Tags

Type your tag names separated by a space and hit enter

Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction.
Clin Infect Dis 2019; 69(Supplement_2):S133-S139CI

Abstract

BACKGROUND

Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010-2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016.

METHODS

Cerebrospinal fluid (CSF) specimens from children <5 years old with suspected meningitis were tested to detect vaccine-preventable bacterial pathogens. Confirmatory identification and serotyping/grouping of Streptococcus pneumoniae, N. meningitidis, and H. influenzae were done. Antimicrobial susceptibility testing and whole genome sequencing were performed on S. pneumoniae isolates.

RESULTS

The surveillance included 2580 patients with suspected meningitis, of whom 80.8% (2085/2580) had CSF collected. Bacterial meningitis was confirmed in 273 patients: 48% (131/273) was N. meningitidis, 45% (123/273) S. pneumoniae, and 7% (19/273) H. influenzae. Streptococcus pneumoniae meningitis decreased from 34 in 2014, to 16 in 2016. PCV13 serotypes made up 88% (7/8) of S. pneumoniae meningitis prevaccination and 20% (5/20) postvaccination. Neisseria meningitidis serogroup C (NmC) was responsible for 59% (10/17) of serogrouped N. meningitidis meningitis. Hib caused 67% (2/3) of the H. influenzae meningitis isolates serotyped. Penicillin resistance was found in 16% (4/25) of S. pneumoniae isolates. Sequence type 217 was the most common lineage among S. pneumoniae isolates.

CONCLUSIONS

Neisseria meningitidis and S. pneumoniae remain important causes of meningitis in children in Niger. The decline in the numbers of S. pneumoniae meningitis post-PCV13 is encouraging and should continue to be monitored. NmC is the predominant serogroup causing N. meningitidis meningitis.

Authors+Show Affiliations

Laboratoire Hopital National de Niamey, Niger.World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom.Laboratoire Hopital National de Niamey, Niger.World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom.WHO Country Office, Niamey, Niger.WHO Country Office, Niamey, Niger.World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom.World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom.WHO Country Office, Niamey, Niger.WHO Regional Office for Africa, Brazzaville, Republic of Congo.WHO Regional Office for Africa, Brazzaville, Republic of Congo.WHO Intercountry Support Team for West Africa, Ouagadougou, Burkina Faso.World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom.World Health Organization (WHO) Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, United Kingdom. Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31505636

Citation

Kourna Hama, Mamadou, et al. "Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria Meningitidis Serogroup C, and a Decrease in Streptococcus Pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 69, no. Supplement_2, 2019, pp. S133-S139.
Kourna Hama M, Khan D, Laouali B, et al. Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction. Clin Infect Dis. 2019;69(Supplement_2):S133-S139.
Kourna Hama, M., Khan, D., Laouali, B., Okoi, C., Yam, A., Haladou, M., ... Antonio, M. (2019). Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 69(Supplement_2), pp. S133-S139. doi:10.1093/cid/ciz598.
Kourna Hama M, et al. Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria Meningitidis Serogroup C, and a Decrease in Streptococcus Pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction. Clin Infect Dis. 2019 Sep 5;69(Supplement_2):S133-S139. PubMed PMID: 31505636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction. AU - Kourna Hama,Mamadou, AU - Khan,Dam, AU - Laouali,Boubou, AU - Okoi,Catherine, AU - Yam,Abdoulaye, AU - Haladou,Moussa, AU - Worwui,Archibald, AU - Ndow,Peter Sylvanus, AU - Nse Obama,Ricardo, AU - Mwenda,Jason M, AU - Biey,Joseph, AU - Ntsama,Bernard, AU - Kwambana-Adams,Brenda A, AU - Antonio,Martin, PY - 2019/9/11/entrez PY - 2019/9/11/pubmed PY - 2019/9/11/medline KW - N. meningitidis KW - S. pneumoniae KW - Niger KW - cerebrospinal fluid KW - meningitis SP - S133 EP - S139 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 69 IS - Supplement_2 N2 - BACKGROUND: Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010-2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016. METHODS: Cerebrospinal fluid (CSF) specimens from children <5 years old with suspected meningitis were tested to detect vaccine-preventable bacterial pathogens. Confirmatory identification and serotyping/grouping of Streptococcus pneumoniae, N. meningitidis, and H. influenzae were done. Antimicrobial susceptibility testing and whole genome sequencing were performed on S. pneumoniae isolates. RESULTS: The surveillance included 2580 patients with suspected meningitis, of whom 80.8% (2085/2580) had CSF collected. Bacterial meningitis was confirmed in 273 patients: 48% (131/273) was N. meningitidis, 45% (123/273) S. pneumoniae, and 7% (19/273) H. influenzae. Streptococcus pneumoniae meningitis decreased from 34 in 2014, to 16 in 2016. PCV13 serotypes made up 88% (7/8) of S. pneumoniae meningitis prevaccination and 20% (5/20) postvaccination. Neisseria meningitidis serogroup C (NmC) was responsible for 59% (10/17) of serogrouped N. meningitidis meningitis. Hib caused 67% (2/3) of the H. influenzae meningitis isolates serotyped. Penicillin resistance was found in 16% (4/25) of S. pneumoniae isolates. Sequence type 217 was the most common lineage among S. pneumoniae isolates. CONCLUSIONS: Neisseria meningitidis and S. pneumoniae remain important causes of meningitis in children in Niger. The decline in the numbers of S. pneumoniae meningitis post-PCV13 is encouraging and should continue to be monitored. NmC is the predominant serogroup causing N. meningitidis meningitis. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/31505636/Pediatric_Bacterial_Meningitis_Surveillance_in_Niger:_Increased_Importance_of_Neisseria_meningitidis_Serogroup_C,_and_a_Decrease_in_Streptococcus_pneumoniae_Following_13-Valent_Pneumococcal_Conjugate_Vaccine_Introduction L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/ciz598 DB - PRIME DP - Unbound Medicine ER -