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Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis.
Molecules. 2019 Sep 05; 24(18)M

Abstract

The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets. A very important issue is the identification of substandard tablets that do not contain the nominal amounts of the active pharmaceutical ingredient (API), and the differentiation between genuine products and products without any active ingredient or with a false active ingredient. This work presents a novel approach based on fiber-array based Raman hyperspectral imaging to qualify and quantify the antimalarial APIs lumefantrine and artemether directly and non-invasively in a tablet in a time-efficient way. The investigations were carried out with the antimalarial tablet Riamet® and self-made model tablets, which were used as examples of counterfeits and substandard. Partial least-squares regression modeling and density functional theory calculations were carried out for quantification of lumefantrine and artemether and for spectral band assignment. The most prominent differentiating vibrational signatures of the APIs were presented.

Authors+Show Affiliations

Leibniz Institute of Photonic Technology, 07745 Jena, Germany.Leibniz Institute of Photonic Technology, 07745 Jena, Germany.Leibniz Institute of Photonic Technology, 07745 Jena, Germany.Leibniz Institute of Photonic Technology, 07745 Jena, Germany.Leibniz Institute of Photonic Technology, 07745 Jena, Germany.Leibniz Institute of Photonic Technology, 07745 Jena, Germany. Friedrich Schiller University, Institute of Physical Chemistry, 07745 Jena, Germany. Friedrich Schiller University, Abbe Centre of Photonics, 07745 Jena, Germany.Leibniz Institute of Photonic Technology, 07745 Jena, Germany. torsten.frosch@uni-jena.de. Friedrich Schiller University, Institute of Physical Chemistry, 07745 Jena, Germany. torsten.frosch@uni-jena.de. Friedrich Schiller University, Abbe Centre of Photonics, 07745 Jena, Germany. torsten.frosch@uni-jena.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31491881

Citation

Frosch, Timea, et al. "Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® By Means of Raman Hyperspectral Multicomponent Analysis." Molecules (Basel, Switzerland), vol. 24, no. 18, 2019.
Frosch T, Wyrwich E, Yan D, et al. Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis. Molecules. 2019;24(18).
Frosch, T., Wyrwich, E., Yan, D., Domes, C., Domes, R., Popp, J., & Frosch, T. (2019). Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis. Molecules (Basel, Switzerland), 24(18). https://doi.org/10.3390/molecules24183229
Frosch T, et al. Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® By Means of Raman Hyperspectral Multicomponent Analysis. Molecules. 2019 Sep 5;24(18) PubMed PMID: 31491881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis. AU - Frosch,Timea, AU - Wyrwich,Elisabeth, AU - Yan,Di, AU - Domes,Christian, AU - Domes,Robert, AU - Popp,Juergen, AU - Frosch,Torsten, Y1 - 2019/09/05/ PY - 2019/07/21/received PY - 2019/08/31/revised PY - 2019/09/02/accepted PY - 2019/9/8/entrez PY - 2019/9/8/pubmed PY - 2020/1/28/medline KW - API KW - DFT calculations KW - PLSR KW - Raman spectroscopy KW - analytical spectroscopy KW - antimalarial tablets KW - artemether KW - chemometrics KW - counterfeit and substandard pharmaceuticals KW - hyperspectral imaging KW - lumefantrine JF - Molecules (Basel, Switzerland) JO - Molecules VL - 24 IS - 18 N2 - The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets. A very important issue is the identification of substandard tablets that do not contain the nominal amounts of the active pharmaceutical ingredient (API), and the differentiation between genuine products and products without any active ingredient or with a false active ingredient. This work presents a novel approach based on fiber-array based Raman hyperspectral imaging to qualify and quantify the antimalarial APIs lumefantrine and artemether directly and non-invasively in a tablet in a time-efficient way. The investigations were carried out with the antimalarial tablet Riamet® and self-made model tablets, which were used as examples of counterfeits and substandard. Partial least-squares regression modeling and density functional theory calculations were carried out for quantification of lumefantrine and artemether and for spectral band assignment. The most prominent differentiating vibrational signatures of the APIs were presented. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/31491881/Counterfeit_and_Substandard_Test_of_the_Antimalarial_Tablet_Riamet®_by_Means_of_Raman_Hyperspectral_Multicomponent_Analysis_ L2 - https://www.mdpi.com/resolver?pii=molecules24183229 DB - PRIME DP - Unbound Medicine ER -