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Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study.
Int J Mol Cell Med 2018; 7(4):226-233IJ

Abstract

Computed tomography (CT) is one of the most important diagnostic X-ray procedures which plays an important role in increasing the patient dose values. The purpose of this clinical study was to evaluate the efficacy of vitamins E and C in lowering down the level of DNA double strand break (DSB) caused by CT scan. Sixty patients for abdomen/pelvic enhanced CT scan were randomly assigned to placebo (control), vitamin C, and vitamin E groups. The patient blood samples were taken before and immediately after the CT scan. Counting the number of DSB was performed using γ-H2AX method as a sensitive biomarker. Immediately after the CT scan, the mean number of DSBs/cell increased in all three groups of control (131%, P<0.001), vitamin C (103%, P <0.001), and vitamin E (66%, P<0.001) compared to their mean before the CT scan. Furthermore, the results showed that vitamin E decreased the mean number of DSBs/cell by 22% in comparison with the control group (P =0.023), whereas vitamin C had no significant effect on reducing the DSB (<3%, P =0.741). It is concluded that the administration of vitamin E one hour before the CT scan, significantly decreases DSB levels.

Authors+Show Affiliations

Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Medical laboratory, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Radiology, Kashan University of Medical Sciences, Kashan, Iran.Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.Department of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, Iran.Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31516882

Citation

Jafarpour, Seyed Masoud, et al. "Evaluation of Ameliorative Potential of Vitamins E and C On DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): a Clinical Study." International Journal of Molecular and Cellular Medicine, vol. 7, no. 4, 2018, pp. 226-233.
Jafarpour SM, Salimian M, Mohseni M, et al. Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study. Int J Mol Cell Med. 2018;7(4):226-233.
Jafarpour, S. M., Salimian, M., Mohseni, M., Talari, H. R., Aliasgharzadeh, A., Farhood, B., ... Safari, H. (2018). Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study. International Journal of Molecular and Cellular Medicine, 7(4), pp. 226-233. doi:10.22088/IJMCM.BUMS.7.4.226.
Jafarpour SM, et al. Evaluation of Ameliorative Potential of Vitamins E and C On DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): a Clinical Study. Int J Mol Cell Med. 2018;7(4):226-233. PubMed PMID: 31516882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study. AU - Jafarpour,Seyed Masoud, AU - Salimian,Morteza, AU - Mohseni,Mehran, AU - Talari,Hamid Reza, AU - Aliasgharzadeh,Akbar, AU - Farhood,Bagher, AU - Moradi,Habiballah, AU - Safari,Hossein, Y1 - 2019/03/04/ PY - 2018/10/20/received PY - 2019/02/24/accepted PY - 2019/9/14/entrez PY - 2019/9/14/pubmed PY - 2019/9/14/medline KW - Computed tomography (CT) KW - DNA double strand break (DSB) KW - Vitamin C KW - Vitamin E SP - 226 EP - 233 JF - International journal of molecular and cellular medicine JO - Int J Mol Cell Med VL - 7 IS - 4 N2 - Computed tomography (CT) is one of the most important diagnostic X-ray procedures which plays an important role in increasing the patient dose values. The purpose of this clinical study was to evaluate the efficacy of vitamins E and C in lowering down the level of DNA double strand break (DSB) caused by CT scan. Sixty patients for abdomen/pelvic enhanced CT scan were randomly assigned to placebo (control), vitamin C, and vitamin E groups. The patient blood samples were taken before and immediately after the CT scan. Counting the number of DSB was performed using γ-H2AX method as a sensitive biomarker. Immediately after the CT scan, the mean number of DSBs/cell increased in all three groups of control (131%, P<0.001), vitamin C (103%, P <0.001), and vitamin E (66%, P<0.001) compared to their mean before the CT scan. Furthermore, the results showed that vitamin E decreased the mean number of DSBs/cell by 22% in comparison with the control group (P =0.023), whereas vitamin C had no significant effect on reducing the DSB (<3%, P =0.741). It is concluded that the administration of vitamin E one hour before the CT scan, significantly decreases DSB levels. SN - 2251-9637 UR - https://www.unboundmedicine.com/medline/citation/31516882/Evaluation_of_Ameliorative_Potential_of_Vitamins_E_and_C_on_DNA_Double_Strand_Break_(DSB)_in_Patients_Undergoing_Computed_Tomography_(CT):_A_Clinical_Study DB - PRIME DP - Unbound Medicine ER -