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Experimental models assessing bilirubin neurotoxicity.

Abstract

The molecular and cellular events leading to bilirubin-induced neurotoxicity, the mechanisms regulating liver and intestine expression in neonates, and alternative pathways of bilirubin catabolism remain incompletely defined. To answer these questions, researchers have developed a number of model systems to closely recapitulate the main characteristics of the disease, ranging from tissue cultures to engineered mouse models. In the present review we describe in vitro, ex vivo, and in vivo models developed to study bilirubin metabolism and neurotoxicity, with a special focus on the use of engineered animal models. In addition, we discussed the most recent studies related to potential therapeutic approaches to treat neonatal hyperbilirubinemia, ranging from anti-inflammatory drugs, activation of nuclear receptor pathways, blockade of bilirubin catabolism, and stimulation of alternative bilirubin-disposal pathways.

Authors+Show Affiliations

International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano, 99, 34149, Trieste, Italy.International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano, 99, 34149, Trieste, Italy. muro@icgeb.org.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31493769

Citation

Bortolussi, Giulia, and Andrés F. Muro. "Experimental Models Assessing Bilirubin Neurotoxicity." Pediatric Research, 2019.
Bortolussi G, Muro AF. Experimental models assessing bilirubin neurotoxicity. Pediatr Res. 2019.
Bortolussi, G., & Muro, A. F. (2019). Experimental models assessing bilirubin neurotoxicity. Pediatric Research, doi:10.1038/s41390-019-0570-x.
Bortolussi G, Muro AF. Experimental Models Assessing Bilirubin Neurotoxicity. Pediatr Res. 2019 Sep 7; PubMed PMID: 31493769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental models assessing bilirubin neurotoxicity. AU - Bortolussi,Giulia, AU - Muro,Andrés F, Y1 - 2019/09/07/ PY - 2019/05/17/received PY - 2019/08/16/accepted PY - 2019/07/29/revised PY - 2019/9/8/pubmed PY - 2019/9/8/medline PY - 2019/9/8/entrez JF - Pediatric research JO - Pediatr. Res. N2 - The molecular and cellular events leading to bilirubin-induced neurotoxicity, the mechanisms regulating liver and intestine expression in neonates, and alternative pathways of bilirubin catabolism remain incompletely defined. To answer these questions, researchers have developed a number of model systems to closely recapitulate the main characteristics of the disease, ranging from tissue cultures to engineered mouse models. In the present review we describe in vitro, ex vivo, and in vivo models developed to study bilirubin metabolism and neurotoxicity, with a special focus on the use of engineered animal models. In addition, we discussed the most recent studies related to potential therapeutic approaches to treat neonatal hyperbilirubinemia, ranging from anti-inflammatory drugs, activation of nuclear receptor pathways, blockade of bilirubin catabolism, and stimulation of alternative bilirubin-disposal pathways. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/31493769/Experimental_models_assessing_bilirubin_neurotoxicity L2 - http://dx.doi.org/10.1038/s41390-019-0570-x DB - PRIME DP - Unbound Medicine ER -