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Leptospirosis With Acute Renal Failure and Vasculitis: A Case Report.
Arch Rheumatol 2019; 34(2):229-232AR

Abstract

Leptospirosis is a zoonotic disease that occurs worldwide. Various clinical manifestations of leptospirosis can be seen. In this article, we present a case with acute renal failure, severe vasculitis and hyperbilirubinemia occurring simultaneously with leptospirosis. A 45-year-old male patient presented with fever, myalgia, jaundice and reddish skin lesions and anuria. Physical examination findings were icteric sclera, large tender hepatomegaly, and lower extremities' cutaneous necrosis due to vasculitis. Hemodialysis was started. Kidney biopsy revealed degenerative changes of proximal tubules, some of them containing bile casts. Microscopic agglutination test was positive and consistent with leptospirosis. Intravenous ampicillin and oral tetracycline were started. Methylprednisolone 60 mg per day was given for skin vasculitis. Hemodialysis therapy was discontinued. All clinical findings gradually regressed.

Authors+Show Affiliations

Department of Nephrology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Nephrology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Nephrology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Nephrology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.Department of Nephrology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31497771

Citation

Yücel Koçak, Sibel, et al. "Leptospirosis With Acute Renal Failure and Vasculitis: a Case Report." Archives of Rheumatology, vol. 34, no. 2, 2019, pp. 229-232.
Yücel Koçak S, Kudu A, Kayalar A, et al. Leptospirosis With Acute Renal Failure and Vasculitis: A Case Report. Arch Rheumatol. 2019;34(2):229-232.
Yücel Koçak, S., Kudu, A., Kayalar, A., Yilmaz, M., & Apaydin, S. (2019). Leptospirosis With Acute Renal Failure and Vasculitis: A Case Report. Archives of Rheumatology, 34(2), pp. 229-232. doi:10.5606/ArchRheumatol.2019.7063.
Yücel Koçak S, et al. Leptospirosis With Acute Renal Failure and Vasculitis: a Case Report. Arch Rheumatol. 2019;34(2):229-232. PubMed PMID: 31497771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptospirosis With Acute Renal Failure and Vasculitis: A Case Report. AU - Yücel Koçak,Sibel, AU - Kudu,Ayşegül, AU - Kayalar,Arzu, AU - Yilmaz,Mürvet, AU - Apaydin,Süheyla, Y1 - 2018/11/30/ PY - 2018/06/05/received PY - 2018/09/28/accepted PY - 2019/9/10/entrez PY - 2019/9/10/pubmed PY - 2019/9/10/medline KW - Leptospirosis KW - Weil's disease KW - renal failure KW - vasculitis SP - 229 EP - 232 JF - Archives of rheumatology JO - Arch Rheumatol VL - 34 IS - 2 N2 - Leptospirosis is a zoonotic disease that occurs worldwide. Various clinical manifestations of leptospirosis can be seen. In this article, we present a case with acute renal failure, severe vasculitis and hyperbilirubinemia occurring simultaneously with leptospirosis. A 45-year-old male patient presented with fever, myalgia, jaundice and reddish skin lesions and anuria. Physical examination findings were icteric sclera, large tender hepatomegaly, and lower extremities' cutaneous necrosis due to vasculitis. Hemodialysis was started. Kidney biopsy revealed degenerative changes of proximal tubules, some of them containing bile casts. Microscopic agglutination test was positive and consistent with leptospirosis. Intravenous ampicillin and oral tetracycline were started. Methylprednisolone 60 mg per day was given for skin vasculitis. Hemodialysis therapy was discontinued. All clinical findings gradually regressed. SN - 2618-6500 UR - https://www.unboundmedicine.com/medline/citation/31497771/Leptospirosis_With_Acute_Renal_Failure_and_Vasculitis:_A_Case_Report L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31497771/ DB - PRIME DP - Unbound Medicine ER -