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Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases.
J Zhejiang Univ Sci B 2019 Oct.; 20(10):781-792JZ

Abstract

Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. Bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial-host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments.

Authors+Show Affiliations

State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.School of Medicine, Southeast University, Nanjing 210097, China.Center of Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou 215002, China.State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31489798

Citation

Jia, Er-Teng, et al. "Regulation of Bile Acid Metabolism-related Signaling Pathways By Gut Microbiota in Diseases." Journal of Zhejiang University. Science. B, vol. 20, no. 10, 2019, pp. 781-792.
Jia ET, Liu ZY, Pan M, et al. Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases. J Zhejiang Univ Sci B. 2019;20(10):781-792.
Jia, E. T., Liu, Z. Y., Pan, M., Lu, J. F., & Ge, Q. Y. (2019). Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases. Journal of Zhejiang University. Science. B, 20(10), pp. 781-792. doi:10.1631/jzus.B1900073.
Jia ET, et al. Regulation of Bile Acid Metabolism-related Signaling Pathways By Gut Microbiota in Diseases. J Zhejiang Univ Sci B. 2019;20(10):781-792. PubMed PMID: 31489798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases. AU - Jia,Er-Teng, AU - Liu,Zhi-Yu, AU - Pan,Min, AU - Lu,Jia-Feng, AU - Ge,Qin-Yu, PY - 2019/9/7/entrez PY - 2019/9/7/pubmed PY - 2019/9/7/medline KW - Gut microbiota; Bile acid; Farnesoid X receptor; Vitamin D receptor; Metabolism SP - 781 EP - 792 JF - Journal of Zhejiang University. Science. B JO - J Zhejiang Univ Sci B VL - 20 IS - 10 N2 - Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. Bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial-host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments. SN - 1862-1783 UR - https://www.unboundmedicine.com/medline/citation/31489798/Regulation_of_bile_acid_metabolism-related_signaling_pathways_by_gut_microbiota_in_diseases L2 - http://www.jzus.zju.edu.cn/article.php?doi=10.1631/jzus.B1900073 DB - PRIME DP - Unbound Medicine ER -