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Diagnostic performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at estimating glomerular filtration rate in adults with diabetes mellitus: a systematic review and meta-analysis protocol.
BMJ Open. 2019 Aug 30; 9(8):e031558.BO

Abstract

INTRODUCTION

Timely detection leading to the implementation of reno-protective measures reduces the progression of diabetic kidney disease. Estimated glomerular filtration rate (eGFR) is a major surrogate of kidney function. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equation is a tool to estimate GFR. This protocol outlines a systematic-review, assessing the diagnostic accuracy of the CKD-EPI equation in adults with diabetes.

METHODS AND ANALYSIS

MEDLINE, Embase, Cochrane Central Register of Controlled Trials and grey literature will be searched for publications in English, Farsi, Dutch and Chinese from 2009 (when CKD-EPI was first introduced) to January 2019. Bridging searches will be conducted to capture literature published from January 2019 until final review publication. The inclusion criteria will be (1) study participants with diabetes; (2) age ≥18 years; (3) creatinine-based CKD-EPI eGFR as index test; (4) measured GFR using the clearance/plasma disappearance of inulin, iohexol, iothalamate, diethylenetriamine-pentaacetic acid (DTPA) or chromium labelled ethylenediaminetetraacetic acid (Cr-EDTA) as reference test; (5) report of the diagnostic accuracy of the index test. Exclusion criteria will be participants with renal transplant, chronic use of corticosteroids, chronic inflammatory diseases, pregnancy, non-diabetes related kidney disease, thalassaemia, heart failure, pregnancy and potential kidney donors as well as critically ill patients. Screening, eligibility check, risk of bias assessment and data extraction will be carried out by two independent reviewers. Any discrepancies will be discussed, and third-party opinion will be sought. The risk of bias will be assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A quantitative synthesis of the aggregated-data will be used if the included studies are homogenous.

ETHICS AND DISSEMINATION

No ethics approval is required. The outcome will be published in a peer-reviewed journal. The results will help researchers and clinicians evaluate the diagnostic accuracy of the creatinine-based CKD-EPI eGFR in adults with diabetes.

PROSPERO REGISTRATION NUMBER

CRD42018108776.

Links

PMC Free PDF

Authors+Show Affiliations

Zafari N
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia zafarin@student.unimelb.edu.au.
Churilov L
Florey Institute of Neuroscience and Mental Health, Heidelberg,Melbourne, Victoria, Australia.
MacIsaac RJ
Department of Endocrinology & Diabetes, St Vincent's Hospital, The University of Melbourne, Fitzroy, Melbourne, Victoria, Australia.
Torkamani N
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.
Baxter H
Austin Health Sciences Library, Austin Health, Heidelberg, Victoria, Australia.
Kiburg KV
Department of Endocrinology & Diabetes, St Vincent's Hospital, The University of Melbourne, Fitzroy, Melbourne, Victoria, Australia.
Ekinci E
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.

MeSH

AdultBiomarkersComorbidityCreatinineCystatin CDiabetes MellitusGlomerular Filtration RateHumansKidneyMeta-Analysis as TopicRenal Insufficiency, ChronicResearch DesignSystematic Reviews as Topic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31473625

Citation

Zafari, Neda, et al. "Diagnostic Performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equation at Estimating Glomerular Filtration Rate in Adults With Diabetes Mellitus: a Systematic Review and Meta-analysis Protocol." BMJ Open, vol. 9, no. 8, 2019, pp. e031558.
Zafari N, Churilov L, MacIsaac RJ, et al. Diagnostic performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at estimating glomerular filtration rate in adults with diabetes mellitus: a systematic review and meta-analysis protocol. BMJ Open. 2019;9(8):e031558.
Zafari, N., Churilov, L., MacIsaac, R. J., Torkamani, N., Baxter, H., Kiburg, K. V., & Ekinci, E. (2019). Diagnostic performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at estimating glomerular filtration rate in adults with diabetes mellitus: a systematic review and meta-analysis protocol. BMJ Open, 9(8), e031558. https://doi.org/10.1136/bmjopen-2019-031558
Zafari N, et al. Diagnostic Performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equation at Estimating Glomerular Filtration Rate in Adults With Diabetes Mellitus: a Systematic Review and Meta-analysis Protocol. BMJ Open. 2019 Aug 30;9(8):e031558. PubMed PMID: 31473625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at estimating glomerular filtration rate in adults with diabetes mellitus: a systematic review and meta-analysis protocol. AU - Zafari,Neda, AU - Churilov,Leonid, AU - MacIsaac,Richard J, AU - Torkamani,Niloufar, AU - Baxter,Helen, AU - Kiburg,Katerina V, AU - Ekinci,Elif, Y1 - 2019/08/30/ PY - 2019/9/2/entrez PY - 2019/9/2/pubmed PY - 2020/9/15/medline KW - CKD-EPI KW - Diabetes mellitus KW - diabetic kidney disease KW - eGFR KW - glomerular filtration rate SP - e031558 EP - e031558 JF - BMJ open JO - BMJ Open VL - 9 IS - 8 N2 - INTRODUCTION: Timely detection leading to the implementation of reno-protective measures reduces the progression of diabetic kidney disease. Estimated glomerular filtration rate (eGFR) is a major surrogate of kidney function. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equation is a tool to estimate GFR. This protocol outlines a systematic-review, assessing the diagnostic accuracy of the CKD-EPI equation in adults with diabetes. METHODS AND ANALYSIS: MEDLINE, Embase, Cochrane Central Register of Controlled Trials and grey literature will be searched for publications in English, Farsi, Dutch and Chinese from 2009 (when CKD-EPI was first introduced) to January 2019. Bridging searches will be conducted to capture literature published from January 2019 until final review publication. The inclusion criteria will be (1) study participants with diabetes; (2) age ≥18 years; (3) creatinine-based CKD-EPI eGFR as index test; (4) measured GFR using the clearance/plasma disappearance of inulin, iohexol, iothalamate, diethylenetriamine-pentaacetic acid (DTPA) or chromium labelled ethylenediaminetetraacetic acid (Cr-EDTA) as reference test; (5) report of the diagnostic accuracy of the index test. Exclusion criteria will be participants with renal transplant, chronic use of corticosteroids, chronic inflammatory diseases, pregnancy, non-diabetes related kidney disease, thalassaemia, heart failure, pregnancy and potential kidney donors as well as critically ill patients. Screening, eligibility check, risk of bias assessment and data extraction will be carried out by two independent reviewers. Any discrepancies will be discussed, and third-party opinion will be sought. The risk of bias will be assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A quantitative synthesis of the aggregated-data will be used if the included studies are homogenous. ETHICS AND DISSEMINATION: No ethics approval is required. The outcome will be published in a peer-reviewed journal. The results will help researchers and clinicians evaluate the diagnostic accuracy of the creatinine-based CKD-EPI eGFR in adults with diabetes. PROSPERO REGISTRATION NUMBER: CRD42018108776. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/31473625/Diagnostic_performance_of_the_Chronic_Kidney_Disease_Epidemiology_Collaboration__CKD_EPI__equation_at_estimating_glomerular_filtration_rate_in_adults_with_diabetes_mellitus:_a_systematic_review_and_meta_analysis_protocol_ DB - PRIME DP - Unbound Medicine ER -