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Vitamin D deficiency in school-age Iranian children with attention-deficit/hyperactivity disorder (ADHD) symptoms: A critical comparison with healthy controls.
Child Neuropsychol 2019; :1-15CN

Abstract

The associations between serum vitamin D levels and the severity of attention-deficit/hyperactivity disorder (ADHD) symptoms were assessed among Iranian hospitalized children (50 ADHD cases and 50 healthy (non-ADHD) controls) during 2014-2015. Levels of ADHD severity and serum 25-hydroxyvitamin D (25OHD) were determined by the Conners' Parent Rating Scale (CPRS) test and an ELISA kit, respectively. The serum 25OHD concentrations of <10, 10-29, and >30 ng/mL were respectively considered as deficient (severe deficiency), insufficient (mild deficiency), and sufficient levels of vitamin D. The association of nutrient bioavailability with ADHD was evaluated by statistical and regression analyses.There was no significant difference in the mean of socio-demographic variables (e.g., gender, age, weight, BMI, daily intake of dairy products, and daily sunlight exposure) between ADHD and non-ADHD subjects. The mean serum 25OHD concentration (16.57 ± 9.09 ng/mL) was found to be significantly lower in ADHD children with more parathyroid hormone (PTH) levels as compared to controls (22.01 ± 12.67ng/mL). The sufficient 25OHD concentration was more predominant in the controls than the cases (p = 0.002). A severe deficiency of vitamin D was more found in children with ADHD (3.36 times). There was a negative and significant association between the participants' age and their serum 25OHD levels. Although 25OHD levels in boys were significantly more than those in girls, the reduction of serum 25OHD concentration among boys with ADHD was more severe compared to the patient girls(p = 0.014). The results support the importance of vitamins D role in ADHD patients through the regular monitoring of serum 25OHD levels.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran , Iran.Department of Pediatrics, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran , Iran.Maternal, Fetal and Neonatal Research Center, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran , Iran.Department of Pediatrics, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences , Tehran , Iran.Department of Psychiatry, Ziaeian Hospital, School of Medicine, Tehran University of Medical Sciences , Tehran , Iran.Health Management Research Center, Baqiyatallah University of Medical Sciences , Tehran , Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31514566

Citation

Fasihpour, Bahareh, et al. "Vitamin D Deficiency in School-age Iranian Children With Attention-deficit/hyperactivity Disorder (ADHD) Symptoms: a Critical Comparison With Healthy Controls." Child Neuropsychology : a Journal On Normal and Abnormal Development in Childhood and Adolescence, 2019, pp. 1-15.
Fasihpour B, Moayeri H, Shariat M, et al. Vitamin D deficiency in school-age Iranian children with attention-deficit/hyperactivity disorder (ADHD) symptoms: A critical comparison with healthy controls. Child Neuropsychol. 2019.
Fasihpour, B., Moayeri, H., Shariat, M., Keihanidoust, Z., Effatpanah, M., & Khedmat, L. (2019). Vitamin D deficiency in school-age Iranian children with attention-deficit/hyperactivity disorder (ADHD) symptoms: A critical comparison with healthy controls. Child Neuropsychology : a Journal On Normal and Abnormal Development in Childhood and Adolescence, pp. 1-15. doi:10.1080/09297049.2019.1665638.
Fasihpour B, et al. Vitamin D Deficiency in School-age Iranian Children With Attention-deficit/hyperactivity Disorder (ADHD) Symptoms: a Critical Comparison With Healthy Controls. Child Neuropsychol. 2019 Sep 13;1-15. PubMed PMID: 31514566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency in school-age Iranian children with attention-deficit/hyperactivity disorder (ADHD) symptoms: A critical comparison with healthy controls. AU - Fasihpour,Bahareh, AU - Moayeri,Heshmat, AU - Shariat,Mamak, AU - Keihanidoust,Zarrintaj, AU - Effatpanah,Mohammad, AU - Khedmat,Leila, Y1 - 2019/09/13/ PY - 2019/9/14/entrez KW - Attention-deficit/hyperactivity disorder (ADHD) KW - child development KW - diet KW - gender difference KW - vitamin D status SP - 1 EP - 15 JF - Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence JO - Child Neuropsychol N2 - The associations between serum vitamin D levels and the severity of attention-deficit/hyperactivity disorder (ADHD) symptoms were assessed among Iranian hospitalized children (50 ADHD cases and 50 healthy (non-ADHD) controls) during 2014-2015. Levels of ADHD severity and serum 25-hydroxyvitamin D (25OHD) were determined by the Conners' Parent Rating Scale (CPRS) test and an ELISA kit, respectively. The serum 25OHD concentrations of <10, 10-29, and >30 ng/mL were respectively considered as deficient (severe deficiency), insufficient (mild deficiency), and sufficient levels of vitamin D. The association of nutrient bioavailability with ADHD was evaluated by statistical and regression analyses.There was no significant difference in the mean of socio-demographic variables (e.g., gender, age, weight, BMI, daily intake of dairy products, and daily sunlight exposure) between ADHD and non-ADHD subjects. The mean serum 25OHD concentration (16.57 ± 9.09 ng/mL) was found to be significantly lower in ADHD children with more parathyroid hormone (PTH) levels as compared to controls (22.01 ± 12.67ng/mL). The sufficient 25OHD concentration was more predominant in the controls than the cases (p = 0.002). A severe deficiency of vitamin D was more found in children with ADHD (3.36 times). There was a negative and significant association between the participants' age and their serum 25OHD levels. Although 25OHD levels in boys were significantly more than those in girls, the reduction of serum 25OHD concentration among boys with ADHD was more severe compared to the patient girls(p = 0.014). The results support the importance of vitamins D role in ADHD patients through the regular monitoring of serum 25OHD levels. SN - 1744-4136 UR - https://www.unboundmedicine.com/medline/citation/31514566/Vitamin_D_deficiency_in_school-age_Iranian_children_with_attention-deficit/hyperactivity_disorder_(ADHD)_symptoms:_A_critical_comparison_with_healthy_controls L2 - http://www.tandfonline.com/doi/full/10.1080/09297049.2019.1665638 DB - PRIME DP - Unbound Medicine ER -