Tags

Type your tag names separated by a space and hit enter

Can dietary jujube (Ziziphus jujuba Mill.) fruit extract alter cutaneous mucosal immunity, immune related genes expression in skin and growth performance of common carp (Cyprinus carpio)?
Fish Shellfish Immunol. 2019 Nov; 94:705-710.FS

Abstract

The present study investigates the effect of dietary Ziziphus jujube fruit extract [ZJFE] on skin mucus non-specific immune parameters as well as mRNA levels of immune related gene in the skin of common carp fingerlings. An eight-week feeding trial was performed using different levels of dietary ZJFE (0, 0.25, 0.5 and 1%). At the end of the trial skin mucus immune parameters (total Ig, lysozyme and protease activity), cytokines genes (il1b, il8, il10 and tnf-alpha) expression in skin and growth performance were studied. The result showed highest and lowest skin mucus total Ig were observed in fish fed diet containing 0.5% ZJFE and control group, respectively (P < 0.05). There were no significant difference among treatments regarding skin mucus lysozyme activity (P >0.05). It should be noted that, feeding on 0.5 and 1% ZJFE significantly increased skin mucus protease activity (P <0.05). Likewise, gene expression studies in skin showed significant increase of il1b expression in fish fed 0.5% ZJFE compared other treatments (P <0.05). Also, il8 gene was noticeably up-regulated in 0.5 and 1% treatments compared to the control group (P <0.05). While there were no significant difference between 0.25% JFE treatment and control in case of relative il10 gene expression (P >0.05), feeding on diets containing 0.5% or 1% ZJFE significantly down-regulated il10 gene (P <0.05). Our study indicated that relative expression of tnf-alpha gene significantly increased in treated groups (P <0.05). Also, feeding on ZJFE supplemented diet improved growth performance parameters. Overall, this experiment demonstrated the potentially useful effects of ZJFE on skin mucosal immunity and performance of common carp fingerlings.

Authors+Show Affiliations

Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address: hienqbuni@gmail.com.Department of Zoology, Pachaiyappa's College for Men, Kanchipuram, 631 501, Tamil Nadu, India.Department of Veterinary Medicine, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St, Moscow, 117198, Russian Federation.Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.Department of Fisheries, Faculty of Natural Resources, University of Zabol, Zabol, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31505247

Citation

Hoseinifar, Seyed Hossein, et al. "Can Dietary Jujube (Ziziphus Jujuba Mill.) Fruit Extract Alter Cutaneous Mucosal Immunity, Immune Related Genes Expression in Skin and Growth Performance of Common Carp (Cyprinus Carpio)?" Fish & Shellfish Immunology, vol. 94, 2019, pp. 705-710.
Hoseinifar SH, Khodadadian Zou H, Van Doan H, et al. Can dietary jujube (Ziziphus jujuba Mill.) fruit extract alter cutaneous mucosal immunity, immune related genes expression in skin and growth performance of common carp (Cyprinus carpio)? Fish Shellfish Immunol. 2019;94:705-710.
Hoseinifar, S. H., Khodadadian Zou, H., Van Doan, H., Harikrishnan, R., Yousefi, M., Paknejad, H., & Ahmadifar, E. (2019). Can dietary jujube (Ziziphus jujuba Mill.) fruit extract alter cutaneous mucosal immunity, immune related genes expression in skin and growth performance of common carp (Cyprinus carpio)? Fish & Shellfish Immunology, 94, 705-710. https://doi.org/10.1016/j.fsi.2019.09.016
Hoseinifar SH, et al. Can Dietary Jujube (Ziziphus Jujuba Mill.) Fruit Extract Alter Cutaneous Mucosal Immunity, Immune Related Genes Expression in Skin and Growth Performance of Common Carp (Cyprinus Carpio). Fish Shellfish Immunol. 2019;94:705-710. PubMed PMID: 31505247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can dietary jujube (Ziziphus jujuba Mill.) fruit extract alter cutaneous mucosal immunity, immune related genes expression in skin and growth performance of common carp (Cyprinus carpio)? AU - Hoseinifar,Seyed Hossein, AU - Khodadadian Zou,Hassan, AU - Van Doan,Hien, AU - Harikrishnan,Ramasamy, AU - Yousefi,Morteza, AU - Paknejad,Hamed, AU - Ahmadifar,Ehsan, Y1 - 2019/09/07/ PY - 2019/05/24/received PY - 2019/08/31/revised PY - 2019/09/05/accepted PY - 2019/9/11/pubmed PY - 2020/2/8/medline PY - 2019/9/11/entrez KW - Cyprinus carpio KW - Gene expression KW - Immune response KW - Mucus KW - Skin KW - Ziziphus jujube SP - 705 EP - 710 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 94 N2 - The present study investigates the effect of dietary Ziziphus jujube fruit extract [ZJFE] on skin mucus non-specific immune parameters as well as mRNA levels of immune related gene in the skin of common carp fingerlings. An eight-week feeding trial was performed using different levels of dietary ZJFE (0, 0.25, 0.5 and 1%). At the end of the trial skin mucus immune parameters (total Ig, lysozyme and protease activity), cytokines genes (il1b, il8, il10 and tnf-alpha) expression in skin and growth performance were studied. The result showed highest and lowest skin mucus total Ig were observed in fish fed diet containing 0.5% ZJFE and control group, respectively (P < 0.05). There were no significant difference among treatments regarding skin mucus lysozyme activity (P >0.05). It should be noted that, feeding on 0.5 and 1% ZJFE significantly increased skin mucus protease activity (P <0.05). Likewise, gene expression studies in skin showed significant increase of il1b expression in fish fed 0.5% ZJFE compared other treatments (P <0.05). Also, il8 gene was noticeably up-regulated in 0.5 and 1% treatments compared to the control group (P <0.05). While there were no significant difference between 0.25% JFE treatment and control in case of relative il10 gene expression (P >0.05), feeding on diets containing 0.5% or 1% ZJFE significantly down-regulated il10 gene (P <0.05). Our study indicated that relative expression of tnf-alpha gene significantly increased in treated groups (P <0.05). Also, feeding on ZJFE supplemented diet improved growth performance parameters. Overall, this experiment demonstrated the potentially useful effects of ZJFE on skin mucosal immunity and performance of common carp fingerlings. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/31505247/Can_dietary_jujube__Ziziphus_jujuba_Mill___fruit_extract_alter_cutaneous_mucosal_immunity_immune_related_genes_expression_in_skin_and_growth_performance_of_common_carp__Cyprinus_carpio_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(19)30893-9 DB - PRIME DP - Unbound Medicine ER -