 2019/9/2/entrez PY - 2019/9/2/pubmed PY - 2020/2/6/medline KW - Antibacterial activity KW - Grapefruit seed extract KW - Hydrogel film KW - Sulfur nanoparticles KW - Wound healing KW - κ-Carrageenan SP - 115191 EP - 115191 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 224 N2 - κ-Carrageenan-based (Carr) functional wound healing hydrogel films were prepared by incorporating chitosan capped sulfur nanoparticles (SNP) and grapefruit seed extract (GSE). In vivo wound healing effect of the hydrogel films was tested using artificially wounded male Sprague-Dawley rats. The hydrogel film (Carr/GSE/SNP) showed higher mechanical strength, swelling ratio and ultraviolet barrier properties than the carrageenan film, but the water vapor permeability and water solubility were decreased. The hydrogel film showed antibacterial activity strong enough to destroy Staphylococcus epidermis and Escherichia coli within 3 h of incubation and showed high biocompatibility against mouse fibroblast (L929 cell lines). The hydrogel film (Carr/GSE/SNP3%) showed excellent wound healing effect (1.3% wound area after 2 weeks) compared to the control group (31% wound area after 2 weeks) through in vivo wound healing test. Histological examination showed the complete appearance of the healed epidermis. The Carr/GSE/SNP hydrogel films are most likely to be used for the treatment of full-thickness wounds. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/31472875/Carrageenan_based_functional_hydrogel_film_reinforced_with_sulfur_nanoparticles_and_grapefruit_seed_extract_for_wound_healing_application_ DB - PRIME DP - Unbound Medicine ER -