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First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis.
BMC Cancer. 2019 Sep 02; 19(1):871.BC

Abstract

BACKGROUND

The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association between first-degree family history of female breast cancer and prostate cancer risk.

METHODS

Databases, including MEDLINE, Embase, and Web of Science, were searched for all associated studies that evaluated associations between first-degree family history of female breast cancer and prostate cancer risk up to December 31, 2018. Information on study characteristics and outcomes were extracted based on the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. The quality of evidence was assessed using the GRADE approach.

RESULTS

Eighteen studies involving 17,004,892 individuals were included in the meta-analysis. Compared with no family history of female breast cancer, history of female breast cancer in first-degree relatives was associated with an increased risk of prostate cancer [relative risk (RR) 1.18, 95% confidence interval (CI) 1.12-1.25] with moderate-quality evidence. A history of breast cancer in mothers only (RR 1.19, 95% CI 1.10-1.28) and sisters only (RR 1.71, 95% CI 1.43-2.04) was associated with increased prostate cancer risk with moderate-quality evidence. However, a family history of breast cancer in daughters only was not associated with prostate cancer incidence (RR 1.74, 95% CI 0.74-4.12) with moderate-quality evidence. A family history of female breast cancer in first-degree relatives was associated with an 18% increased risk of lethal prostate cancer (95% CI 1.04-1.34) with low-quality evidence.

CONCLUSIONS

This review demonstrates that men with a family history of female breast cancer in first-degree relatives had an increased risk of prostate cancer, including risk of lethal prostate cancer. These findings may guide screening, earlier detection, and treatment of men with a family history of female breast cancer in first-degree relatives.

Authors+Show Affiliations

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu, 610041, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu, 610041, China. State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, China.Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu, 610041, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu, 610041, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu, 610041, China.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37, Guo Xue Road, Chengdu, 610041, China. dong_qiang@mcwcums.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

31477094

Citation

Ren, Zheng-Ju, et al. "First-degree Family History of Breast Cancer Is Associated With Prostate Cancer Risk: a Systematic Review and Meta-analysis." BMC Cancer, vol. 19, no. 1, 2019, p. 871.
Ren ZJ, Cao DH, Zhang Q, et al. First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis. BMC Cancer. 2019;19(1):871.
Ren, Z. J., Cao, D. H., Zhang, Q., Ren, P. W., Liu, L. R., Wei, Q., Wei, W. R., & Dong, Q. (2019). First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis. BMC Cancer, 19(1), 871. https://doi.org/10.1186/s12885-019-6055-9
Ren ZJ, et al. First-degree Family History of Breast Cancer Is Associated With Prostate Cancer Risk: a Systematic Review and Meta-analysis. BMC Cancer. 2019 Sep 2;19(1):871. PubMed PMID: 31477094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis. AU - Ren,Zheng-Ju, AU - Cao,De-Hong, AU - Zhang,Qin, AU - Ren,Peng-Wei, AU - Liu,Liang-Ren, AU - Wei,Qiang, AU - Wei,Wu-Ran, AU - Dong,Qiang, Y1 - 2019/09/02/ PY - 2019/03/27/received PY - 2019/08/19/accepted PY - 2019/9/4/entrez PY - 2019/9/4/pubmed PY - 2020/2/19/medline KW - Breast cancer KW - Family history KW - Meta-analysis KW - Prostate cancer SP - 871 EP - 871 JF - BMC cancer JO - BMC Cancer VL - 19 IS - 1 N2 - BACKGROUND: The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association between first-degree family history of female breast cancer and prostate cancer risk. METHODS: Databases, including MEDLINE, Embase, and Web of Science, were searched for all associated studies that evaluated associations between first-degree family history of female breast cancer and prostate cancer risk up to December 31, 2018. Information on study characteristics and outcomes were extracted based on the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. The quality of evidence was assessed using the GRADE approach. RESULTS: Eighteen studies involving 17,004,892 individuals were included in the meta-analysis. Compared with no family history of female breast cancer, history of female breast cancer in first-degree relatives was associated with an increased risk of prostate cancer [relative risk (RR) 1.18, 95% confidence interval (CI) 1.12-1.25] with moderate-quality evidence. A history of breast cancer in mothers only (RR 1.19, 95% CI 1.10-1.28) and sisters only (RR 1.71, 95% CI 1.43-2.04) was associated with increased prostate cancer risk with moderate-quality evidence. However, a family history of breast cancer in daughters only was not associated with prostate cancer incidence (RR 1.74, 95% CI 0.74-4.12) with moderate-quality evidence. A family history of female breast cancer in first-degree relatives was associated with an 18% increased risk of lethal prostate cancer (95% CI 1.04-1.34) with low-quality evidence. CONCLUSIONS: This review demonstrates that men with a family history of female breast cancer in first-degree relatives had an increased risk of prostate cancer, including risk of lethal prostate cancer. These findings may guide screening, earlier detection, and treatment of men with a family history of female breast cancer in first-degree relatives. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/31477094/First_degree_family_history_of_breast_cancer_is_associated_with_prostate_cancer_risk:_a_systematic_review_and_meta_analysis_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6055-9 DB - PRIME DP - Unbound Medicine ER -