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[Cholinergic effects of nootropics].
Biomed Biochim Acta. 1988; 47(4-5):417-21.BB

Abstract

With respect to the enhancing effect of nootropics on learning and memory, the influence of some of these drugs on the high affinity choline uptake has been investigated. Meclofenoxate competes with choline uptake in vitro because of its similar side chain; other nootropics are without in vitro effects. A single dose of pramiracetam enhances the choline uptake in cortex and hippocampus. Application of meclofenoxate decreases the uptake of choline. Other nootropics lack acute effects. Possible increases of uptake after repeated dosage disappear within 24 h.

Authors+Show Affiliations

Funk KF
Institut für Pharmakologie und Toxikologie, Medizinische Akademie Carl Gustav Carus, Dresden, DDR.
Schmidt J
No affiliation info available

MeSH

AnimalsBrainCentral Nervous System AgentsCholineFemaleLearningMeclofenoxateMemoryPiracetamPyrithioxinRatsRats, Inbred StrainsReference Values

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

3149192

Citation

Funk, K F., and J Schmidt. "[Cholinergic Effects of Nootropics]." Biomedica Biochimica Acta, vol. 47, no. 4-5, 1988, pp. 417-21.
Funk KF, Schmidt J. [Cholinergic effects of nootropics]. Biomed Biochim Acta. 1988;47(4-5):417-21.
Funk, K. F., & Schmidt, J. (1988). [Cholinergic effects of nootropics]. Biomedica Biochimica Acta, 47(4-5), 417-21.
Funk KF, Schmidt J. [Cholinergic Effects of Nootropics]. Biomed Biochim Acta. 1988;47(4-5):417-21. PubMed PMID: 3149192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cholinergic effects of nootropics]. AU - Funk,K F, AU - Schmidt,J, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 417 EP - 21 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 47 IS - 4-5 N2 - With respect to the enhancing effect of nootropics on learning and memory, the influence of some of these drugs on the high affinity choline uptake has been investigated. Meclofenoxate competes with choline uptake in vitro because of its similar side chain; other nootropics are without in vitro effects. A single dose of pramiracetam enhances the choline uptake in cortex and hippocampus. Application of meclofenoxate decreases the uptake of choline. Other nootropics lack acute effects. Possible increases of uptake after repeated dosage disappear within 24 h. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/3149192/[Cholinergic_effects_of_nootropics]_ DB - PRIME DP - Unbound Medicine ER -