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Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA: can one tracer replace the other?
Scand J Clin Lab Invest. 2019 Nov; 79(7):463-467.SJ

Abstract

Both 99mTc-DTPA and 51Cr-EDTA are widely used to determine glomerular filtration rate (GFR), but few direct comparative studies exist. The shortage of 51Cr-EDTA makes a direct comparison highly relevant. The aim of the study was to investigate if there is any clinically relevant difference between plasma clearance of 99mTc-DTPA and 51Cr-EDTA. Patients ≥18 years of age referred for routine GFR measurement by 51Cr-EDTA were prospectively enrolled. The two tracers (10 MBq 99mTc-DTPA (CaNa3-DTPA) and 2.5 MBq 51Cr-EDTA) were intravenously injected at time zero. A standard 4-sample technique was applied with samples collected at 180, 200, 220 and 240 min, if the estimated GFR (eGFR) was ≥30 mL/min. A comparison of single-sample GFR based on the 200 min sample was also conducted. Fifty-six patients were enrolled in the study. All patients had an estimated GFR >30 mL/min/1.73 m2. No patients suffered from ascites or significant oedema. The mean 51Cr-EDTA plasma clearance was 82 mL/min (range 16-226). The plasma clearances determined by the two methods were highly correlated (r = 0.993). The plasma clearance was significantly higher when measured by 99mTc-DTPA than by 51Cr-EDTA (p = 0.01), but the numerical difference was minimal (mean difference 1.4 mL/min; 95% limits of agreement (LOA) -6.6 to 9.4). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of 99mTc-DTPA and that of 51Cr-EDTA. Therefore, 99mTc-DTPA can replace 51Cr-EDTA when needed.

Authors+Show Affiliations

Department of Nuclear Medicine, Aalborg University Hospital , Aalborg , Denmark.Department of Nuclear Medicine, Aalborg University Hospital , Aalborg , Denmark.Department of Nuclear Medicine, Aalborg University Hospital , Aalborg , Denmark.Department of Nuclear Medicine, Aalborg University Hospital , Aalborg , Denmark. Department of Clinical Medicine, University of Aalborg , Aalborg , Denmark.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31502901

Citation

Andersen, Trine B., et al. "Comparison of Simultaneous Plasma Clearance of 99mTc-DTPA and 51Cr-EDTA: Can One Tracer Replace the Other?" Scandinavian Journal of Clinical and Laboratory Investigation, vol. 79, no. 7, 2019, pp. 463-467.
Andersen TB, Jødal L, Nielsen NS, et al. Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA: can one tracer replace the other? Scand J Clin Lab Invest. 2019;79(7):463-467.
Andersen, T. B., Jødal, L., Nielsen, N. S., & Petersen, L. J. (2019). Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA: can one tracer replace the other? Scandinavian Journal of Clinical and Laboratory Investigation, 79(7), 463-467. https://doi.org/10.1080/00365513.2019.1658217
Andersen TB, et al. Comparison of Simultaneous Plasma Clearance of 99mTc-DTPA and 51Cr-EDTA: Can One Tracer Replace the Other. Scand J Clin Lab Invest. 2019;79(7):463-467. PubMed PMID: 31502901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of simultaneous plasma clearance of 99mTc-DTPA and 51Cr-EDTA: can one tracer replace the other? AU - Andersen,Trine B, AU - Jødal,Lars, AU - Nielsen,Nikolaj S, AU - Petersen,Lars J, Y1 - 2019/09/10/ PY - 2019/9/11/pubmed PY - 2020/6/9/medline PY - 2019/9/11/entrez KW - 51Cr-EDTA KW - 99mTcDTPA KW - GFR KW - glomerular filtration rate KW - plasma clearance KW - renal function SP - 463 EP - 467 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 79 IS - 7 N2 - Both 99mTc-DTPA and 51Cr-EDTA are widely used to determine glomerular filtration rate (GFR), but few direct comparative studies exist. The shortage of 51Cr-EDTA makes a direct comparison highly relevant. The aim of the study was to investigate if there is any clinically relevant difference between plasma clearance of 99mTc-DTPA and 51Cr-EDTA. Patients ≥18 years of age referred for routine GFR measurement by 51Cr-EDTA were prospectively enrolled. The two tracers (10 MBq 99mTc-DTPA (CaNa3-DTPA) and 2.5 MBq 51Cr-EDTA) were intravenously injected at time zero. A standard 4-sample technique was applied with samples collected at 180, 200, 220 and 240 min, if the estimated GFR (eGFR) was ≥30 mL/min. A comparison of single-sample GFR based on the 200 min sample was also conducted. Fifty-six patients were enrolled in the study. All patients had an estimated GFR >30 mL/min/1.73 m2. No patients suffered from ascites or significant oedema. The mean 51Cr-EDTA plasma clearance was 82 mL/min (range 16-226). The plasma clearances determined by the two methods were highly correlated (r = 0.993). The plasma clearance was significantly higher when measured by 99mTc-DTPA than by 51Cr-EDTA (p = 0.01), but the numerical difference was minimal (mean difference 1.4 mL/min; 95% limits of agreement (LOA) -6.6 to 9.4). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of 99mTc-DTPA and that of 51Cr-EDTA. Therefore, 99mTc-DTPA can replace 51Cr-EDTA when needed. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/31502901/Comparison_of_simultaneous_plasma_clearance_of_99mTc_DTPA_and_51Cr_EDTA:_can_one_tracer_replace_the_other L2 - https://www.tandfonline.com/doi/full/10.1080/00365513.2019.1658217 DB - PRIME DP - Unbound Medicine ER -