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Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community.
Sci Rep 2019; 9(1):13156SR

Abstract

Prevalence estimates and evidence informing treatment targets for thyroid dysfunction largely come from studies of middle-aged adults. We conducted a cross-sectional analysis to determine the prevalence of thyroid dysfunction and risk factors for abnormal thyroid tests in participants aged ≥65 in the Atherosclerosis Risk in Communities (ARIC) study (N = 5,392). We measured serum concentrations of triiodothyronine (T3), free thyroxine (FT4), thyroid peroxidase antibody (Anti-TPO), and thyroid stimulating hormone (TSH). In this population (58% women, 22% black), 17% reported medication use for thyroid dysfunction. Among those not on treatment, the prevalence of overt and subclinical hypothyroidism was 0.82% and 6.06%, respectively. Overt and subclinical hyperthyroidism affected 0.26% and 0.78%, respectively. Multivariable adjusted TSH, FT4 and T3 levels were 25%, 1.3% and 3.9% lower in blacks compared to whites, respectively. Men were less likely to be anti-TPO positive compared to women (p < 0.001). Former and never smoking were associated with lower T3 and FT4 levels compared to current smoking. The prevalence of thyroid dysfunction in older adults is nearly 25%. Multiple illnesses can interact to contribute to declines in health. Additional attention to thyroid dysfunction and screening in this age group is recommended.

Authors+Show Affiliations

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA.Division of General Medicine, Beth Israel Deaconess Medical Centre/Harvard Medical School, Boston, MA, USA.Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. School of Medicine, National University of Ireland, Galway Campus, Ireland. National Institute for Preventive Cardiology, Galway, Ireland.Institute of Genetic Epidemiology, Medical Center - University of Freiburg and Faculty of Medicine, Freiburg, Germany. Renal Division, Department of Medicine IV, Medical Center - University of Freiburg Faculty of Medicine, Freiburg, Germany.Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Institute of Genetic Epidemiology, Medical Center - University of Freiburg and Faculty of Medicine, Freiburg, Germany.Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. eselvin@jhu.edu. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. eselvin@jhu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31511587

Citation

Diab, Nermin, et al. "Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community." Scientific Reports, vol. 9, no. 1, 2019, p. 13156.
Diab N, Daya NR, Juraschek SP, et al. Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community. Sci Rep. 2019;9(1):13156.
Diab, N., Daya, N. R., Juraschek, S. P., Martin, S. S., McEvoy, J. W., Schultheiβ, U. T., ... Selvin, E. (2019). Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community. Scientific Reports, 9(1), p. 13156. doi:10.1038/s41598-019-49540-z.
Diab N, et al. Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community. Sci Rep. 2019 Sep 11;9(1):13156. PubMed PMID: 31511587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community. AU - Diab,Nermin, AU - Daya,Natalie R, AU - Juraschek,Stephen P, AU - Martin,Seth S, AU - McEvoy,John W, AU - Schultheiβ,Ulla T, AU - Köttgen,Anna, AU - Selvin,Elizabeth, Y1 - 2019/09/11/ PY - 2019/06/17/received PY - 2019/08/27/accepted PY - 2019/9/13/entrez PY - 2019/9/13/pubmed PY - 2019/9/13/medline SP - 13156 EP - 13156 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Prevalence estimates and evidence informing treatment targets for thyroid dysfunction largely come from studies of middle-aged adults. We conducted a cross-sectional analysis to determine the prevalence of thyroid dysfunction and risk factors for abnormal thyroid tests in participants aged ≥65 in the Atherosclerosis Risk in Communities (ARIC) study (N = 5,392). We measured serum concentrations of triiodothyronine (T3), free thyroxine (FT4), thyroid peroxidase antibody (Anti-TPO), and thyroid stimulating hormone (TSH). In this population (58% women, 22% black), 17% reported medication use for thyroid dysfunction. Among those not on treatment, the prevalence of overt and subclinical hypothyroidism was 0.82% and 6.06%, respectively. Overt and subclinical hyperthyroidism affected 0.26% and 0.78%, respectively. Multivariable adjusted TSH, FT4 and T3 levels were 25%, 1.3% and 3.9% lower in blacks compared to whites, respectively. Men were less likely to be anti-TPO positive compared to women (p < 0.001). Former and never smoking were associated with lower T3 and FT4 levels compared to current smoking. The prevalence of thyroid dysfunction in older adults is nearly 25%. Multiple illnesses can interact to contribute to declines in health. Additional attention to thyroid dysfunction and screening in this age group is recommended. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31511587/Prevalence_and_Risk_Factors_of_Thyroid_Dysfunction_in_Older_Adults_in_the_Community L2 - http://dx.doi.org/10.1038/s41598-019-49540-z DB - PRIME DP - Unbound Medicine ER -