Tags

Type your tag names separated by a space and hit enter

Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls.
Neuropsychiatr Dis Treat 2019; 15:2213-2219ND

Abstract

Objective

We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls.

Materials and methods

Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-IV-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters.

Results

The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations.

Conclusion

Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD.

Authors+Show Affiliations

Department of Child and Adolescent Psychiatry, Düzce Üniversitesi, Düzce, Turkey.Department of Medical Biochemistry, Faculty of Medicine, Düzce Üniversitesi, Düzce, Turkey.Department of Child and Adolescent Psychiatry, Acıbadem Üniversitesi Tıp Fakültesi, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31496704

Citation

Yektaş, Çiğdem, et al. "Comparison of Serum B12, Folate and Homocysteine Concentrations in Children With Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder and Healthy Controls." Neuropsychiatric Disease and Treatment, vol. 15, 2019, pp. 2213-2219.
Yektaş Ç, Alpay M, Tufan AE. Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls. Neuropsychiatr Dis Treat. 2019;15:2213-2219.
Yektaş, Ç., Alpay, M., & Tufan, A. E. (2019). Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls. Neuropsychiatric Disease and Treatment, 15, pp. 2213-2219. doi:10.2147/NDT.S212361.
Yektaş Ç, Alpay M, Tufan AE. Comparison of Serum B12, Folate and Homocysteine Concentrations in Children With Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder and Healthy Controls. Neuropsychiatr Dis Treat. 2019;15:2213-2219. PubMed PMID: 31496704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls. AU - Yektaş,Çiğdem, AU - Alpay,Merve, AU - Tufan,Ali Evren, Y1 - 2019/08/06/ PY - 2019/04/15/received PY - 2019/06/10/accepted PY - 2019/9/10/entrez PY - 2019/9/10/pubmed PY - 2019/9/10/medline KW - attention deficit hyperactivity disorder KW - autism spectrum disorder KW - folate KW - homocysteine KW - vitamin B12 SP - 2213 EP - 2219 JF - Neuropsychiatric disease and treatment JO - Neuropsychiatr Dis Treat VL - 15 N2 - Objective: We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls. Materials and methods: Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-IV-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters. Results: The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations. Conclusion: Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD. SN - 1176-6328 UR - https://www.unboundmedicine.com/medline/citation/31496704/Comparison_of_serum_B12_folate_and_homocysteine_concentrations_in_children_with_autism_spectrum_disorder_or_attention_deficit_hyperactivity_disorder_and_healthy_controls_ L2 - https://dx.doi.org/10.2147/NDT.S212361 DB - PRIME DP - Unbound Medicine ER -