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The CNS Immune Landscape from the Viewpoint of a T Cell.
Trends Neurosci 2019; 42(10):667-679TN

Abstract

Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During immune surveillance, T cells can patrol the CNS-associated border regions to sense pathogenic alterations. While access to the CNS parenchyma is restricted in the steady state, various disease processes can initiate parenchymal T cell CNS invasion. However, to breach the glia limitans, T cells must become reactivated within the meningeal spaces. T cells cannot sense native antigens (Ags), but instead recognize small processed peptides bound to MHC molecules and presented on the surface of Ag-presenting cells (APCs). In this review, we focus on (CD4+) T cell-CNS interactions that are dependent on Ag recognition. We discuss the potential paths and mechanisms of T cell entry into the CNS, in particular with respect to CNS-resident APCs, which present CNS-derived Ag in the absence of inflammation.

Authors+Show Affiliations

Experimental Immunology, University of Zurich, Zurich, Switzerland.Experimental Immunology, University of Zurich, Zurich, Switzerland.Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, Göttingen, Germany.Experimental Immunology, University of Zurich, Zurich, Switzerland. Electronic address: becher@immunology.uzh.ch.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31474310

Citation

Mundt, Sarah, et al. "The CNS Immune Landscape From the Viewpoint of a T Cell." Trends in Neurosciences, vol. 42, no. 10, 2019, pp. 667-679.
Mundt S, Greter M, Flügel A, et al. The CNS Immune Landscape from the Viewpoint of a T Cell. Trends Neurosci. 2019;42(10):667-679.
Mundt, S., Greter, M., Flügel, A., & Becher, B. (2019). The CNS Immune Landscape from the Viewpoint of a T Cell. Trends in Neurosciences, 42(10), pp. 667-679. doi:10.1016/j.tins.2019.07.008.
Mundt S, et al. The CNS Immune Landscape From the Viewpoint of a T Cell. Trends Neurosci. 2019;42(10):667-679. PubMed PMID: 31474310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CNS Immune Landscape from the Viewpoint of a T Cell. AU - Mundt,Sarah, AU - Greter,Melanie, AU - Flügel,Alexander, AU - Becher,Burkhard, Y1 - 2019/08/29/ PY - 2019/04/26/received PY - 2019/07/25/revised PY - 2019/07/26/accepted PY - 2019/9/3/pubmed PY - 2019/9/3/medline PY - 2019/9/3/entrez KW - B cells KW - CNS leukocytes KW - T cells KW - antigen presentation KW - blood–brain barrier KW - border-associated macrophages KW - central nervous system KW - dendritic cells KW - immunopathology KW - inflammation KW - microglia KW - monocytes KW - neuroimmunology KW - phagocytes SP - 667 EP - 679 JF - Trends in neurosciences JO - Trends Neurosci. VL - 42 IS - 10 N2 - Neuro-immune interactions are not only vital for the control of neurotropic pathogens, but also appear to influence brain development and homeostasis. During immune surveillance, T cells can patrol the CNS-associated border regions to sense pathogenic alterations. While access to the CNS parenchyma is restricted in the steady state, various disease processes can initiate parenchymal T cell CNS invasion. However, to breach the glia limitans, T cells must become reactivated within the meningeal spaces. T cells cannot sense native antigens (Ags), but instead recognize small processed peptides bound to MHC molecules and presented on the surface of Ag-presenting cells (APCs). In this review, we focus on (CD4+) T cell-CNS interactions that are dependent on Ag recognition. We discuss the potential paths and mechanisms of T cell entry into the CNS, in particular with respect to CNS-resident APCs, which present CNS-derived Ag in the absence of inflammation. SN - 1878-108X UR - https://www.unboundmedicine.com/medline/citation/31474310/The_CNS_Immune_Landscape_from_the_Viewpoint_of_a_T_Cell L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-2236(19)30131-6 DB - PRIME DP - Unbound Medicine ER -