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Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice.
Microb Pathog 1988; 5(2):127-39MP

Abstract

The efficacy and mechanisms of protection of two live vaccines and of a protective antigen (PA) vaccine against Bacillus anthracis were studied in inbred mice. Mice that differed in their natural resistance to killing by Sterne, a non-encapsulated, toxigenic vaccine strain of B. anthracis, were used. Vaccination with live Sterne spores protected Sterne-resistant mice against challenge with the virulent Vollum 1B (V1B) strain of B. anthracis, but only at doses of Sterne greater than or equal to 0.1 50% lethal dose. The live B. subtilis recombinant strain PA2, which produces the PA component of anthrax toxin, fully protected (CBA/J) or partially protected (BALB/cJ) Sterne-resistant mice against V1B. Neither immunization with the cell-free PA vaccine nor passive administration of anti-PA antiserum protected Sterne-resistant mice against V1B. Sterne-susceptible A/J mice were not protected against V1B by either live vaccine or by the PA vaccine. However, immunization with strain PA2 induced anti-PA antibody and protected A/J mice against Sterne. A/J mice passively treated with antitoxin antibodies also survived Sterne, and survivors were then partially protected against V1B. Thus, immunity to Sterne correlated with an effective anti-PA response. Immunity to fully virulent V1B also required PA but may involve mechanisms in addition to humoral immunity.

Authors+Show Affiliations

Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21701-5011.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3148815

Citation

Welkos, S L., and A M. Friedlander. "Comparative Safety and Efficacy Against Bacillus Anthracis of Protective Antigen and Live Vaccines in Mice." Microbial Pathogenesis, vol. 5, no. 2, 1988, pp. 127-39.
Welkos SL, Friedlander AM. Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice. Microb Pathog. 1988;5(2):127-39.
Welkos, S. L., & Friedlander, A. M. (1988). Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice. Microbial Pathogenesis, 5(2), pp. 127-39.
Welkos SL, Friedlander AM. Comparative Safety and Efficacy Against Bacillus Anthracis of Protective Antigen and Live Vaccines in Mice. Microb Pathog. 1988;5(2):127-39. PubMed PMID: 3148815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative safety and efficacy against Bacillus anthracis of protective antigen and live vaccines in mice. AU - Welkos,S L, AU - Friedlander,A M, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 127 EP - 39 JF - Microbial pathogenesis JO - Microb. Pathog. VL - 5 IS - 2 N2 - The efficacy and mechanisms of protection of two live vaccines and of a protective antigen (PA) vaccine against Bacillus anthracis were studied in inbred mice. Mice that differed in their natural resistance to killing by Sterne, a non-encapsulated, toxigenic vaccine strain of B. anthracis, were used. Vaccination with live Sterne spores protected Sterne-resistant mice against challenge with the virulent Vollum 1B (V1B) strain of B. anthracis, but only at doses of Sterne greater than or equal to 0.1 50% lethal dose. The live B. subtilis recombinant strain PA2, which produces the PA component of anthrax toxin, fully protected (CBA/J) or partially protected (BALB/cJ) Sterne-resistant mice against V1B. Neither immunization with the cell-free PA vaccine nor passive administration of anti-PA antiserum protected Sterne-resistant mice against V1B. Sterne-susceptible A/J mice were not protected against V1B by either live vaccine or by the PA vaccine. However, immunization with strain PA2 induced anti-PA antibody and protected A/J mice against Sterne. A/J mice passively treated with antitoxin antibodies also survived Sterne, and survivors were then partially protected against V1B. Thus, immunity to Sterne correlated with an effective anti-PA response. Immunity to fully virulent V1B also required PA but may involve mechanisms in addition to humoral immunity. SN - 0882-4010 UR - https://www.unboundmedicine.com/medline/citation/3148815/Comparative_safety_and_efficacy_against_Bacillus_anthracis_of_protective_antigen_and_live_vaccines_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0882-4010(88)90015-0 DB - PRIME DP - Unbound Medicine ER -