Tags

Type your tag names separated by a space and hit enter

Regulatory roles of the miR-200 family in neurodegenerative diseases.
Biomed Pharmacother. 2019 Nov; 119:109409.BP

Abstract

Neurodegenerative diseases are chronic and progressive disorders which are not effectively treated through adopting conventional therapies. For this unmet medical need, alternative therapeutic methods including gene-based therapies are emphasized. MicroRNAs (miRNAs) are small non-coding RNAs which can regulate gene expression at the post-transcriptional level. In recent years, dysregulated miRNAs have been indicated to be implicated in the occurrence and development of neurodegenerative diseases. They are investigated as candidates for diagnostic and prognostic biomarkers, as well as therapeutic targets. The miR-200 family consists of miR-200a, -200b, -200c, -141, and -429. Numerous studies have found that miR-200 family members are associated with the pathogenesis of neurodegenerative diseases. It is reported that miR-200 family members are aberrantly expressed in several neurodegenerative diseases, participating in various cellular processes including beta-amyloid (Aβ) secretion, alpha-synuclein aggregation and DNA repair, etc. In the present review, we summarize the recent progress in the roles of miR-200 family in neurodegenerative diseases.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Fu J
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Peng L
Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China.
Tao T
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China.
Chen Y
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Li Z
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China.
Li J
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Taiping Street, Jiangyang District, Luzhou, 646000, China. Electronic address: jinglunli1@sina.com.

MeSH

HumansMicroRNAsModels, BiologicalNeurodegenerative Diseases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31518873

Citation

Fu, Jie, et al. "Regulatory Roles of the miR-200 Family in Neurodegenerative Diseases." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 119, 2019, p. 109409.
Fu J, Peng L, Tao T, et al. Regulatory roles of the miR-200 family in neurodegenerative diseases. Biomed Pharmacother. 2019;119:109409.
Fu, J., Peng, L., Tao, T., Chen, Y., Li, Z., & Li, J. (2019). Regulatory roles of the miR-200 family in neurodegenerative diseases. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 119, 109409. https://doi.org/10.1016/j.biopha.2019.109409
Fu J, et al. Regulatory Roles of the miR-200 Family in Neurodegenerative Diseases. Biomed Pharmacother. 2019;119:109409. PubMed PMID: 31518873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulatory roles of the miR-200 family in neurodegenerative diseases. AU - Fu,Jie, AU - Peng,Lilei, AU - Tao,Tao, AU - Chen,Yangmei, AU - Li,Zuoxiao, AU - Li,Jinglun, Y1 - 2019/09/10/ PY - 2019/05/23/received PY - 2019/08/24/revised PY - 2019/08/28/accepted PY - 2019/9/14/pubmed PY - 2020/2/26/medline PY - 2019/9/14/entrez KW - Biomarker KW - Neurodegenerative diseases KW - Therapy KW - miR-200 family KW - microRNAs SP - 109409 EP - 109409 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 119 N2 - Neurodegenerative diseases are chronic and progressive disorders which are not effectively treated through adopting conventional therapies. For this unmet medical need, alternative therapeutic methods including gene-based therapies are emphasized. MicroRNAs (miRNAs) are small non-coding RNAs which can regulate gene expression at the post-transcriptional level. In recent years, dysregulated miRNAs have been indicated to be implicated in the occurrence and development of neurodegenerative diseases. They are investigated as candidates for diagnostic and prognostic biomarkers, as well as therapeutic targets. The miR-200 family consists of miR-200a, -200b, -200c, -141, and -429. Numerous studies have found that miR-200 family members are associated with the pathogenesis of neurodegenerative diseases. It is reported that miR-200 family members are aberrantly expressed in several neurodegenerative diseases, participating in various cellular processes including beta-amyloid (Aβ) secretion, alpha-synuclein aggregation and DNA repair, etc. In the present review, we summarize the recent progress in the roles of miR-200 family in neurodegenerative diseases. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/31518873/Regulatory_roles_of_the_miR_200_family_in_neurodegenerative_diseases_ DB - PRIME DP - Unbound Medicine ER -