Tags

Type your tag names separated by a space and hit enter

Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review.
Anticancer Res 2019; 39(9):5185-5194AR

Abstract

BACKGROUND

Schwannoma is most often grown on the trunk, upper and lower extremities, and head and neck, but rarely on the foot. This study aimed to reveal clinical presentations, histopathology and treatment options for schwannoma of the foot.

MATERIALS AND METHODS

Seven schwannomas out of 174 soft-tissue tumors on the foot and ankle were retrieved from our Institute in a 3-year period, and 42 schwannomas on the foot and ankle in the literature in a 30-year period were reviewed.

RESULTS

The incidence of schwannoma of foot was found to be 4.0%. The patient age ranged from 8 to 84 years, with a mean of 47.4 years. More than 80% of tumors were located on the ankle, heel and plantar aspect. Overall, 77.6% of patients complained about a painful mass. Magnetic resonance imaging revealed a well-circumscribed, round or ovoid mass with iso-intensity signal compared with surrounding neuromuscular tissues on T1-weighted images and hyper-intensity signal on T2. Forty-eight out of 49 patients were treated with surgical excision or enucleation without recurrence in follow-up from 2 months to 4 years. Histologically, schwannoma was composed of hypercellular Antoni A zone with palisaded spindle cells with strong immunostaining for S-100 and hypocellular Antoni B zone with vascularization in myxoid stroma.

CONCLUSION

Schwannoma of the foot and ankle is a rare, painful, indurated tumor. Magnetic resonance imaging reveals the location, size, texture and relationships with surrounding neuromuscular structures. Surgical excision is the primary treatment option with excellent outcome.

Authors+Show Affiliations

Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A. xhao@footandankle-usa.com gmirkin@footandankle-usa.com.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD, U.S.A.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A.Foot and Ankle Specialists of the Mid-Atlantic, LLC., Rockville, MD, U.S.A. xhao@footandankle-usa.com gmirkin@footandankle-usa.com.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

31519632

Citation

Hao, Xingpei, et al. "Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review." Anticancer Research, vol. 39, no. 9, 2019, pp. 5185-5194.
Hao X, Levine D, Yim J, et al. Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review. Anticancer Res. 2019;39(9):5185-5194.
Hao, X., Levine, D., Yim, J., Qi, C., Firestone, L., Beiser, I., ... Mirkin, G. (2019). Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review. Anticancer Research, 39(9), pp. 5185-5194. doi:10.21873/anticanres.13715.
Hao X, et al. Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review. Anticancer Res. 2019;39(9):5185-5194. PubMed PMID: 31519632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review. AU - Hao,Xingpei, AU - Levine,David, AU - Yim,Joon, AU - Qi,Chenfeng, AU - Firestone,Lee, AU - Beiser,Ian, AU - Leone,Enzo, AU - Woelffer,Kirk, AU - Mirkin,Gene, PY - 2019/07/23/received PY - 2019/08/08/revised PY - 2019/08/09/accepted PY - 2019/9/15/entrez PY - 2019/9/15/pubmed PY - 2019/9/27/medline KW - Ankle KW - MRI KW - excision KW - foot KW - pathology KW - schwannoma SP - 5185 EP - 5194 JF - Anticancer research JO - Anticancer Res. VL - 39 IS - 9 N2 - BACKGROUND: Schwannoma is most often grown on the trunk, upper and lower extremities, and head and neck, but rarely on the foot. This study aimed to reveal clinical presentations, histopathology and treatment options for schwannoma of the foot. MATERIALS AND METHODS: Seven schwannomas out of 174 soft-tissue tumors on the foot and ankle were retrieved from our Institute in a 3-year period, and 42 schwannomas on the foot and ankle in the literature in a 30-year period were reviewed. RESULTS: The incidence of schwannoma of foot was found to be 4.0%. The patient age ranged from 8 to 84 years, with a mean of 47.4 years. More than 80% of tumors were located on the ankle, heel and plantar aspect. Overall, 77.6% of patients complained about a painful mass. Magnetic resonance imaging revealed a well-circumscribed, round or ovoid mass with iso-intensity signal compared with surrounding neuromuscular tissues on T1-weighted images and hyper-intensity signal on T2. Forty-eight out of 49 patients were treated with surgical excision or enucleation without recurrence in follow-up from 2 months to 4 years. Histologically, schwannoma was composed of hypercellular Antoni A zone with palisaded spindle cells with strong immunostaining for S-100 and hypocellular Antoni B zone with vascularization in myxoid stroma. CONCLUSION: Schwannoma of the foot and ankle is a rare, painful, indurated tumor. Magnetic resonance imaging reveals the location, size, texture and relationships with surrounding neuromuscular structures. Surgical excision is the primary treatment option with excellent outcome. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/31519632/Schwannoma_of_Foot_and_Ankle:_Seven_Case_Reports_and_Literature_Review L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=31519632 DB - PRIME DP - Unbound Medicine ER -