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Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care.
Int J Pharm X. 2019 Dec; 1:100012.IJ

Abstract

The aim of this study was to design and evaluate muco-adhesive orally disintegrating tablets manufactured by microwave irradiation and containing polysaccharide. We prepared orally disintegrating tea tablets (ODTTs) containing a 1 w/w% mass fraction of one of five polysaccharides (gum arabic, carrageenan, guar gum, tamarind gum, or pectin) and evaluated the swelling degree, tablet hardness, friability, disintegration time, and adhesive properties. All tablets had a swelling degree of about 1 mm, a hardness of over 13 N, and a friability degree of <1%. Tablets containing gum arabic and tamarind gum had disintegration times of 30 s or less and satisfied requirements as orally disintegrating tablets. This could be attributed to their high void contents, which allowed for water penetration. The adhesive properties and particle retention ratios were highest in ODTTs containing tamarind gum, which was thought to be caused by the rapid disintegration and high viscosity of the tamarind gum itself. When we investigated changing the mass fraction of tamarind gum, we found 1 w/w% was most suitable for rapid disintegration and high adhesiveness. The ODTTs containing 1 w/w% tamarind gum showed significant growth inhibition towards Streptococcus mutans. Therefore, microwave irradiation technology and addition of tamarind gum could be used to manufacture muco-adhesive orally disintegrating tablets for oral care.

Authors+Show Affiliations

Laboratory of Pharmaceutical Engineering and Drug Delivery Science, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.Laboratory of Pharmaceutical Engineering and Drug Delivery Science, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.Laboratory of Pharmaceutical Engineering and Drug Delivery Science, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.Laboratory of Pharmaceutical Engineering and Drug Delivery Science, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.Laboratory of Pharmaceutical Engineering and Drug Delivery Science, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31517277

Citation

Kiniwa, Rika, et al. "Development of Muco-adhesive Orally Disintegrating Tablets Containing Tamarind Gum-coated Tea Powders for Oral Care." International Journal of Pharmaceutics: X, vol. 1, 2019, p. 100012.
Kiniwa R, Miyake M, Kimura SI, et al. Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care. Int J Pharm X. 2019;1:100012.
Kiniwa, R., Miyake, M., Kimura, S. I., Itai, S., Kondo, H., & Iwao, Y. (2019). Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care. International Journal of Pharmaceutics: X, 1, 100012. https://doi.org/10.1016/j.ijpx.2019.100012
Kiniwa R, et al. Development of Muco-adhesive Orally Disintegrating Tablets Containing Tamarind Gum-coated Tea Powders for Oral Care. Int J Pharm X. 2019;1:100012. PubMed PMID: 31517277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of muco-adhesive orally disintegrating tablets containing tamarind gum-coated tea powders for oral care. AU - Kiniwa,Rika, AU - Miyake,Masaki, AU - Kimura,Shin-Ichiro, AU - Itai,Shigeru, AU - Kondo,Hiromu, AU - Iwao,Yasunori, Y1 - 2019/04/04/ PY - 2018/12/18/received PY - 2019/03/07/revised PY - 2019/04/03/accepted PY - 2019/9/14/entrez PY - 2019/9/14/pubmed PY - 2019/9/14/medline KW - Adhesive property KW - ECG, Epicatechin gallate KW - EGC, Epigallocatechin KW - EGCG, Epigallocatechin gallate KW - GCG, Gallocatechin gallate KW - Microwave KW - ODTTs, Orally disintegrating tea tablets KW - ODTs, Orally disintegrating tablets KW - Oral care KW - Orally disintegrating tablet KW - SEM, Scanning electron microscope KW - Tamarind gum KW - Tea powder SP - 100012 EP - 100012 JF - International journal of pharmaceutics: X JO - Int J Pharm X VL - 1 N2 - The aim of this study was to design and evaluate muco-adhesive orally disintegrating tablets manufactured by microwave irradiation and containing polysaccharide. We prepared orally disintegrating tea tablets (ODTTs) containing a 1 w/w% mass fraction of one of five polysaccharides (gum arabic, carrageenan, guar gum, tamarind gum, or pectin) and evaluated the swelling degree, tablet hardness, friability, disintegration time, and adhesive properties. All tablets had a swelling degree of about 1 mm, a hardness of over 13 N, and a friability degree of <1%. Tablets containing gum arabic and tamarind gum had disintegration times of 30 s or less and satisfied requirements as orally disintegrating tablets. This could be attributed to their high void contents, which allowed for water penetration. The adhesive properties and particle retention ratios were highest in ODTTs containing tamarind gum, which was thought to be caused by the rapid disintegration and high viscosity of the tamarind gum itself. When we investigated changing the mass fraction of tamarind gum, we found 1 w/w% was most suitable for rapid disintegration and high adhesiveness. The ODTTs containing 1 w/w% tamarind gum showed significant growth inhibition towards Streptococcus mutans. Therefore, microwave irradiation technology and addition of tamarind gum could be used to manufacture muco-adhesive orally disintegrating tablets for oral care. SN - 2590-1567 UR - https://www.unboundmedicine.com/medline/citation/31517277/Development_of_muco_adhesive_orally_disintegrating_tablets_containing_tamarind_gum_coated_tea_powders_for_oral_care_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2590-1567(19)30026-X DB - PRIME DP - Unbound Medicine ER -
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