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Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study.
J Neurol Sci. 2019 Oct 15; 405:116438.JN

Abstract

OBJECTIVES

To assess microstructural alterations in white matter (WM) in amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI).

METHODS

DTI data were collected from 34 subjects (18 patients with ALS and 16 healthy controls). The atlas-based region of interest (ROI) analysis was conducted to assess WM microstructure in ALS by combining intra-voxel metrics, which included fractional anisotropy (FA) and mean diffusivity (MD), and an inter-voxel metric, i.e., local diffusion homogeneity (LDH). Correlation analysis of diffusion values and clinical factors was also performed.

RESULTS

ALS group showed a significant FA reduction in bilateral corticospinal tract (CST) as well as right uncinate fasciculus (RUF). The areas with higher MD were situated in right corticospinal tract (RCST), left cingulum hippocampus (LCH), RUF, and right superior longitudinal fasciculus (RSLF). Additionally, ALS patients showed decreased LDH in bilateral anterior thalamic radiation (ATR), bilateral CST and left inferior frontal-occipital fasciculus (LIFOF). Significant correlations were observed between ALSFRS-R (revised ALS Functional Rating Scale) scores or progression rate and FA in bilateral CST, as well as between disease duration and LDH in right CST. Receiver operating characteristic (ROC) analysis revealed the feasibility of employing diffusion metrics along the CST to distinguish two groups (AUC = 0.792-0.868, p < .005 for all).

CONCLUSIONS

WM microstructural alteration is a common pathology in ALS, which can be detected by both intra- and inter-voxel diffusion metrics. The extent of abnormalities in several WM tracts such as ATR and LIFOF may be better assessed through the inter-voxel diffusion measurement.

Authors+Show Affiliations

Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China.Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China.Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China.Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China. Electronic address: fmuzzy@163.com.Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China. Electronic address: xueyunjing@126.com.Department of Radiology, Fujian Medical University Union Hospital, Fuzhou 350001, China. Electronic address: chj0075@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31484082

Citation

Du, Xiao-Qiang, et al. "Brain White Matter Abnormalities and Correlation With Severity in Amyotrophic Lateral Sclerosis: an Atlas-based Diffusion Tensor Imaging Study." Journal of the Neurological Sciences, vol. 405, 2019, p. 116438.
Du XQ, Zou TX, Huang NX, et al. Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study. J Neurol Sci. 2019;405:116438.
Du, X. Q., Zou, T. X., Huang, N. X., Zou, Z. Y., Xue, Y. J., & Chen, H. J. (2019). Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study. Journal of the Neurological Sciences, 405, 116438. https://doi.org/10.1016/j.jns.2019.116438
Du XQ, et al. Brain White Matter Abnormalities and Correlation With Severity in Amyotrophic Lateral Sclerosis: an Atlas-based Diffusion Tensor Imaging Study. J Neurol Sci. 2019 Oct 15;405:116438. PubMed PMID: 31484082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain white matter abnormalities and correlation with severity in amyotrophic lateral sclerosis: An atlas-based diffusion tensor imaging study. AU - Du,Xiao-Qiang, AU - Zou,Tian-Xiu, AU - Huang,Nao-Xin, AU - Zou,Zhang-Yu, AU - Xue,Yun-Jing, AU - Chen,Hua-Jun, Y1 - 2019/08/29/ PY - 2019/06/07/received PY - 2019/08/23/revised PY - 2019/08/28/accepted PY - 2019/9/5/pubmed PY - 2020/9/15/medline PY - 2019/9/5/entrez KW - Amyotrophic lateral sclerosis KW - Diffusion tensor imaging KW - Fractional anisotropy KW - Local diffusion homogeneity KW - Mean diffusivity SP - 116438 EP - 116438 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 405 N2 - OBJECTIVES: To assess microstructural alterations in white matter (WM) in amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). METHODS: DTI data were collected from 34 subjects (18 patients with ALS and 16 healthy controls). The atlas-based region of interest (ROI) analysis was conducted to assess WM microstructure in ALS by combining intra-voxel metrics, which included fractional anisotropy (FA) and mean diffusivity (MD), and an inter-voxel metric, i.e., local diffusion homogeneity (LDH). Correlation analysis of diffusion values and clinical factors was also performed. RESULTS: ALS group showed a significant FA reduction in bilateral corticospinal tract (CST) as well as right uncinate fasciculus (RUF). The areas with higher MD were situated in right corticospinal tract (RCST), left cingulum hippocampus (LCH), RUF, and right superior longitudinal fasciculus (RSLF). Additionally, ALS patients showed decreased LDH in bilateral anterior thalamic radiation (ATR), bilateral CST and left inferior frontal-occipital fasciculus (LIFOF). Significant correlations were observed between ALSFRS-R (revised ALS Functional Rating Scale) scores or progression rate and FA in bilateral CST, as well as between disease duration and LDH in right CST. Receiver operating characteristic (ROC) analysis revealed the feasibility of employing diffusion metrics along the CST to distinguish two groups (AUC = 0.792-0.868, p < .005 for all). CONCLUSIONS: WM microstructural alteration is a common pathology in ALS, which can be detected by both intra- and inter-voxel diffusion metrics. The extent of abnormalities in several WM tracts such as ATR and LIFOF may be better assessed through the inter-voxel diffusion measurement. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/31484082/Brain_white_matter_abnormalities_and_correlation_with_severity_in_amyotrophic_lateral_sclerosis:_An_atlas_based_diffusion_tensor_imaging_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(19)30370-3 DB - PRIME DP - Unbound Medicine ER -