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Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine [Formula: see text].
J Cutan Med Surg. 2019 Nov/Dec; 23(6):608-612.JC

Abstract

BACKGROUND

Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a relatively newly recognized clinical entity that typically presents with predominant mucositis accompanied by variable cutaneous involvement 7-9 days after the onset of prodromal symptoms. There are no evidence-based guidelines for treatment, and current standards of care may include supportive therapy, antibiotics, corticosteroids, and intravenous immunoglobulin .

OBJECTIVE

This case series aims to describe the potential efficacy of cyclosporine A (CsA) in the treatment of MIRM.

METHODS

The present case series details our use of CsA early in the course of MIRM in 3 pediatric patients.

RESULTS

Rapid clinical resolution was observed following CsA therapy.

CONCLUSIONS

We suggest that early initiation of CsA may be an effective therapeutic option for MIRM.

Links

Publisher Full Text
journals.sagepub.com
dx.doi.org
Aggregator Full Text

Authors+Show Affiliations

Li HO
Faculty of Medicine, University of Ottawa, Ontario, Canada.
Colantonio S
Faculty of Medicine, University of Ottawa, Ontario, Canada.
Ramien ML
Division of Rheumatology and Dermatology, Children's Hospital of Eastern Ontario, Ottawa, Canada. Division of Community Pediatrics, Alberta Children's Hospital, Calgary, AB, Canada.

MeSH

AdolescentAnti-Bacterial AgentsChild, PreschoolCyclosporineExanthemaEyeFemaleHumansMaleMouthMucositisMycoplasma pneumoniaePneumonia, MycoplasmaSkinStevens-Johnson Syndrome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31502864

Citation

Li, Heidi Oi-Yee, et al. "Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine [Formula: See Text]." Journal of Cutaneous Medicine and Surgery, vol. 23, no. 6, 2019, pp. 608-612.
Li HO, Colantonio S, Ramien ML. Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine [Formula: see text]. J Cutan Med Surg. 2019;23(6):608-612.
Li, H. O., Colantonio, S., & Ramien, M. L. (2019). Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine [Formula: see text]. Journal of Cutaneous Medicine and Surgery, 23(6), 608-612. https://doi.org/10.1177/1203475419874444
Li HO, Colantonio S, Ramien ML. Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine [Formula: See Text]. J Cutan Med Surg. 2019 Nov/Dec;23(6):608-612. PubMed PMID: 31502864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Mycoplasma pneumoniae-Induced Rash and Mucositis With Cyclosporine [Formula: see text]. AU - Li,Heidi Oi-Yee, AU - Colantonio,Sophia, AU - Ramien,Michele L, Y1 - 2019/09/10/ PY - 2019/9/11/pubmed PY - 2020/8/25/medline PY - 2019/9/11/entrez KW - Fuchs syndrome KW - MIRM KW - MPAM KW - Mycoplasma pneumoniae-associated mucositis KW - Mycoplasma pneumoniae-induced rash and mucositis KW - SJS KW - Stevens-Johnson syndrome KW - case series KW - cyclosporine KW - cyclosporine A KW - mucositis KW - mycoplasma KW - pediatric KW - therapeutics SP - 608 EP - 612 JF - Journal of cutaneous medicine and surgery JO - J Cutan Med Surg VL - 23 IS - 6 N2 - BACKGROUND: Mycoplasma pneumoniae-induced rash and mucositis (MIRM) is a relatively newly recognized clinical entity that typically presents with predominant mucositis accompanied by variable cutaneous involvement 7-9 days after the onset of prodromal symptoms. There are no evidence-based guidelines for treatment, and current standards of care may include supportive therapy, antibiotics, corticosteroids, and intravenous immunoglobulin . OBJECTIVE: This case series aims to describe the potential efficacy of cyclosporine A (CsA) in the treatment of MIRM. METHODS: The present case series details our use of CsA early in the course of MIRM in 3 pediatric patients. RESULTS: Rapid clinical resolution was observed following CsA therapy. CONCLUSIONS: We suggest that early initiation of CsA may be an effective therapeutic option for MIRM. SN - 1615-7109 UR - https://www.unboundmedicine.com/medline/citation/31502864/Treatment_of_Mycoplasma_pneumoniae_Induced_Rash_and_Mucositis_With_Cyclosporine_[Formula:_see_text]_ L2 - https://journals.sagepub.com/doi/10.1177/1203475419874444?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -