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Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects.
Exp Clin Endocrinol. 1988 Aug; 91(3):365-8.EC

Abstract

The cause of serum T4 elevation after iopanoic acid administration was searched in euthyroid subjects. 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administration (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but no TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TRH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and not that of inhibited T4 conversion rate.

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Authors+Show Affiliations

Szabolcs I
Postgraduate Medical School, I. Department of Internal Medicine, Budapest, Hungary.
Kovács Z
No affiliation info available
Góth M
No affiliation info available
Szilágyi G
No affiliation info available

MeSH

AdultFemaleHumansIopanoic AcidMaleThyroid GlandThyrotropin-Releasing HormoneThyroxineTriiodothyronineTriiodothyronine, Reverse

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3150834

Citation

Szabolcs, I, et al. "Effect of Simultaneously Administered Iopanoic Acid and Thyrotropin Releasing Hormone (TRH) On Thyroid Hormone Metabolism in Euthyroid Subjects." Experimental and Clinical Endocrinology, vol. 91, no. 3, 1988, pp. 365-8.
Szabolcs I, Kovács Z, Góth M, et al. Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects. Exp Clin Endocrinol. 1988;91(3):365-8.
Szabolcs, I., Kovács, Z., Góth, M., & Szilágyi, G. (1988). Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects. Experimental and Clinical Endocrinology, 91(3), 365-8.
Szabolcs I, et al. Effect of Simultaneously Administered Iopanoic Acid and Thyrotropin Releasing Hormone (TRH) On Thyroid Hormone Metabolism in Euthyroid Subjects. Exp Clin Endocrinol. 1988;91(3):365-8. PubMed PMID: 3150834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of simultaneously administered iopanoic acid and thyrotropin releasing hormone (TRH) on thyroid hormone metabolism in euthyroid subjects. AU - Szabolcs,I, AU - Kovács,Z, AU - Góth,M, AU - Szilágyi,G, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 365 EP - 8 JF - Experimental and clinical endocrinology JO - Exp Clin Endocrinol VL - 91 IS - 3 N2 - The cause of serum T4 elevation after iopanoic acid administration was searched in euthyroid subjects. 3 gr iopanoic acid was given per os to 9 healthy volunteers (group I), in other 5 volunteers a TRH test was performed prior to iopanoic acid administration (group II). In group I TSH, T4, FT4I and rT3 levels increased, in group II T3 and FT3I decreased, but no TSH, T4, FT4I increase was seen, obviously, because of the exhaustion of pituitary TSH content by TRH. On the ground of the findings T4 elevation caused by iopanoic acid is predominantly consequence of TSH release and not that of inhibited T4 conversion rate. SN - 0232-7384 UR - https://www.unboundmedicine.com/medline/citation/3150834/Effect_of_simultaneously_administered_iopanoic_acid_and_thyrotropin_releasing_hormone__TRH__on_thyroid_hormone_metabolism_in_euthyroid_subjects_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1210771 DB - PRIME DP - Unbound Medicine ER -