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Pure Autonomic Failure.
Mayo Clin Proc 2019; 94(10):2087-2098MC

Abstract

Pure autonomic failure (PAF) is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension. The disorder has also been known as Bradbury-Eggleston syndrome, named for the authors of the 1925 seminal description. Patients typically present in midlife or later with orthostatic hypotension or syncope. Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches. Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein. However, patients with PAF may progress into other synucleinopathies with central nervous system involvement.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address: coon.elizabeth@mayo.edu.Department of Neurology, Mayo Clinic, Rochester, MN.Department of Neurology, Mayo Clinic, Rochester, MN.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31515103

Citation

Coon, Elizabeth A., et al. "Pure Autonomic Failure." Mayo Clinic Proceedings, vol. 94, no. 10, 2019, pp. 2087-2098.
Coon EA, Singer W, Low PA. Pure Autonomic Failure. Mayo Clin Proc. 2019;94(10):2087-2098.
Coon, E. A., Singer, W., & Low, P. A. (2019). Pure Autonomic Failure. Mayo Clinic Proceedings, 94(10), pp. 2087-2098. doi:10.1016/j.mayocp.2019.03.009.
Coon EA, Singer W, Low PA. Pure Autonomic Failure. Mayo Clin Proc. 2019;94(10):2087-2098. PubMed PMID: 31515103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pure Autonomic Failure. AU - Coon,Elizabeth A, AU - Singer,Wolfgang, AU - Low,Phillip A, Y1 - 2019/09/09/ PY - 2018/06/28/received PY - 2019/03/06/revised PY - 2019/03/12/accepted PY - 2019/9/14/pubmed PY - 2019/9/14/medline PY - 2019/9/14/entrez SP - 2087 EP - 2098 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 94 IS - 10 N2 - Pure autonomic failure (PAF) is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension. The disorder has also been known as Bradbury-Eggleston syndrome, named for the authors of the 1925 seminal description. Patients typically present in midlife or later with orthostatic hypotension or syncope. Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches. Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein. However, patients with PAF may progress into other synucleinopathies with central nervous system involvement. SN - 1942-5546 UR - https://www.unboundmedicine.com/medline/citation/31515103/Pure_Autonomic_Failure L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(19)30265-4 DB - PRIME DP - Unbound Medicine ER -