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Oropharyngeal and genital gonorrhoea infections among women and heterosexual men reporting sexual contact with partners with gonorrhoea: implication for oropharyngeal testing of heterosexual gonorrhoea contacts.

Abstract

BACKGROUND

There have been very limited studies of oropharyngeal gonorrhoea in heterosexuals. Routine screening of oropharyngeal gonorrhoea is not recommended in heterosexual contacts of gonorrhoea. The study aimed to examine oropharyngeal gonorrhoea positivity among heterosexuals reporting contact with a partner with gonorrhoea.

METHODS

At the Melbourne Sexual Health Centre (MSHC), all heterosexual individuals reporting contact with sexual partners with gonorrhoea are tested for genital gonorrhoea. In May-2017, MSHC also included screening for oropharyngeal gonorrhoea in heterosexual contacts of gonorrhoea. All contacts of gonorrhoea among women and heterosexual men between May-2017 and November-2018 were reviewed. Site-specific gonorrhoea positivity was also calculated.

RESULTS

191 gonorrhoea contacts (102 heterosexual men and 89 women) were reviewed. The median age was 28 [IQR=24-33] years. The gonorrhoea positivity in males was significantly higher at the oropharynx compared to urethra (18% [95% CI: 11% to 26%] versus 2% [0% to 7%]; p<0.001); and higher at the oropharynx compared to cervico-vaginal site in women (46% [35% to 57%] versus 36% [26% to 47%]; p=0.056). Of the 100 men who did not have genital gonorrhoea, 17 (18% [10% to 26%]) tested positive at the oropharynx. Of the 55 women who did not have genital gonorrhoea, 21 (24% [15% to 34%]) tested positive at the oropharynx. Infection at both the oropharynx and genital sites was not associated with sex worker status in women. Overall, 89% and 40% of gonorrhoea in heterosexual men and women were only in the oropharynx, respectively.

CONCLUSIONS

Oropharyngeal gonorrhoea testing among heterosexual contacts of gonorrhoea may be indicated given a substantial proportion of gonorrhoea contacts are only infected at this site.

Authors+Show Affiliations

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Central Clinical School, Monash University, Melbourne, Victoria, Australia.Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Central Clinical School, Monash University, Melbourne, Victoria, Australia.Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Doherty Applied Microbial Genomics, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Central Clinical School, Monash University, Melbourne, Victoria, Australia.Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Central Clinical School, Monash University, Melbourne, Victoria, Australia.Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Central Clinical School, Monash University, Melbourne, Victoria, Australia.Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. Doherty Applied Microbial Genomics, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia. Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31517767

Citation

Chow, Eric P F., et al. "Oropharyngeal and Genital Gonorrhoea Infections Among Women and Heterosexual Men Reporting Sexual Contact With Partners With Gonorrhoea: Implication for Oropharyngeal Testing of Heterosexual Gonorrhoea Contacts." Sexually Transmitted Diseases, 2019.
Chow EPF, Chen MY, Williamson DA, et al. Oropharyngeal and genital gonorrhoea infections among women and heterosexual men reporting sexual contact with partners with gonorrhoea: implication for oropharyngeal testing of heterosexual gonorrhoea contacts. Sex Transm Dis. 2019.
Chow, E. P. F., Chen, M. Y., Williamson, D. A., Bradshaw, C. S., Vodstrcil, L. A., Trumpour, S., ... Fairley, C. K. (2019). Oropharyngeal and genital gonorrhoea infections among women and heterosexual men reporting sexual contact with partners with gonorrhoea: implication for oropharyngeal testing of heterosexual gonorrhoea contacts. Sexually Transmitted Diseases, doi:10.1097/OLQ.0000000000001068.
Chow EPF, et al. Oropharyngeal and Genital Gonorrhoea Infections Among Women and Heterosexual Men Reporting Sexual Contact With Partners With Gonorrhoea: Implication for Oropharyngeal Testing of Heterosexual Gonorrhoea Contacts. Sex Transm Dis. 2019 Sep 10; PubMed PMID: 31517767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oropharyngeal and genital gonorrhoea infections among women and heterosexual men reporting sexual contact with partners with gonorrhoea: implication for oropharyngeal testing of heterosexual gonorrhoea contacts. AU - Chow,Eric P F, AU - Chen,Marcus Y, AU - Williamson,Deborah A, AU - Bradshaw,Catriona S, AU - Vodstrcil,Lenka A, AU - Trumpour,Sabrina, AU - Howden,Benjamin P, AU - Fairley,Christopher K, Y1 - 2019/09/10/ PY - 2019/9/14/entrez JF - Sexually transmitted diseases JO - Sex Transm Dis N2 - BACKGROUND: There have been very limited studies of oropharyngeal gonorrhoea in heterosexuals. Routine screening of oropharyngeal gonorrhoea is not recommended in heterosexual contacts of gonorrhoea. The study aimed to examine oropharyngeal gonorrhoea positivity among heterosexuals reporting contact with a partner with gonorrhoea. METHODS: At the Melbourne Sexual Health Centre (MSHC), all heterosexual individuals reporting contact with sexual partners with gonorrhoea are tested for genital gonorrhoea. In May-2017, MSHC also included screening for oropharyngeal gonorrhoea in heterosexual contacts of gonorrhoea. All contacts of gonorrhoea among women and heterosexual men between May-2017 and November-2018 were reviewed. Site-specific gonorrhoea positivity was also calculated. RESULTS: 191 gonorrhoea contacts (102 heterosexual men and 89 women) were reviewed. The median age was 28 [IQR=24-33] years. The gonorrhoea positivity in males was significantly higher at the oropharynx compared to urethra (18% [95% CI: 11% to 26%] versus 2% [0% to 7%]; p<0.001); and higher at the oropharynx compared to cervico-vaginal site in women (46% [35% to 57%] versus 36% [26% to 47%]; p=0.056). Of the 100 men who did not have genital gonorrhoea, 17 (18% [10% to 26%]) tested positive at the oropharynx. Of the 55 women who did not have genital gonorrhoea, 21 (24% [15% to 34%]) tested positive at the oropharynx. Infection at both the oropharynx and genital sites was not associated with sex worker status in women. Overall, 89% and 40% of gonorrhoea in heterosexual men and women were only in the oropharynx, respectively. CONCLUSIONS: Oropharyngeal gonorrhoea testing among heterosexual contacts of gonorrhoea may be indicated given a substantial proportion of gonorrhoea contacts are only infected at this site. SN - 1537-4521 UR - https://www.unboundmedicine.com/medline/citation/31517767/Oropharyngeal_and_genital_gonorrhoea_infections_among_women_and_heterosexual_men_reporting_sexual_contact_with_partners_with_gonorrhoea:_implication_for_oropharyngeal_testing_of_heterosexual_gonorrhoea_contacts L2 - http://dx.doi.org/10.1097/OLQ.0000000000001068 DB - PRIME DP - Unbound Medicine ER -