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A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" infection in Russia.
Ticks Tick Borne Dis 2019; 10(6):101278TT

Abstract

North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was registered. In order to identify the etiology of this infection, blood and brain samples from the patient were examined for the presence of a wide range of tick-transmitted agents and enteric viruses by polymerase chain reaction with subsequent sequencing. Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" DNA was identified in both blood and brain samples. Rickettsia sibirica was characterized by the gltA, ompA and ompB genes, and "Candidatus R. tarasevichiae" was characterized by the gltA and ompB genes. We report the first case of mixed R. sibirica and "Candidatus R. tarasevichiae" human infection with a fatal outcome in Russia.

Authors+Show Affiliations

Omsk Research Institute of Natural Focal Infections, Omsk, Russia; Omsk State Medical University, Omsk, Russia. Electronic address: rickettsia@mail.ru.Omsk Research Institute of Natural Focal Infections, Omsk, Russia. Electronic address: samoilenko.irinasamoylenko@yandex.ru.Omsk Research Institute of Natural Focal Infections, Omsk, Russia; Omsk State Medical University, Omsk, Russia. Electronic address: studi1990@mail.ru.Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: igolkina@inbox.ru.Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: rarv@niboch.nsc.ru.Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: ezhr@niboch.nsc.ru.Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: tkachev@niboch.nsc.ru.The Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Regional Department in Krasnoyarsk Province, Krasnoyarsk, Russia. Electronic address: oen@24.rospotrebnadzor.ru.Center of Hygiene and Epidemiology in Krasnoyarsk Region, Krasnoyarsk, Russia. Electronic address: oiooi_fguz@24.rospotrebnadzor.ru.Kuraginsky District Hospital, Krasnoyarsk region, Kuragino, Russia. Electronic address: pezan@mail.ru.Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: tikunova@niboch.nsc.ru.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31477530

Citation

Rudakov, Nikolay, et al. "A Fatal Case of Tick-borne Rickettsiosis Caused By Mixed Rickettsia Sibirica Subsp. Sibirica and "Candidatus Rickettsia Tarasevichiae" Infection in Russia." Ticks and Tick-borne Diseases, vol. 10, no. 6, 2019, p. 101278.
Rudakov N, Samoylenko I, Shtrek S, et al. A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" infection in Russia. Ticks Tick Borne Dis. 2019;10(6):101278.
Rudakov, N., Samoylenko, I., Shtrek, S., Igolkina, Y., Rar, V., Zhirakovskaia, E., ... Tikunova, N. (2019). A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" infection in Russia. Ticks and Tick-borne Diseases, 10(6), p. 101278. doi:10.1016/j.ttbdis.2019.101278.
Rudakov N, et al. A Fatal Case of Tick-borne Rickettsiosis Caused By Mixed Rickettsia Sibirica Subsp. Sibirica and "Candidatus Rickettsia Tarasevichiae" Infection in Russia. Ticks Tick Borne Dis. 2019;10(6):101278. PubMed PMID: 31477530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" infection in Russia. AU - Rudakov,Nikolay, AU - Samoylenko,Irina, AU - Shtrek,Sergey, AU - Igolkina,Yana, AU - Rar,Vera, AU - Zhirakovskaia,Elena, AU - Tkachev,Sergey, AU - Kostrykina,Tatiana, AU - Blokhina,Inga, AU - Lentz,Petr, AU - Tikunova,Nina, Y1 - 2019/08/24/ PY - 2018/12/06/received PY - 2019/07/08/revised PY - 2019/08/23/accepted PY - 2019/9/4/pubmed PY - 2019/9/4/medline PY - 2019/9/4/entrez KW - Candidatus Rickettsia tarasevichiae KW - Rickettsia sibirica KW - Rickettsiosis SP - 101278 EP - 101278 JF - Ticks and tick-borne diseases JO - Ticks Tick Borne Dis VL - 10 IS - 6 N2 - North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was registered. In order to identify the etiology of this infection, blood and brain samples from the patient were examined for the presence of a wide range of tick-transmitted agents and enteric viruses by polymerase chain reaction with subsequent sequencing. Rickettsia sibirica subsp. sibirica and "Candidatus Rickettsia tarasevichiae" DNA was identified in both blood and brain samples. Rickettsia sibirica was characterized by the gltA, ompA and ompB genes, and "Candidatus R. tarasevichiae" was characterized by the gltA and ompB genes. We report the first case of mixed R. sibirica and "Candidatus R. tarasevichiae" human infection with a fatal outcome in Russia. SN - 1877-9603 UR - https://www.unboundmedicine.com/medline/citation/31477530/A_fatal_case_of_tick-borne_rickettsiosis_caused_by_mixed_Rickettsia_sibirica_subsp._sibirica_and_"Candidatus_Rickettsia_tarasevichiae"_infection_in_Russia L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-959X(18)30495-3 DB - PRIME DP - Unbound Medicine ER -