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Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018.
Helicobacter 2019; 24(6):e12660H

Abstract

BACKGROUND

Antimicrobial resistance of Helicobacter pylori (H pylori) affects the efficacy of eradication therapy. The aim of this study was to estimate the prevalence of primary and secondary resistance of H pylori isolates to antibiotics in Korea.

METHODS

The present study was performed from 2003 to 2018. Primary resistance was evaluated in 591 patients without any history of eradication and secondary resistance in 149 patients from whom Helicobacter pylori was cultured after failure of eradication. A minimal inhibitory concentration test was performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin using the agar dilution method.

RESULTS

An increase in the primary resistance rate was found in clarithromycin (P < .001), metronidazole (P < .001), and both levofloxacin (P < .001) during the study period. The primary resistance rates of amoxicillin and tetracycline were low and stable during the study period. The secondary resistance rate significantly increased in metronidazole and levofloxacin (P = .022 and .039, respectively).

CONCLUSIONS

The primary and secondary resistance rates of clarithromycin, metronidazole, and levofloxacin for Helicobacter pylori in Korea were high and increased over time. However, the primary and secondary resistance rates of amoxicillin and tetracycline were low and stable over time. These results will help in selecting effective eradication regimens of H pylori in Korea in the future.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, South Korea. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, South Korea. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, South Korea.Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, South Korea. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31507036

Citation

Lee, Ju Yup, et al. "Primary and Secondary Antibiotic Resistance of Helicobacter Pylori in Korea From 2003 to 2018." Helicobacter, vol. 24, no. 6, 2019, pp. e12660.
Lee JY, Kim N, Nam RH, et al. Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018. Helicobacter. 2019;24(6):e12660.
Lee, J. Y., Kim, N., Nam, R. H., In Choi, S., Lee, J. W., & Lee, D. H. (2019). Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018. Helicobacter, 24(6), pp. e12660. doi:10.1111/hel.12660.
Lee JY, et al. Primary and Secondary Antibiotic Resistance of Helicobacter Pylori in Korea From 2003 to 2018. Helicobacter. 2019;24(6):e12660. PubMed PMID: 31507036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018. AU - Lee,Ju Yup, AU - Kim,Nayoung, AU - Nam,Ryoung Hee, AU - In Choi,Soo, AU - Lee,Jung Won, AU - Lee,Dong Ho, Y1 - 2019/09/11/ PY - 2019/06/12/received PY - 2019/08/07/revised PY - 2019/08/08/accepted PY - 2019/9/12/pubmed PY - 2019/9/12/medline PY - 2019/9/12/entrez KW - Helicobacter pylori KW - antibiotics KW - prevalence KW - resistance SP - e12660 EP - e12660 JF - Helicobacter JO - Helicobacter VL - 24 IS - 6 N2 - BACKGROUND: Antimicrobial resistance of Helicobacter pylori (H pylori) affects the efficacy of eradication therapy. The aim of this study was to estimate the prevalence of primary and secondary resistance of H pylori isolates to antibiotics in Korea. METHODS: The present study was performed from 2003 to 2018. Primary resistance was evaluated in 591 patients without any history of eradication and secondary resistance in 149 patients from whom Helicobacter pylori was cultured after failure of eradication. A minimal inhibitory concentration test was performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin using the agar dilution method. RESULTS: An increase in the primary resistance rate was found in clarithromycin (P < .001), metronidazole (P < .001), and both levofloxacin (P < .001) during the study period. The primary resistance rates of amoxicillin and tetracycline were low and stable during the study period. The secondary resistance rate significantly increased in metronidazole and levofloxacin (P = .022 and .039, respectively). CONCLUSIONS: The primary and secondary resistance rates of clarithromycin, metronidazole, and levofloxacin for Helicobacter pylori in Korea were high and increased over time. However, the primary and secondary resistance rates of amoxicillin and tetracycline were low and stable over time. These results will help in selecting effective eradication regimens of H pylori in Korea in the future. SN - 1523-5378 UR - https://www.unboundmedicine.com/medline/citation/31507036/Primary_and_secondary_antibiotic_resistance_of_Helicobacter_pylori_in_Korea_from_2003_to_2018 L2 - https://doi.org/10.1111/hel.12660 DB - PRIME DP - Unbound Medicine ER -