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Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study.
Environ Int 2019; 133(Pt A):105139EI

Abstract

BACKGROUND

Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated.

OBJECTIVE

To explore the associations between prenatal exposure to eleven different PFASs from two different groups (carboxylates and sulfonates) and the expression of THs and TAs in maternal and cord blood while considering maternal TA status.

METHODS

In a prospective birth cohort (the Hokkaido Study), we included 701 mother‑neonate pairs recruited in 2002-2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFASs were measured in maternal plasma obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. THs and TAs including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks), and in cord blood at birth.

RESULTS

The median levels of TgAb and TPOAb in maternal serum were 15.0 and 6.0 IU/mL, respectively. The median TgAb level in neonates was 38.0 IU/mL, and TPOAb were detected in only 12.3% of samples. Maternal FT3 level was positively associated with PFAS levels in both TA-positive and TA-negative mothers. Maternal perfluorooctanoate was inversely associated with maternal TPOAb. Among boys, some maternal PFASs were associated with higher TSH and lower FT3 levels in maternal TA-negative group, while perfluorodecanoic acid was associated with lower TSH in maternal TA-positive group. Among girls, some PFAS of mothers showed associations with lower TSH and higher FT3 in maternal TA-negative group, while perfluorododecanoic acid was associated with lower FT4 in maternal TA-positive. Maternal PFASs showed associations with boy's TgAb inversely in maternal TA-negative group and with girl's TgAb positively in maternal TA-positive group.

CONCLUSIONS

Our results suggest thyroid disrupting effects of PFAS exposure and susceptibility vary depending on maternal TA levels.

Authors+Show Affiliations

Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan; Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan.Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.Department of Public Health, School of Medicine, Juntendo University, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan; National Center for Global Health and Medicine, Japan.Center for Environmental Health and Sciences, Hokkaido University, Sapporo, Japan. Electronic address: rkishi@med.hokudai.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31518930

Citation

Itoh, Sachiko, et al. "Association Between Perfluoroalkyl Substance Exposure and Thyroid Hormone/thyroid Antibody Levels in Maternal and Cord Blood: the Hokkaido Study." Environment International, vol. 133, no. Pt A, 2019, p. 105139.
Itoh S, Araki A, Miyashita C, et al. Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study. Environ Int. 2019;133(Pt A):105139.
Itoh, S., Araki, A., Miyashita, C., Yamazaki, K., Goudarzi, H., Minatoya, M., ... Kishi, R. (2019). Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study. Environment International, 133(Pt A), p. 105139. doi:10.1016/j.envint.2019.105139.
Itoh S, et al. Association Between Perfluoroalkyl Substance Exposure and Thyroid Hormone/thyroid Antibody Levels in Maternal and Cord Blood: the Hokkaido Study. Environ Int. 2019 Sep 10;133(Pt A):105139. PubMed PMID: 31518930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study. AU - Itoh,Sachiko, AU - Araki,Atsuko, AU - Miyashita,Chihiro, AU - Yamazaki,Keiko, AU - Goudarzi,Houman, AU - Minatoya,Machiko, AU - Ait Bamai,Yu, AU - Kobayashi,Sumitaka, AU - Okada,Emiko, AU - Kashino,Ikuko, AU - Yuasa,Motoyuki, AU - Baba,Toshiaki, AU - Kishi,Reiko, Y1 - 2019/09/10/ PY - 2019/01/11/received PY - 2019/08/27/revised PY - 2019/08/27/accepted PY - 2019/9/14/pubmed PY - 2019/9/14/medline PY - 2019/9/14/entrez KW - Birth cohort KW - Perfluoroalkyl substances KW - Prenatal exposure KW - Thyroid antibodies KW - Thyroid hormones SP - 105139 EP - 105139 JF - Environment international JO - Environ Int VL - 133 IS - Pt A N2 - BACKGROUND: Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated. OBJECTIVE: To explore the associations between prenatal exposure to eleven different PFASs from two different groups (carboxylates and sulfonates) and the expression of THs and TAs in maternal and cord blood while considering maternal TA status. METHODS: In a prospective birth cohort (the Hokkaido Study), we included 701 mother‑neonate pairs recruited in 2002-2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFASs were measured in maternal plasma obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. THs and TAs including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks), and in cord blood at birth. RESULTS: The median levels of TgAb and TPOAb in maternal serum were 15.0 and 6.0 IU/mL, respectively. The median TgAb level in neonates was 38.0 IU/mL, and TPOAb were detected in only 12.3% of samples. Maternal FT3 level was positively associated with PFAS levels in both TA-positive and TA-negative mothers. Maternal perfluorooctanoate was inversely associated with maternal TPOAb. Among boys, some maternal PFASs were associated with higher TSH and lower FT3 levels in maternal TA-negative group, while perfluorodecanoic acid was associated with lower TSH in maternal TA-positive group. Among girls, some PFAS of mothers showed associations with lower TSH and higher FT3 in maternal TA-negative group, while perfluorododecanoic acid was associated with lower FT4 in maternal TA-positive. Maternal PFASs showed associations with boy's TgAb inversely in maternal TA-negative group and with girl's TgAb positively in maternal TA-positive group. CONCLUSIONS: Our results suggest thyroid disrupting effects of PFAS exposure and susceptibility vary depending on maternal TA levels. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/31518930/Association_between_perfluoroalkyl_substance_exposure_and_thyroid_hormone/thyroid_antibody_levels_in_maternal_and_cord_blood:_The_Hokkaido_Study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(19)30119-9 DB - PRIME DP - Unbound Medicine ER -