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Clinical approach to the patient with Brugada Syndrome. Risk stratification and optimal management.

Abstract

The Brugada syndrome is an inherited cardiac ion channel disorder associated with increased risk of ventricular arrhythmias and mortality. Diagnosis is based on a characteristic electrocardiographic (ECG) pattern of coved type ST-segment elevation >2 mm followed by a negative T-wave in ≥1 of the right precordial leads V1 to V3. Since the first description of Brugada syndrome, the definition of disease and underlying pathophysiological mechanisms have been significantly improved in recent years. Also, significant progress has been made in the field of genetic testing in these patients. Still, there are several open questions regarding the management and outcome of these patients. There is more information about patients who would need an implantable cardiac defibrillator for the primary prevention of sudden cardiac death (that is, those with spontaneous Type I Brugada ECG pattern and arrhythmia-related syncope), but currently published data concerning asymptomatic patients with Brugada ECG pattern and other less-well defined presentations are conflicting. Whereas the role of cardiac defibrillator in patients with Brugada syndrome is clear, optimal use of catheter ablation and antiarrhythmic drug therapy needs to be further investigated. In this review, we summarize current evidence and contemporary management of patients with Brugada syndrome.

Authors+Show Affiliations

Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia - marinkovicm86@gmail.com.Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia. School of Medicine, University of Belgrade, Belgrade, Serbia.Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia. School of Medicine, University of Belgrade, Belgrade, Serbia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31508925

Citation

Marinković, Milan M., et al. "Clinical Approach to the Patient With Brugada Syndrome. Risk Stratification and Optimal Management." Panminerva Medica, 2019.
Marinković MM, Mujović NM, Potpara TS. Clinical approach to the patient with Brugada Syndrome. Risk stratification and optimal management. Panminerva Med. 2019.
Marinković, M. M., Mujović, N. M., & Potpara, T. S. (2019). Clinical approach to the patient with Brugada Syndrome. Risk stratification and optimal management. Panminerva Medica, doi:10.23736/S0031-0808.19.03736-4.
Marinković MM, Mujović NM, Potpara TS. Clinical Approach to the Patient With Brugada Syndrome. Risk Stratification and Optimal Management. Panminerva Med. 2019 Sep 6; PubMed PMID: 31508925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical approach to the patient with Brugada Syndrome. Risk stratification and optimal management. AU - Marinković,Milan M, AU - Mujović,Nebojša M, AU - Potpara,Tatjana S, Y1 - 2019/09/06/ PY - 2019/9/12/entrez JF - Panminerva medica JO - Panminerva Med N2 - The Brugada syndrome is an inherited cardiac ion channel disorder associated with increased risk of ventricular arrhythmias and mortality. Diagnosis is based on a characteristic electrocardiographic (ECG) pattern of coved type ST-segment elevation >2 mm followed by a negative T-wave in ≥1 of the right precordial leads V1 to V3. Since the first description of Brugada syndrome, the definition of disease and underlying pathophysiological mechanisms have been significantly improved in recent years. Also, significant progress has been made in the field of genetic testing in these patients. Still, there are several open questions regarding the management and outcome of these patients. There is more information about patients who would need an implantable cardiac defibrillator for the primary prevention of sudden cardiac death (that is, those with spontaneous Type I Brugada ECG pattern and arrhythmia-related syncope), but currently published data concerning asymptomatic patients with Brugada ECG pattern and other less-well defined presentations are conflicting. Whereas the role of cardiac defibrillator in patients with Brugada syndrome is clear, optimal use of catheter ablation and antiarrhythmic drug therapy needs to be further investigated. In this review, we summarize current evidence and contemporary management of patients with Brugada syndrome. SN - 1827-1898 UR - https://www.unboundmedicine.com/medline/citation/31508925/Clinical_approach_to_the_patient_with_Brugada_Syndrome._Risk_stratification_and_optimal_management L2 - https://www.minervamedica.it/index2.t?show=R41Y9999N00A19090601 DB - PRIME DP - Unbound Medicine ER -