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Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Rev Neurol (Paris). 2019 Dec; 175(10):724-741.RN

Abstract

The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic acid from corn oil, sunflower oil and peanut oil. Diets rich in ω-6 fatty acids inhibit the formation of healthier ω-3 fatty acids. The deleterious effects on lipid metabolism of excessive intake of carbohydrates, in particular high-fructose corn syrup and artificial sweeteners, are explained. The critical role of the ω-3 fatty acid docosahexaenoic acid in the developing and aging brain and in Alzheimer disease is addressed. Nutritional epidemiology studies, prospective population-based surveys, and clinical trials confirm the salutary effects of fish consumption on prevention of coronary artery disease, stroke and dementia. Recent recommendations on fish consumption by pregnant women and potential mercury toxicity are reviewed. The polyphenols and flavonoids of plant origin play a critical role in the Mediterranean diet, because of their antioxidant and anti-inflammatory properties of benefit in type-2 diabetes mellitus, cardiovascular disease, stroke and cancer prevention. Polyphenols from fruits and vegetables modulate tau hyperphosphorylation and beta amyloid aggregation in animal models of Alzheimer disease. From the public health viewpoint worldwide the daily consumption of fruits and vegetables has become the main tool for prevention of cardiovascular disease and stroke. We review the important dietary role of cereal grains in prevention of coronary disease and stroke. Polyphenols from grapes, wine and alcoholic beverages are discussed, in particular their effects on coagulation. The mechanisms of action of probiotics and vitamins are also included.

Authors+Show Affiliations

Methodist Neurological Institute and Research Institute, Houston Methodist Hospital, Texas, USA; Weill Cornell Medical College, Cornell University, New York, NY, USA. Electronic address: gcroman@houstonmethodist.org.Weill Cornell Medical College, Cornell University, New York, NY, USA; Department of Internal Medicine and Research Institute, Houston Methodist Hospital, Texas, USA.Methodist Neurological Institute and Research Institute, Houston Methodist Hospital, Texas, USA; Weill Cornell Medical College, Cornell University, New York, NY, USA; University of Strasbourg, 22, rue Rene Descartes, Strasbourg, France.University of Houston, Houston, Texas, USA.University of Strasbourg, 22, rue Rene Descartes, Strasbourg, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31521398

Citation

Román, G C., et al. "Mediterranean Diet: the Role of Long-chain Ω-3 Fatty Acids in Fish; Polyphenols in Fruits, Vegetables, Cereals, Coffee, Tea, Cacao and Wine; Probiotics and Vitamins in Prevention of Stroke, Age-related Cognitive Decline, and Alzheimer Disease." Revue Neurologique, vol. 175, no. 10, 2019, pp. 724-741.
Román GC, Jackson RE, Gadhia R, et al. Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Rev Neurol (Paris). 2019;175(10):724-741.
Román, G. C., Jackson, R. E., Gadhia, R., Román, A. N., & Reis, J. (2019). Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Revue Neurologique, 175(10), 724-741. https://doi.org/10.1016/j.neurol.2019.08.005
Román GC, et al. Mediterranean Diet: the Role of Long-chain Ω-3 Fatty Acids in Fish; Polyphenols in Fruits, Vegetables, Cereals, Coffee, Tea, Cacao and Wine; Probiotics and Vitamins in Prevention of Stroke, Age-related Cognitive Decline, and Alzheimer Disease. Rev Neurol (Paris). 2019;175(10):724-741. PubMed PMID: 31521398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. AU - Román,G C, AU - Jackson,R E, AU - Gadhia,R, AU - Román,A N, AU - Reis,J, Y1 - 2019/09/11/ PY - 2019/08/09/received PY - 2019/08/28/accepted PY - 2019/9/16/pubmed PY - 2020/6/2/medline PY - 2019/9/16/entrez KW - Alzheimer disease KW - B-vitamins KW - Cacao KW - Cardiovascular disease KW - Cereals KW - Cerebrovascular disease KW - Cobalamin KW - Coffee KW - DASH diet KW - Fish consumption KW - Fruits KW - Legumes KW - Mediterranean diet KW - Omega-3 fatty acids KW - Polyphenols KW - Prevention KW - Probiotics KW - Stroke KW - Tea KW - Vascular cognitive impairment KW - Vascular dementia KW - Vegetables KW - Wine KW - Yogurt SP - 724 EP - 741 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 175 IS - 10 N2 - The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic acid from corn oil, sunflower oil and peanut oil. Diets rich in ω-6 fatty acids inhibit the formation of healthier ω-3 fatty acids. The deleterious effects on lipid metabolism of excessive intake of carbohydrates, in particular high-fructose corn syrup and artificial sweeteners, are explained. The critical role of the ω-3 fatty acid docosahexaenoic acid in the developing and aging brain and in Alzheimer disease is addressed. Nutritional epidemiology studies, prospective population-based surveys, and clinical trials confirm the salutary effects of fish consumption on prevention of coronary artery disease, stroke and dementia. Recent recommendations on fish consumption by pregnant women and potential mercury toxicity are reviewed. The polyphenols and flavonoids of plant origin play a critical role in the Mediterranean diet, because of their antioxidant and anti-inflammatory properties of benefit in type-2 diabetes mellitus, cardiovascular disease, stroke and cancer prevention. Polyphenols from fruits and vegetables modulate tau hyperphosphorylation and beta amyloid aggregation in animal models of Alzheimer disease. From the public health viewpoint worldwide the daily consumption of fruits and vegetables has become the main tool for prevention of cardiovascular disease and stroke. We review the important dietary role of cereal grains in prevention of coronary disease and stroke. Polyphenols from grapes, wine and alcoholic beverages are discussed, in particular their effects on coagulation. The mechanisms of action of probiotics and vitamins are also included. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/31521398/Mediterranean_diet:_The_role_of_long_chain_ω_3_fatty_acids_in_fish DB - PRIME DP - Unbound Medicine ER -