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Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi.
C R Biol. 2019 Jun - Aug; 342(5-6):192-198.CR

Abstract

Exposure to lead is a threat factor for neurodegenerative disorders progress as it could trigger dopaminergic deficiency. We aimed herein to assess the effect of acute lead exposure (25mg/kg B.W i.p.) during three continuous days on the dopaminergic and noradrenergic systems together with locomotor performance in Meriones shawi (M. shawi), then the neuroprotective potential of curcumin-III (30mg/kg B.W) by oral gavage. Pb-exposed M. shawi exhibited increased tyrosine hydroxylase (TH) immunoreactivity in substantia nigra compacta (SNc), ventral tegmental area (VTA), locus coeruleus (LC), and dorsal striatum (DS), unlike the controls. This was correlated with decreased locomotor performance. A noticeable protective effect by co-treatment with curcumin-III was observed; in consequence, TH-immunoreactivity and locomotor disturbance were restored in Pb-treated Meriones. Our data results proved, on the one hand, an evident neurotoxic effect of acute Pb exposure and, on the other hand, a potent therapeutic effect of curcumin-III. Thereby, this compound may be recommended as a neuroprotective molecule for neurodegenerative disorders involving catecholaminergic impairment initiated by metallic elements.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tamegart L
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Avenue My Abdellah, B.P. 2390, Marrakech, Morocco.
Abbaoui A
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Avenue My Abdellah, B.P. 2390, Marrakech, Morocco.
El Khiat A
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Avenue My Abdellah, B.P. 2390, Marrakech, Morocco.
Bouyatas MM
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Avenue My Abdellah, B.P. 2390, Marrakech, Morocco; Cadi Ayyad University, Multidisciplinary Faculty of Safi, Department of Biology, Safi, Morocco.
Gamrani H
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Avenue My Abdellah, B.P. 2390, Marrakech, Morocco. Electronic address: gamrani@uca.ac.ma.

MeSH

Administration, OralAnimalsCorpus StriatumCurcuminDopaminergic NeuronsGerbillinaeLead Poisoning, Nervous SystemLocus CoeruleusMaleMovement DisordersNeuroprotective AgentsParasympathetic Nervous SystemSubstantia NigraVentral Tegmental Area

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31474522

Citation

Tamegart, Lahcen, et al. "Altered Nigrostriatal Dopaminergic and Noradrenergic System Prompted By Systemic Lead Toxicity Versus a Treatment By curcumin-III in the Desert Rodent Meriones Shawi." Comptes Rendus Biologies, vol. 342, no. 5-6, 2019, pp. 192-198.
Tamegart L, Abbaoui A, El Khiat A, et al. Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi. C R Biol. 2019;342(5-6):192-198.
Tamegart, L., Abbaoui, A., El Khiat, A., Bouyatas, M. M., & Gamrani, H. (2019). Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi. Comptes Rendus Biologies, 342(5-6), 192-198. https://doi.org/10.1016/j.crvi.2019.07.004
Tamegart L, et al. Altered Nigrostriatal Dopaminergic and Noradrenergic System Prompted By Systemic Lead Toxicity Versus a Treatment By curcumin-III in the Desert Rodent Meriones Shawi. C R Biol. 2019 Jun - Aug;342(5-6):192-198. PubMed PMID: 31474522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered nigrostriatal dopaminergic and noradrenergic system prompted by systemic lead toxicity versus a treatment by curcumin-III in the desert rodent Meriones shawi. AU - Tamegart,Lahcen, AU - Abbaoui,Abdellatif, AU - El Khiat,Abdelaati, AU - Bouyatas,Moulay Mustapha, AU - Gamrani,Halima, Y1 - 2019/08/29/ PY - 2019/06/13/received PY - 2019/07/15/revised PY - 2019/07/16/accepted PY - 2019/9/3/pubmed PY - 2019/12/24/medline PY - 2019/9/3/entrez KW - Curcumin-III KW - Dopamine and noradrenaline KW - Lead neurotoxicity KW - Locomotion KW - Meriones shawi KW - Midbrain SP - 192 EP - 198 JF - Comptes rendus biologies JO - C R Biol VL - 342 IS - 5-6 N2 - Exposure to lead is a threat factor for neurodegenerative disorders progress as it could trigger dopaminergic deficiency. We aimed herein to assess the effect of acute lead exposure (25mg/kg B.W i.p.) during three continuous days on the dopaminergic and noradrenergic systems together with locomotor performance in Meriones shawi (M. shawi), then the neuroprotective potential of curcumin-III (30mg/kg B.W) by oral gavage. Pb-exposed M. shawi exhibited increased tyrosine hydroxylase (TH) immunoreactivity in substantia nigra compacta (SNc), ventral tegmental area (VTA), locus coeruleus (LC), and dorsal striatum (DS), unlike the controls. This was correlated with decreased locomotor performance. A noticeable protective effect by co-treatment with curcumin-III was observed; in consequence, TH-immunoreactivity and locomotor disturbance were restored in Pb-treated Meriones. Our data results proved, on the one hand, an evident neurotoxic effect of acute Pb exposure and, on the other hand, a potent therapeutic effect of curcumin-III. Thereby, this compound may be recommended as a neuroprotective molecule for neurodegenerative disorders involving catecholaminergic impairment initiated by metallic elements. SN - 1768-3238 UR - https://www.unboundmedicine.com/medline/citation/31474522/Altered_nigrostriatal_dopaminergic_and_noradrenergic_system_prompted_by_systemic_lead_toxicity_versus_a_treatment_by_curcumin_III_in_the_desert_rodent_Meriones_shawi_ DB - PRIME DP - Unbound Medicine ER -

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