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Coenzyme Q10 Supplementation in Fibrosis and Aging.
Adv Exp Med Biol. 2019; 1178:103-112.AE

Abstract

Coenzyme Q10 (CoQ10) is a vitamin-like substance which functions as an electron carrier within the mitochondrial respiratory chain, as well as serving as an important intracellular antioxidant. Most of the body's CoQ10 requirements are met by endogenous synthesis, although the capacity for CoQ10 production decreases substantially with increasing age. In this article we have reviewed the potential role of CoQ10 supplementation in the treatment of tissue fibrosis, which has been implicated in the age-related loss of function of various organs including the heart. Clinical studies have indicated that CoQ10 supplementation may decrease the level of cardiovascular fibrosis to which older individuals are subjected, and thereby improve cardiovascular function and reduce the risk of cardiovascular associated mortality. Although the factors responsible for the anti-fibrotic action of CoQ10 have yet to be fully elucidated, its antioxidant and anti-inflammatory functions are thought to be major contributors to its clinical efficacy in the treatment of this age-related disorder.

Authors+Show Affiliations

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores, Liverpool, UK. i.hargreaves@ucl.ac.uk.Pharma Nord (UK) Ltd, Morpeth, Newcastle, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31493224

Citation

Hargreaves, Iain P., and David Mantle. "Coenzyme Q10 Supplementation in Fibrosis and Aging." Advances in Experimental Medicine and Biology, vol. 1178, 2019, pp. 103-112.
Hargreaves IP, Mantle D. Coenzyme Q10 Supplementation in Fibrosis and Aging. Adv Exp Med Biol. 2019;1178:103-112.
Hargreaves, I. P., & Mantle, D. (2019). Coenzyme Q10 Supplementation in Fibrosis and Aging. Advances in Experimental Medicine and Biology, 1178, 103-112. https://doi.org/10.1007/978-3-030-25650-0_6
Hargreaves IP, Mantle D. Coenzyme Q10 Supplementation in Fibrosis and Aging. Adv Exp Med Biol. 2019;1178:103-112. PubMed PMID: 31493224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 Supplementation in Fibrosis and Aging. AU - Hargreaves,Iain P, AU - Mantle,David, PY - 2019/9/8/entrez PY - 2019/9/8/pubmed PY - 2019/9/19/medline KW - Cardiovascular disease KW - Coenzyme Q10 KW - Fibrosis KW - Oxidative stress KW - Supplementation SP - 103 EP - 112 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 1178 N2 - Coenzyme Q10 (CoQ10) is a vitamin-like substance which functions as an electron carrier within the mitochondrial respiratory chain, as well as serving as an important intracellular antioxidant. Most of the body's CoQ10 requirements are met by endogenous synthesis, although the capacity for CoQ10 production decreases substantially with increasing age. In this article we have reviewed the potential role of CoQ10 supplementation in the treatment of tissue fibrosis, which has been implicated in the age-related loss of function of various organs including the heart. Clinical studies have indicated that CoQ10 supplementation may decrease the level of cardiovascular fibrosis to which older individuals are subjected, and thereby improve cardiovascular function and reduce the risk of cardiovascular associated mortality. Although the factors responsible for the anti-fibrotic action of CoQ10 have yet to be fully elucidated, its antioxidant and anti-inflammatory functions are thought to be major contributors to its clinical efficacy in the treatment of this age-related disorder. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/31493224/Coenzyme_Q10_Supplementation_in_Fibrosis_and_Aging_ L2 - https://dx.doi.org/10.1007/978-3-030-25650-0_6 DB - PRIME DP - Unbound Medicine ER -
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