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Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients with Colorectal Malignancy: Comparison of Agreement Between Methods.
Nutr Cancer. 2020; 72(6):1074-1083.NC

Abstract

Background:

Low skeletal muscle index (SMI) and sarcopenia adversely affect clinical outcomes in oncology patients. Study aims were to assess the agreement of bioelectrical impedance analysis (BIA), mid-arm muscle circumference (MAMC), and computed tomography (CT) at the third lumbar vertebra (L3), for the measurement of muscle mass and identification of sarcopenia, in patients with colorectal cancer (CRC).Method: A comparison study of low SMI and sarcopenia determined by BIA and MAMC, compared to CT. Sensitivity, specificity and area under the curve (AUC) were calculated.

Results:

CT scans were obtained for 100 participants. Low SMI was identified in 29%, 57%, and 20% of participants using CT at L3, BIA, and MAMC, respectively. For low muscle mass BIA showed 60% of participants were correctly classified (AUC 0.619, sensitivity 80%, specificity 52%, kappa 0.241, P = 0.009) and for MAMC, 73% of participants were correctly classified (AUC 0.625, sensitivity 38%, specificity 88%, kappa 0.286, P = 0.005). There were 14%, 31%, and 10% of participants identified as having sarcopenia from CT, BIA, and MAMC, respectively.

Conclusions:

Both BIA and MAMC show a poor level of agreement for measuring muscle mass compared to CT scans using L3 in patients with CRC.

Authors+Show Affiliations

School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, Manchester, UK.School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, Manchester, UK. Intestinal Failure Unit, Ward H8, Salford Royal NHS Foundation Trust, Salford, UK.School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, Manchester, UK. Intestinal Failure Unit, Ward H8, Salford Royal NHS Foundation Trust, Salford, UK. School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, Manchester, UK. Manchester University NHS Foundation Trust, Manchester, UK.Behaviour & Health Research Unit & Cambridge Research Methods Hub, University of Cambridge, Cambridge, UK.School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, Manchester, UK. Intestinal Failure Unit, Ward H8, Salford Royal NHS Foundation Trust, Salford, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31482717

Citation

Jones, Debra J., et al. "Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients With Colorectal Malignancy: Comparison of Agreement Between Methods." Nutrition and Cancer, vol. 72, no. 6, 2020, pp. 1074-1083.
Jones DJ, Lal S, Strauss BJ, et al. Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients with Colorectal Malignancy: Comparison of Agreement Between Methods. Nutr Cancer. 2020;72(6):1074-1083.
Jones, D. J., Lal, S., Strauss, B. J., Todd, C., Pilling, M., & Burden, S. T. (2020). Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients with Colorectal Malignancy: Comparison of Agreement Between Methods. Nutrition and Cancer, 72(6), 1074-1083. https://doi.org/10.1080/01635581.2019.1659381
Jones DJ, et al. Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients With Colorectal Malignancy: Comparison of Agreement Between Methods. Nutr Cancer. 2020;72(6):1074-1083. PubMed PMID: 31482717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of Muscle Mass and Sarcopenia Using Anthropometry, Bioelectrical Impedance, and Computed Tomography in Surgical Patients with Colorectal Malignancy: Comparison of Agreement Between Methods. AU - Jones,Debra J, AU - Lal,Simon, AU - Strauss,Boyd J, AU - Todd,Chris, AU - Pilling,Mark, AU - Burden,Sorrel T, Y1 - 2019/09/04/ PY - 2019/9/5/pubmed PY - 2019/9/5/medline PY - 2019/9/5/entrez SP - 1074 EP - 1083 JF - Nutrition and cancer JO - Nutr Cancer VL - 72 IS - 6 N2 - Background: Low skeletal muscle index (SMI) and sarcopenia adversely affect clinical outcomes in oncology patients. Study aims were to assess the agreement of bioelectrical impedance analysis (BIA), mid-arm muscle circumference (MAMC), and computed tomography (CT) at the third lumbar vertebra (L3), for the measurement of muscle mass and identification of sarcopenia, in patients with colorectal cancer (CRC).Method: A comparison study of low SMI and sarcopenia determined by BIA and MAMC, compared to CT. Sensitivity, specificity and area under the curve (AUC) were calculated.Results: CT scans were obtained for 100 participants. Low SMI was identified in 29%, 57%, and 20% of participants using CT at L3, BIA, and MAMC, respectively. For low muscle mass BIA showed 60% of participants were correctly classified (AUC 0.619, sensitivity 80%, specificity 52%, kappa 0.241, P = 0.009) and for MAMC, 73% of participants were correctly classified (AUC 0.625, sensitivity 38%, specificity 88%, kappa 0.286, P = 0.005). There were 14%, 31%, and 10% of participants identified as having sarcopenia from CT, BIA, and MAMC, respectively.Conclusions: Both BIA and MAMC show a poor level of agreement for measuring muscle mass compared to CT scans using L3 in patients with CRC. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/31482717/Measurement_of_Muscle_Mass_and_Sarcopenia_Using_Anthropometry_Bioelectrical_Impedance_and_Computed_Tomography_in_Surgical_Patients_with_Colorectal_Malignancy:_Comparison_of_Agreement_Between_Methods_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2019.1659381 DB - PRIME DP - Unbound Medicine ER -
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