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Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank.
Commun Biol 2019; 2:332CB

Abstract

Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of genetically predicted insulin in myocardial infarction (MI) (14,442 cases, 77% men), angina (21,939 cases, 65% men) and heart failure (5537 cases, 71% men). Genetically predicted insulin was associated with MI (odds ratio (OR) 4.27 per pmol/L higher insulin, 95% confidence interval (CI) 1.60 to 11.3) and angina (OR 2.93, 1.27 to 6.73) in men, but not women (MI OR 0.80, 95% CI 0.23 to 2.84, angina OR 1.10, 95% CI 0.38 to 3.18). Patterns were similar for insulin resistance and heart failure. Mitigating the effects of insulin might address sexual disparities in health.

Authors+Show Affiliations

1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. 2City University of New York, School of Public Health and Health Policy, New York, NY USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31508506

Citation

Zhao, Jie V., et al. "Sex-specific Mendelian Randomization Study of Genetically Predicted Insulin and Cardiovascular Events in the UK Biobank." Communications Biology, vol. 2, 2019, p. 332.
Zhao JV, Luo S, Schooling CM. Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank. Commun Biol. 2019;2:332.
Zhao, J. V., Luo, S., & Schooling, C. M. (2019). Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank. Communications Biology, 2, p. 332. doi:10.1038/s42003-019-0579-z.
Zhao JV, Luo S, Schooling CM. Sex-specific Mendelian Randomization Study of Genetically Predicted Insulin and Cardiovascular Events in the UK Biobank. Commun Biol. 2019;2:332. PubMed PMID: 31508506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank. AU - Zhao,Jie V, AU - Luo,Shan, AU - Schooling,C Mary, Y1 - 2019/09/05/ PY - 2019/04/17/received PY - 2019/08/08/accepted PY - 2019/9/12/entrez PY - 2019/9/12/pubmed PY - 2019/9/12/medline KW - Genetic association study KW - Risk factors KW - Statistical methods SP - 332 EP - 332 JF - Communications biology JO - Commun Biol VL - 2 N2 - Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of genetically predicted insulin in myocardial infarction (MI) (14,442 cases, 77% men), angina (21,939 cases, 65% men) and heart failure (5537 cases, 71% men). Genetically predicted insulin was associated with MI (odds ratio (OR) 4.27 per pmol/L higher insulin, 95% confidence interval (CI) 1.60 to 11.3) and angina (OR 2.93, 1.27 to 6.73) in men, but not women (MI OR 0.80, 95% CI 0.23 to 2.84, angina OR 1.10, 95% CI 0.38 to 3.18). Patterns were similar for insulin resistance and heart failure. Mitigating the effects of insulin might address sexual disparities in health. SN - 2399-3642 UR - https://www.unboundmedicine.com/medline/citation/31508506/Sex-specific_Mendelian_randomization_study_of_genetically_predicted_insulin_and_cardiovascular_events_in_the_UK_Biobank L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31508506/ DB - PRIME DP - Unbound Medicine ER -