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Risk factors for unsuccessful atropine therapy in hypertrophic pyloric stenosis.

Abstract

BACKGROUND

Intravenous atropine (IA) for infantile hypertrophic pyloric stenosis (IHPS) is a good alternative to pyloromyotomy but has not been broadly accepted. The lower success rate is one of the greatest disadvantages of IA. We aimed to investigate the risk factors for unsuccessful results following IA for IHPS.

METHODS

Medical records of patients with IHPS who were admitted to our institution between 2002 and 2016 and were initially administered atropine sulfate were retrospectively reviewed. Atropine was given intravenously (0.1 mg/kg/day in 8 divided doses). Oral feeding of milk was started with a small amount and increased in a stepwise fashion to full feed. IA therapy was judged unsuccessful from the presence of projectile vomiting more than three times a day or intolerance to a predetermined amount of milk.

RESULTS

Among the 48 patients with IHPS, 33 patients were successfully treated with IA therapy and 15 patients needed surgical intervention. Univariate analyses showed that the risk factors for unsuccessful IA therapy were younger age, lower body weight, and shorter duration of symptoms before diagnosis. Multivariate analysis showed that an age at diagnosis of <30 days was the only significant risk factor for unsuccessful IA therapy (odds ratio 5.7, p = 0.03).

CONCLUSIONS

An age at diagnosis <30 days was shown to be a risk factor for unsuccessful IA therapy in IHPS. This might be considered when IA therapy is applied to neonates with IHPS.

Authors+Show Affiliations

Department of Pediatric Surgery, Kimitsu Chuo Hospital, 1010 Sakurai, Kisarazu City, Chiba, Japan. Department of Pediatric Surgery, Chiba Children's Hospital, Japan.Department of Pediatric Surgery, Kimitsu Chuo Hospital, 1010 Sakurai, Kisarazu City, Chiba, Japan. Department of Pediatric Surgery, Tokyo Women's University Yachiyo Medical Center, Japan.Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba, Japan.Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba, Japan.Department of Pediatric Surgery, Kimitsu Chuo Hospital, 1010 Sakurai, Kisarazu City, Chiba, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31520503

Citation

Ono, Sachie, et al. "Risk Factors for Unsuccessful Atropine Therapy in Hypertrophic Pyloric Stenosis." Pediatrics International : Official Journal of the Japan Pediatric Society, 2019.
Ono S, Takenouchi A, Terui K, et al. Risk factors for unsuccessful atropine therapy in hypertrophic pyloric stenosis. Pediatr Int. 2019.
Ono, S., Takenouchi, A., Terui, K., Yoshida, H., & Terui, E. (2019). Risk factors for unsuccessful atropine therapy in hypertrophic pyloric stenosis. Pediatrics International : Official Journal of the Japan Pediatric Society, doi:10.1111/ped.14009.
Ono S, et al. Risk Factors for Unsuccessful Atropine Therapy in Hypertrophic Pyloric Stenosis. Pediatr Int. 2019 Sep 14; PubMed PMID: 31520503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for unsuccessful atropine therapy in hypertrophic pyloric stenosis. AU - Ono,Sachie, AU - Takenouchi,Ayako, AU - Terui,Keita, AU - Yoshida,Hideo, AU - Terui,Elena, Y1 - 2019/09/14/ PY - 2019/9/15/entrez KW - infantile hypertrophic pyloric stenosis KW - intravenous atropine therapy KW - medical treatment KW - risk factor JF - Pediatrics international : official journal of the Japan Pediatric Society JO - Pediatr Int N2 - BACKGROUND: Intravenous atropine (IA) for infantile hypertrophic pyloric stenosis (IHPS) is a good alternative to pyloromyotomy but has not been broadly accepted. The lower success rate is one of the greatest disadvantages of IA. We aimed to investigate the risk factors for unsuccessful results following IA for IHPS. METHODS: Medical records of patients with IHPS who were admitted to our institution between 2002 and 2016 and were initially administered atropine sulfate were retrospectively reviewed. Atropine was given intravenously (0.1 mg/kg/day in 8 divided doses). Oral feeding of milk was started with a small amount and increased in a stepwise fashion to full feed. IA therapy was judged unsuccessful from the presence of projectile vomiting more than three times a day or intolerance to a predetermined amount of milk. RESULTS: Among the 48 patients with IHPS, 33 patients were successfully treated with IA therapy and 15 patients needed surgical intervention. Univariate analyses showed that the risk factors for unsuccessful IA therapy were younger age, lower body weight, and shorter duration of symptoms before diagnosis. Multivariate analysis showed that an age at diagnosis of <30 days was the only significant risk factor for unsuccessful IA therapy (odds ratio 5.7, p = 0.03). CONCLUSIONS: An age at diagnosis <30 days was shown to be a risk factor for unsuccessful IA therapy in IHPS. This might be considered when IA therapy is applied to neonates with IHPS. SN - 1442-200X UR - https://www.unboundmedicine.com/medline/citation/31520503/Risk_factors_for_unsuccessful_atropine_therapy_in_hypertrophic_pyloric_stenosis L2 - https://doi.org/10.1111/ped.14009 DB - PRIME DP - Unbound Medicine ER -