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Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey.
Eur J Clin Microbiol Infect Dis. 2019 Dec; 38(12):2355-2364.EJ

Abstract

To investigate the features of paramyxovirus respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (HMPV) infection and determine the effect of meteorological conditions in Guangzhou, a subtropical region of southern China. We collected 11,398 respiratory samples from hospitalized pediatric patients with acute respiratory illness between July 2009 and June 2016 in Guangzhou. The samples were tested simultaneously for 18 respiratory pathogens using real-time PCR. Local meteorological data were also collected for correlation analysis. Of 11,398 patients tested, 5606 (49.2%) patients tested positive for one or more pathogens; RSV, PIV, and HMPV were the first, sixth, and ninth most frequently detected pathogens, in 1690 (14.8%), 502 (4.4%), and 321 (2.8%) patients, respectively. A total 17.9% (4605/5606) of patients with positive results had coinfection with other pathogens. Significant differences were found in the prevalence of RSV, PIV, and HMPV among all age groups (p < 0.001). RSV and HMPV had similar seasonal patterns, with two prevalence peaks every year. PIV appeared alternatively with RSV and HMPV. Multiple linear regression models were established for RSV, PIV, and HMPV prevalence and meteorological factors (p < 0.05). RSV and PIV incidence was negatively correlated with monthly mean relative humidity; RSV and HMPV incidence was negatively correlated with sunshine duration; PIV incidence was positively correlated with mean temperature. We described the features of paramyxovirus infection in a subtropical region of China and highlighted the correlation with meteorological factors. These findings will assist public health authorities and clinicians in improving strategies for controlling paramyxovirus infection.

Authors+Show Affiliations

State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, China.Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, China.State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, China.State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, China.Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, China. zhourong@gird.cn.Scientific Research Center, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China. qianliu_ln@163.com. Department of Pediatrics, Dongguan Eighth People's Hospital, Dongguan, China. qianliu_ln@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31489496

Citation

Liu, Wen-Kuan, et al. "Paramyxoviruses Respiratory Syncytial Virus, Parainfluenza Virus, and Human Metapneumovirus Infection in Pediatric Hospitalized Patients and Climate Correlation in a Subtropical Region of Southern China: a 7-year Survey." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 38, no. 12, 2019, pp. 2355-2364.
Liu WK, Chen DH, Tan WP, et al. Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey. Eur J Clin Microbiol Infect Dis. 2019;38(12):2355-2364.
Liu, W. K., Chen, D. H., Tan, W. P., Qiu, S. Y., Xu, D., Zhang, L., Gu, S. J., Zhou, R., & Liu, Q. (2019). Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 38(12), 2355-2364. https://doi.org/10.1007/s10096-019-03693-x
Liu WK, et al. Paramyxoviruses Respiratory Syncytial Virus, Parainfluenza Virus, and Human Metapneumovirus Infection in Pediatric Hospitalized Patients and Climate Correlation in a Subtropical Region of Southern China: a 7-year Survey. Eur J Clin Microbiol Infect Dis. 2019;38(12):2355-2364. PubMed PMID: 31489496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey. AU - Liu,Wen-Kuan, AU - Chen,De-Hui, AU - Tan,Wei-Ping, AU - Qiu,Shu-Yan, AU - Xu,Duo, AU - Zhang,Li, AU - Gu,Shu-Jun, AU - Zhou,Rong, AU - Liu,Qian, Y1 - 2019/09/05/ PY - 2019/06/13/received PY - 2019/08/26/accepted PY - 2019/9/7/pubmed PY - 2020/2/27/medline PY - 2019/9/7/entrez KW - Acute respiratory illness KW - Epidemiology KW - Human metapneumovirus KW - Meteorological conditions KW - Parainfluenza virus KW - Respiratory syncytial virus SP - 2355 EP - 2364 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur. J. Clin. Microbiol. Infect. Dis. VL - 38 IS - 12 N2 - To investigate the features of paramyxovirus respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (HMPV) infection and determine the effect of meteorological conditions in Guangzhou, a subtropical region of southern China. We collected 11,398 respiratory samples from hospitalized pediatric patients with acute respiratory illness between July 2009 and June 2016 in Guangzhou. The samples were tested simultaneously for 18 respiratory pathogens using real-time PCR. Local meteorological data were also collected for correlation analysis. Of 11,398 patients tested, 5606 (49.2%) patients tested positive for one or more pathogens; RSV, PIV, and HMPV were the first, sixth, and ninth most frequently detected pathogens, in 1690 (14.8%), 502 (4.4%), and 321 (2.8%) patients, respectively. A total 17.9% (4605/5606) of patients with positive results had coinfection with other pathogens. Significant differences were found in the prevalence of RSV, PIV, and HMPV among all age groups (p < 0.001). RSV and HMPV had similar seasonal patterns, with two prevalence peaks every year. PIV appeared alternatively with RSV and HMPV. Multiple linear regression models were established for RSV, PIV, and HMPV prevalence and meteorological factors (p < 0.05). RSV and PIV incidence was negatively correlated with monthly mean relative humidity; RSV and HMPV incidence was negatively correlated with sunshine duration; PIV incidence was positively correlated with mean temperature. We described the features of paramyxovirus infection in a subtropical region of China and highlighted the correlation with meteorological factors. These findings will assist public health authorities and clinicians in improving strategies for controlling paramyxovirus infection. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/31489496/Paramyxoviruses_respiratory_syncytial_virus_parainfluenza_virus_and_human_metapneumovirus_infection_in_pediatric_hospitalized_patients_and_climate_correlation_in_a_subtropical_region_of_southern_China:_a_7_year_survey_ L2 - https://dx.doi.org/10.1007/s10096-019-03693-x DB - PRIME DP - Unbound Medicine ER -