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Evaluation of protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside against mercuric chloride-induced nephrotoxicity in rats.
Mol Biol Rep 2019; 46(6):6171-6179MB

Abstract

The toxicity of heavy metals such as mercury (Hg) in humans and animals is well documented. The kidney is the primary deposition site of inorganic-Hg and target organ of its toxicity. The present study investigated the protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside (SDG) on nephrotoxicity induced by mercuric chloride (HgCl2). Rats were intraperitoneally injected with HgCl2 (2 mg/kg/day) and renal toxicity was induced. Subcutaneous administration of rats with SDG (5 mg/kg/day) as a pre-treatment caused a significant reversal of HgCl2 induced increase in blood urea, creatinine, glutathione s-transferase and catalase (CAT). On the other hand, administration of SDG with HgCl2 restored normal levels of albumin and superoxide dismutase (SOD). Histological examination of kidneys confirmed that pre-treatment of SDG before HgCl2 administration significantly reduced its pathological effects. Thus, the results of the present investigation suggest that SDG can significantly reduce renal damage, serum and tissue biochemical profiles caused by HgCl2 induced nephrotoxicity. Hence, SDG may be recommended for clinical trials in the treatment of kidney disorders caused by exposure to Hg.

Authors+Show Affiliations

Department of Biochemistry, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, 570005, India.Department of Biochemistry, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, 570005, India.Department of Basic Science, Biology Unit Deanship of Preparatory Year and Supporting studies, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 34212, Saudi Arabia.Department of Basic Science, Biology Unit Deanship of Preparatory Year and Supporting studies, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 34212, Saudi Arabia.Department of Biochemistry, Yuvaraja's College, University of Mysore, Mysuru, Karnataka, 570005, India. rajeshj11@rediffmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31493285

Citation

Aqeel, Tareq, et al. "Evaluation of Protective Efficacy of Flaxseed lignan-Secoisolariciresinol Diglucoside Against Mercuric Chloride-induced Nephrotoxicity in Rats." Molecular Biology Reports, vol. 46, no. 6, 2019, pp. 6171-6179.
Aqeel T, Chikkalakshmipura Gurumallu S, Hashimi SM, et al. Evaluation of protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside against mercuric chloride-induced nephrotoxicity in rats. Mol Biol Rep. 2019;46(6):6171-6179.
Aqeel, T., Chikkalakshmipura Gurumallu, S., Hashimi, S. M., AlQurashi, N., & Javaraiah, R. (2019). Evaluation of protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside against mercuric chloride-induced nephrotoxicity in rats. Molecular Biology Reports, 46(6), pp. 6171-6179. doi:10.1007/s11033-019-05052-7.
Aqeel T, et al. Evaluation of Protective Efficacy of Flaxseed lignan-Secoisolariciresinol Diglucoside Against Mercuric Chloride-induced Nephrotoxicity in Rats. Mol Biol Rep. 2019;46(6):6171-6179. PubMed PMID: 31493285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside against mercuric chloride-induced nephrotoxicity in rats. AU - Aqeel,Tareq, AU - Chikkalakshmipura Gurumallu,Sunil, AU - Hashimi,Saeed Mujahid, AU - AlQurashi,Naif, AU - Javaraiah,Rajesh, Y1 - 2019/09/06/ PY - 2019/04/14/received PY - 2019/08/28/accepted PY - 2019/9/8/pubmed PY - 2019/9/8/medline PY - 2019/9/8/entrez KW - Flaxseed lignan KW - Mercuric chloride KW - Nephrotoxicity KW - Oxidative stress KW - Secoisolariciresinol diglucoside SP - 6171 EP - 6179 JF - Molecular biology reports JO - Mol. Biol. Rep. VL - 46 IS - 6 N2 - The toxicity of heavy metals such as mercury (Hg) in humans and animals is well documented. The kidney is the primary deposition site of inorganic-Hg and target organ of its toxicity. The present study investigated the protective efficacy of flaxseed lignan-Secoisolariciresinol diglucoside (SDG) on nephrotoxicity induced by mercuric chloride (HgCl2). Rats were intraperitoneally injected with HgCl2 (2 mg/kg/day) and renal toxicity was induced. Subcutaneous administration of rats with SDG (5 mg/kg/day) as a pre-treatment caused a significant reversal of HgCl2 induced increase in blood urea, creatinine, glutathione s-transferase and catalase (CAT). On the other hand, administration of SDG with HgCl2 restored normal levels of albumin and superoxide dismutase (SOD). Histological examination of kidneys confirmed that pre-treatment of SDG before HgCl2 administration significantly reduced its pathological effects. Thus, the results of the present investigation suggest that SDG can significantly reduce renal damage, serum and tissue biochemical profiles caused by HgCl2 induced nephrotoxicity. Hence, SDG may be recommended for clinical trials in the treatment of kidney disorders caused by exposure to Hg. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/31493285/Evaluation_of_protective_efficacy_of_flaxseed_lignan-Secoisolariciresinol_diglucoside_against_mercuric_chloride-induced_nephrotoxicity_in_rats L2 - https://doi.org/10.1007/s11033-019-05052-7 DB - PRIME DP - Unbound Medicine ER -