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Authentication of black cohosh (Actaea racemosa) dietary supplements based on chemometric evaluation of hydroxycinnamic acid esters and hydroxycinnamic acid amides.
Anal Bioanal Chem. 2019 Nov; 411(27):7147-7156.AB

Abstract

Ester and amide derivatives of hydroxycinnamic acids are found in black cohosh (Actaea racemosa) and other Actaea plants. These two compound groups were evaluated for authentication of black cohosh dietary supplements. The hydroxycinnamic acid esters (HCAE) were profiled by ultra-performance liquid chromatography-photodiode array detection (UPLC-PDA). The hydroxycinnamic acid amides (HCAA) were acquired simultaneously by mass spectrometry-multiple reaction monitoring (UPLC-MRM) mode. In contrast with the traditional HCAE method using 8 compounds, profiles of HCAA using only 4 feruloyl dopamine-O-hexosides was more convenient for peak by peak comparison. Partial least square discriminant analysis (PLS-DA) was applied to both HCAE and HCAA datasets. Authenticated plant samples of five Actaea species were randomly divided into training and test sets to build and validate the two PLS-DA models. Both models provided reasonable estimates for the classification of A. racemosa and other Actaea plant samples. However, HCAA model performs better in sensitivity, specificity, and accuracy. Assessment of supplement samples provided quite different results for the solid and liquid dietary supplement samples, indicating the dosage form could affect the composition of marker compounds. Graphical abstract.

Authors+Show Affiliations

Methods and Application of Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD, 20705, USA.Methods and Application of Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD, 20705, USA.Methods and Application of Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD, 20705, USA.The North Carolina Arboretum Germplasm Repository, 100 Frederick Law Olmsted Way, Asheville, NC, 28806-9315, USA.Methods and Application of Food Composition Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, 10300 Baltimore Avenue, Beltsville, MD, 20705, USA. james.harnly@usda.gov.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31492999

Citation

Geng, Ping, et al. "Authentication of Black Cohosh (Actaea Racemosa) Dietary Supplements Based On Chemometric Evaluation of Hydroxycinnamic Acid Esters and Hydroxycinnamic Acid Amides." Analytical and Bioanalytical Chemistry, vol. 411, no. 27, 2019, pp. 7147-7156.
Geng P, Chen P, Sun J, et al. Authentication of black cohosh (Actaea racemosa) dietary supplements based on chemometric evaluation of hydroxycinnamic acid esters and hydroxycinnamic acid amides. Anal Bioanal Chem. 2019;411(27):7147-7156.
Geng, P., Chen, P., Sun, J., McCoy, J. H., & Harnly, J. M. (2019). Authentication of black cohosh (Actaea racemosa) dietary supplements based on chemometric evaluation of hydroxycinnamic acid esters and hydroxycinnamic acid amides. Analytical and Bioanalytical Chemistry, 411(27), 7147-7156. https://doi.org/10.1007/s00216-019-02082-9
Geng P, et al. Authentication of Black Cohosh (Actaea Racemosa) Dietary Supplements Based On Chemometric Evaluation of Hydroxycinnamic Acid Esters and Hydroxycinnamic Acid Amides. Anal Bioanal Chem. 2019;411(27):7147-7156. PubMed PMID: 31492999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Authentication of black cohosh (Actaea racemosa) dietary supplements based on chemometric evaluation of hydroxycinnamic acid esters and hydroxycinnamic acid amides. AU - Geng,Ping, AU - Chen,Pei, AU - Sun,Jianghao, AU - McCoy,Joe-Ann H, AU - Harnly,James M, Y1 - 2019/09/06/ PY - 2019/06/05/received PY - 2019/08/16/accepted PY - 2019/07/29/revised PY - 2019/9/8/pubmed PY - 2019/12/18/medline PY - 2019/9/8/entrez KW - Hydroxycinnamic acid amide glycoside KW - Hydroxycinnamic acid ester KW - Nitrogen-containing KW - PLS-DA KW - UPLC-MRM SP - 7147 EP - 7156 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 411 IS - 27 N2 - Ester and amide derivatives of hydroxycinnamic acids are found in black cohosh (Actaea racemosa) and other Actaea plants. These two compound groups were evaluated for authentication of black cohosh dietary supplements. The hydroxycinnamic acid esters (HCAE) were profiled by ultra-performance liquid chromatography-photodiode array detection (UPLC-PDA). The hydroxycinnamic acid amides (HCAA) were acquired simultaneously by mass spectrometry-multiple reaction monitoring (UPLC-MRM) mode. In contrast with the traditional HCAE method using 8 compounds, profiles of HCAA using only 4 feruloyl dopamine-O-hexosides was more convenient for peak by peak comparison. Partial least square discriminant analysis (PLS-DA) was applied to both HCAE and HCAA datasets. Authenticated plant samples of five Actaea species were randomly divided into training and test sets to build and validate the two PLS-DA models. Both models provided reasonable estimates for the classification of A. racemosa and other Actaea plant samples. However, HCAA model performs better in sensitivity, specificity, and accuracy. Assessment of supplement samples provided quite different results for the solid and liquid dietary supplement samples, indicating the dosage form could affect the composition of marker compounds. Graphical abstract. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/31492999/Authentication_of_black_cohosh__Actaea_racemosa__dietary_supplements_based_on_chemometric_evaluation_of_hydroxycinnamic_acid_esters_and_hydroxycinnamic_acid_amides_ L2 - https://dx.doi.org/10.1007/s00216-019-02082-9 DB - PRIME DP - Unbound Medicine ER -