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Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial.
Nutrients. 2019 Sep 10; 11(9)N

Abstract

Partially hydrolyzed guar gum (PHGG) is a water-soluble dietary fiber and is used in solid and liquid food to regulate gut function. The aim of this study was to investigate effects of PHGG on bowel movements (stool form and frequency), plasma bile acids, quality of life, and gut microbiota of healthy volunteers with a tendency toward diarrhea, i.e., irritable bowel syndrome diarrhea (IBS-D)-like symptoms. A randomized, double-blind, placebo-controlled, and parallel trial was performed on 44 healthy volunteers (22 males, 22 females, 41.9 ± 6.3 years old (average ± SD)) with minimum 7 bowel movements every week, wherein above 50% of their stool was between the Bristol stool scale (BSS) value of 5 and 6. Intake of the PHGG for 3 months significantly improved stool form, evaluated using BSS, and had no effects on stool frequency. BSS was significantly normalized in the group consuming the PHGG compared with the placebo. Comprehensive fecal microbiome analysis by the 16S rRNA-sequence method detected significant changes in the ratio of some bacteria, such as an increase of Bifidobacterium (p < 0.05) in the PHGG group. Our results suggest that intake of PHGG improves human stool form via regulating intestinal microbiota.

Authors+Show Affiliations

Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan. zyasukawa@taiyokagaku.co.jp. Academic-Industrial Graduate School, Mie University, Tsu, Mie 514-8507, Japan. zyasukawa@taiyokagaku.co.jp.Laboratory of Animal Science, Department of Agricultural and Life Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan. r-inoue@kpu.ac.jp.Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan. mozeki@taiyokagaku.co.jp. Academic-Industrial Graduate School, Mie University, Tsu, Mie 514-8507, Japan. mozeki@taiyokagaku.co.jp.Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan. tohkubo@taiyokagaku.co.jp. Academic-Industrial Graduate School, Mie University, Tsu, Mie 514-8507, Japan. tohkubo@taiyokagaku.co.jp.Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. takatomo@koto.kpu-m.ac.jp.Gastroenterology, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki 300-0395, Japan. tmuandumin@gmail.com.Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. ynaito@koto.kpu-m.ac.jp.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31509971

Citation

Yasukawa, Zenta, et al. "Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum On Fecal Characteristics and Gut Microbiota: a Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial." Nutrients, vol. 11, no. 9, 2019.
Yasukawa Z, Inoue R, Ozeki M, et al. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial. Nutrients. 2019;11(9).
Yasukawa, Z., Inoue, R., Ozeki, M., Okubo, T., Takagi, T., Honda, A., & Naito, Y. (2019). Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial. Nutrients, 11(9). https://doi.org/10.3390/nu11092170
Yasukawa Z, et al. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum On Fecal Characteristics and Gut Microbiota: a Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial. Nutrients. 2019 Sep 10;11(9) PubMed PMID: 31509971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial. AU - Yasukawa,Zenta, AU - Inoue,Ryo, AU - Ozeki,Makoto, AU - Okubo,Tsutomu, AU - Takagi,Tomohisa, AU - Honda,Akira, AU - Naito,Yuji, Y1 - 2019/09/10/ PY - 2019/07/17/received PY - 2019/08/27/revised PY - 2019/09/02/accepted PY - 2019/9/13/entrez PY - 2019/9/13/pubmed PY - 2020/2/26/medline KW - 16S rRNA KW - Bristol stool scale KW - diarrhea KW - gut microbiota KW - partially hydrolyzed guar gum JF - Nutrients JO - Nutrients VL - 11 IS - 9 N2 - Partially hydrolyzed guar gum (PHGG) is a water-soluble dietary fiber and is used in solid and liquid food to regulate gut function. The aim of this study was to investigate effects of PHGG on bowel movements (stool form and frequency), plasma bile acids, quality of life, and gut microbiota of healthy volunteers with a tendency toward diarrhea, i.e., irritable bowel syndrome diarrhea (IBS-D)-like symptoms. A randomized, double-blind, placebo-controlled, and parallel trial was performed on 44 healthy volunteers (22 males, 22 females, 41.9 ± 6.3 years old (average ± SD)) with minimum 7 bowel movements every week, wherein above 50% of their stool was between the Bristol stool scale (BSS) value of 5 and 6. Intake of the PHGG for 3 months significantly improved stool form, evaluated using BSS, and had no effects on stool frequency. BSS was significantly normalized in the group consuming the PHGG compared with the placebo. Comprehensive fecal microbiome analysis by the 16S rRNA-sequence method detected significant changes in the ratio of some bacteria, such as an increase of Bifidobacterium (p < 0.05) in the PHGG group. Our results suggest that intake of PHGG improves human stool form via regulating intestinal microbiota. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31509971/Effect_of_Repeated_Consumption_of_Partially_Hydrolyzed_Guar_Gum_on_Fecal_Characteristics_and_Gut_Microbiota:_A_Randomized_Double_Blind_Placebo_Controlled_and_Parallel_Group_Clinical_Trial_ L2 - https://www.mdpi.com/resolver?pii=nu11092170 DB - PRIME DP - Unbound Medicine ER -