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Epidemiology and Diversity of Rickettsiales Bacteria in Humans and Animals in Jiangsu and Jiangxi provinces, China.
Sci Rep 2019; 9(1):13176SR

Abstract

Diseases caused by Rickettsiales bacteria are a global public health problem. To better understand the diversity and origins of Rickettsiales infection in humans and animals, we sampled 134 febrile patients, 173 rodents and 43 shrews, as well as 358 ticks, from two cities in Jiangsu and Jiangxi provinces, China. Our data revealed a relatively high prevalence of scrub typhus cases in both localities. In addition, both serological tests and genetic analysis identified three patients infected with Anaplasma bovis, Rickettsia monacensis, and Orientia tsutsugamushi bacteria. Molecular epidemiological investigation revealed the co-circulation of multiple species of Rickettsiales bacteria in small mammals and ticks in both provinces, potentially including novel bacterial species. In sum, these data demonstrate the ongoing importance of Rickettsiales infection in China and highlight the need for the regular surveillance of local arthropods, mammals and humans.

Authors+Show Affiliations

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.Yancheng Center for Disease Control and Prevention, Yancheng, Jiangsu province, China.Ganzhou Center for Disease Control and Prevention, Ganzhou, Jiangxi province, China.Yancheng Center for Disease Control and Prevention, Yancheng, Jiangsu province, China.Jiangxi Center for Disease Control and Prevention, Nanchang, Jiangxi province, China.Yancheng Center for Disease Control and Prevention, Yancheng, Jiangsu province, China.Ganzhou Center for Disease Control and Prevention, Ganzhou, Jiangxi province, China.State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China. Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia. Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China.State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China. zhangyongzhen@icdc.cn. Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China. zhangyongzhen@icdc.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31511528

Citation

Lu, Miao, et al. "Epidemiology and Diversity of Rickettsiales Bacteria in Humans and Animals in Jiangsu and Jiangxi Provinces, China." Scientific Reports, vol. 9, no. 1, 2019, p. 13176.
Lu M, Li F, Liao Y, et al. Epidemiology and Diversity of Rickettsiales Bacteria in Humans and Animals in Jiangsu and Jiangxi provinces, China. Sci Rep. 2019;9(1):13176.
Lu, M., Li, F., Liao, Y., Shen, J. J., Xu, J. M., Chen, Y. Z., ... Zhang, Y. Z. (2019). Epidemiology and Diversity of Rickettsiales Bacteria in Humans and Animals in Jiangsu and Jiangxi provinces, China. Scientific Reports, 9(1), p. 13176. doi:10.1038/s41598-019-49059-3.
Lu M, et al. Epidemiology and Diversity of Rickettsiales Bacteria in Humans and Animals in Jiangsu and Jiangxi Provinces, China. Sci Rep. 2019 Sep 11;9(1):13176. PubMed PMID: 31511528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology and Diversity of Rickettsiales Bacteria in Humans and Animals in Jiangsu and Jiangxi provinces, China. AU - Lu,Miao, AU - Li,Feng, AU - Liao,Yong, AU - Shen,Jin-Jin, AU - Xu,Jian-Min, AU - Chen,Yin-Zhong, AU - Li,Jian-Hua, AU - Holmes,Edward C, AU - Zhang,Yong-Zhen, Y1 - 2019/09/11/ PY - 2019/02/21/received PY - 2019/08/19/accepted PY - 2019/9/13/entrez PY - 2019/9/13/pubmed PY - 2019/9/13/medline SP - 13176 EP - 13176 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Diseases caused by Rickettsiales bacteria are a global public health problem. To better understand the diversity and origins of Rickettsiales infection in humans and animals, we sampled 134 febrile patients, 173 rodents and 43 shrews, as well as 358 ticks, from two cities in Jiangsu and Jiangxi provinces, China. Our data revealed a relatively high prevalence of scrub typhus cases in both localities. In addition, both serological tests and genetic analysis identified three patients infected with Anaplasma bovis, Rickettsia monacensis, and Orientia tsutsugamushi bacteria. Molecular epidemiological investigation revealed the co-circulation of multiple species of Rickettsiales bacteria in small mammals and ticks in both provinces, potentially including novel bacterial species. In sum, these data demonstrate the ongoing importance of Rickettsiales infection in China and highlight the need for the regular surveillance of local arthropods, mammals and humans. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31511528/Epidemiology_and_Diversity_of_Rickettsiales_Bacteria_in_Humans_and_Animals_in_Jiangsu_and_Jiangxi_provinces,_China L2 - http://dx.doi.org/10.1038/s41598-019-49059-3 DB - PRIME DP - Unbound Medicine ER -