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Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated with a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians.
J Nutr 2019JN

Abstract

BACKGROUND

Vitamin K (VK) exists in the form of phylloquinone (PK) and menaquinones (MKs). Roles of VK on cognitive health in the elderly are emerging, but there is limited evidence on VK uptake and metabolism in human brain.

OBJECTIVES

The primary objective of this study was to characterize VK distribution in brains of an elderly population with varied cognitive function. In addition, associations among circulating (a biomarker of VK intake) and cerebral VK concentrations and cognition were investigated.

METHODS

Serum or plasma (n = 27) and brain samples from the frontal cortex (FC; n = 46) and the temporal cortex (TC; n = 33) were acquired from 48 decedents (aged 98-107 y; 25 demented and 23 nondemented) enrolled in the Georgia Centenarian Study. Both circulating and brain VK concentrations were measured using HPLC with fluorescence detection. Cognitive assessment was performed within 1 y prior to mortality. Partial correlations between serum/plasma or cerebral VK concentrations and cognitive function were performed, adjusting for covariates and separating by dementia and antithrombotic use.

RESULTS

MK-4 was the predominant vitamer in both FC (mean ± SD = 4.92 ± 2.31 pmol/g, ≥89.15% ± 5.09% of total VK) and TC (4.60 ± 2.11 pmol/g, ≥89.71% ± 4.43% of total VK) regardless of cognitive status. Antithrombotic users had 34.0% and 53.9% lower MK-4 concentrations in FC (P < 0.05) and TC (P < 0.001), respectively. Circulating PK was not correlated with cerebral MK-4 or total VK concentrations. Circulating PK concentrations were significantly associated with a wide range of cognitive measures in nondemented centenarians (P < 0.05). In contrast, cerebral MK-4 concentrations were not associated with cognitive performance, either before or after exclusion of antithrombotic users.

CONCLUSIONS

Circulating VK concentrations are not related to cerebral MK-4 concentrations in centenarians. Cerebral MK-4 concentrations are tightly regulated over a range of VK intakes and cognitive function. Circulating PK may reflect intake of VK-rich foods containing other dietary components beneficial to cognitive health. Further investigation of VK uptake and metabolism in the brain is warranted.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.Department of Nutrition, University of Montreal, Montreal, Canada.Department of Nutrition and Health Sciences, University of Nebraska Lincoln, Lincoln, NE, USA.Institute of Gerontology, University of Georgia, Athens, GA, USA.Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31504672

Citation

Tanprasertsuk, Jirayu, et al. "Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated With a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians." The Journal of Nutrition, 2019.
Tanprasertsuk J, Ferland G, Johnson MA, et al. Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated with a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians. J Nutr. 2019.
Tanprasertsuk, J., Ferland, G., Johnson, M. A., Poon, L. W., Scott, T. M., Barbey, A. K., ... Johnson, E. J. (2019). Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated with a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians. The Journal of Nutrition, doi:10.1093/jn/nxz200.
Tanprasertsuk J, et al. Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated With a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians. J Nutr. 2019 Aug 28; PubMed PMID: 31504672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concentrations of Circulating Phylloquinone, but Not Cerebral Menaquinone-4, Are Positively Correlated with a Wide Range of Cognitive Measures: Exploratory Findings in Centenarians. AU - Tanprasertsuk,Jirayu, AU - Ferland,Guylaine, AU - Johnson,Mary Ann, AU - Poon,Leonard W, AU - Scott,Tammy M, AU - Barbey,Aron K, AU - Barger,Kathryn, AU - Wang,Xiang-Dong, AU - Johnson,Elizabeth J, Y1 - 2019/08/28/ PY - 2019/05/05/received PY - 2019/05/16/revised PY - 2019/07/25/accepted PY - 2019/9/11/entrez PY - 2019/9/11/pubmed PY - 2019/9/11/medline KW - cognition KW - menaquinone KW - older adults KW - phylloquinone KW - vitamin K JF - The Journal of nutrition JO - J. Nutr. N2 - BACKGROUND: Vitamin K (VK) exists in the form of phylloquinone (PK) and menaquinones (MKs). Roles of VK on cognitive health in the elderly are emerging, but there is limited evidence on VK uptake and metabolism in human brain. OBJECTIVES: The primary objective of this study was to characterize VK distribution in brains of an elderly population with varied cognitive function. In addition, associations among circulating (a biomarker of VK intake) and cerebral VK concentrations and cognition were investigated. METHODS: Serum or plasma (n = 27) and brain samples from the frontal cortex (FC; n = 46) and the temporal cortex (TC; n = 33) were acquired from 48 decedents (aged 98-107 y; 25 demented and 23 nondemented) enrolled in the Georgia Centenarian Study. Both circulating and brain VK concentrations were measured using HPLC with fluorescence detection. Cognitive assessment was performed within 1 y prior to mortality. Partial correlations between serum/plasma or cerebral VK concentrations and cognitive function were performed, adjusting for covariates and separating by dementia and antithrombotic use. RESULTS: MK-4 was the predominant vitamer in both FC (mean ± SD = 4.92 ± 2.31 pmol/g, ≥89.15% ± 5.09% of total VK) and TC (4.60 ± 2.11 pmol/g, ≥89.71% ± 4.43% of total VK) regardless of cognitive status. Antithrombotic users had 34.0% and 53.9% lower MK-4 concentrations in FC (P < 0.05) and TC (P < 0.001), respectively. Circulating PK was not correlated with cerebral MK-4 or total VK concentrations. Circulating PK concentrations were significantly associated with a wide range of cognitive measures in nondemented centenarians (P < 0.05). In contrast, cerebral MK-4 concentrations were not associated with cognitive performance, either before or after exclusion of antithrombotic users. CONCLUSIONS: Circulating VK concentrations are not related to cerebral MK-4 concentrations in centenarians. Cerebral MK-4 concentrations are tightly regulated over a range of VK intakes and cognitive function. Circulating PK may reflect intake of VK-rich foods containing other dietary components beneficial to cognitive health. Further investigation of VK uptake and metabolism in the brain is warranted. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/31504672/Concentrations_of_Circulating_Phylloquinone,_but_Not_Cerebral_Menaquinone-4,_Are_Positively_Correlated_with_a_Wide_Range_of_Cognitive_Measures:_Exploratory_Findings_in_Centenarians L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxz200 DB - PRIME DP - Unbound Medicine ER -