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Severe Eosinophilic Asthma.
J Clin Med 2019; 8(9)JC

Abstract

Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients' quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects. Eosinophils, although at first considered insignificant, were later specifically associated with features of the ongoing inflammatory process in asthma, particularly in the severe case. In this review, we discuss new insights into the pathogenesis of severe asthma related to eosinophilic inflammation and the pivotal role of cytokines in a spectrum that is usually referred to as "T2-high inflammation" that accounts for almost half of patients with severe asthma. Recent literature is summarized as to the role of eosinophils in asthmatic inflammation, airway remodeling, and airway hypersensitivity. Major advances in the management of severe asthma occurred the past few years due to the new targeted biological therapies. Novel biologics that are already widely used in severe eosinophilic asthma are discussed, focusing on the choice of the right treatment for the right patient. These monoclonal antibodies primarily led to a significant reduction of asthma exacerbations, as well as improvement of lung function and patient quality of life.

Authors+Show Affiliations

Department of Respiratory Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.Department of Respiratory Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.Department of Respiratory Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece. petros44@hotmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31480806

Citation

Bakakos, Agamemnon, et al. "Severe Eosinophilic Asthma." Journal of Clinical Medicine, vol. 8, no. 9, 2019.
Bakakos A, Loukides S, Bakakos P. Severe Eosinophilic Asthma. J Clin Med. 2019;8(9).
Bakakos, A., Loukides, S., & Bakakos, P. (2019). Severe Eosinophilic Asthma. Journal of Clinical Medicine, 8(9), doi:10.3390/jcm8091375.
Bakakos A, Loukides S, Bakakos P. Severe Eosinophilic Asthma. J Clin Med. 2019 Sep 2;8(9) PubMed PMID: 31480806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe Eosinophilic Asthma. AU - Bakakos,Agamemnon, AU - Loukides,Stelios, AU - Bakakos,Petros, Y1 - 2019/09/02/ PY - 2019/07/25/received PY - 2019/08/28/revised PY - 2019/08/29/accepted PY - 2019/9/5/entrez KW - anti-IL-5 KW - eosinophil KW - inflammation KW - interleukin-4 KW - interleukin-5 (IL-5) KW - severe asthma JF - Journal of clinical medicine JO - J Clin Med VL - 8 IS - 9 N2 - Asthma is a heterogeneous disease with varying severity. Severe asthma is a subject of constant research because it greatly affects patients' quality of life, and patients with severe asthma experience symptoms, exacerbations, and medication side effects. Eosinophils, although at first considered insignificant, were later specifically associated with features of the ongoing inflammatory process in asthma, particularly in the severe case. In this review, we discuss new insights into the pathogenesis of severe asthma related to eosinophilic inflammation and the pivotal role of cytokines in a spectrum that is usually referred to as "T2-high inflammation" that accounts for almost half of patients with severe asthma. Recent literature is summarized as to the role of eosinophils in asthmatic inflammation, airway remodeling, and airway hypersensitivity. Major advances in the management of severe asthma occurred the past few years due to the new targeted biological therapies. Novel biologics that are already widely used in severe eosinophilic asthma are discussed, focusing on the choice of the right treatment for the right patient. These monoclonal antibodies primarily led to a significant reduction of asthma exacerbations, as well as improvement of lung function and patient quality of life. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/31480806/Severe_Eosinophilic_Asthma DB - PRIME DP - Unbound Medicine ER -
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