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Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1.
Best Pract Res Clin Endocrinol Metab. 2019 10; 33(5):101318.BP

Abstract

About 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymphatic metastases, the survival is generally good with an aggressive course of disease in only about 20% of patients. Symptoms can be controlled medically. The indication, timing, type, and extent of surgery are highly controversial and are discussed in detail in this article by a thorough and critical review of literature. More radical procedures, like partial pancreaticoduodenectomy, are weighed against less aggressive local excision of gastrinomas and the pros and cons of both approaches are discussed in terms of long-term morbidity, biochemical cure, and survival.

Authors+Show Affiliations

Department of Visceral, Thoracic, and Vascular Surgery, Philipps University Marburg, Baldingerstr, 35037 Marburg, Germany. Electronic address: albersm@med.uni-marburg.de.Department of Visceral, Thoracic, and Vascular Surgery, Philipps University Marburg, Baldingerstr, 35037 Marburg, Germany.Department of Visceral, Thoracic, and Vascular Surgery, Philipps University Marburg, Baldingerstr, 35037 Marburg, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31521501

Citation

Albers, Max B., et al. "Contemporary Surgical Management of the Zollinger-Ellison Syndrome in Multiple Endocrine Neoplasia Type 1." Best Practice & Research. Clinical Endocrinology & Metabolism, vol. 33, no. 5, 2019, p. 101318.
Albers MB, Manoharan J, Bartsch DK. Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1. Best Pract Res Clin Endocrinol Metab. 2019;33(5):101318.
Albers, M. B., Manoharan, J., & Bartsch, D. K. (2019). Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1. Best Practice & Research. Clinical Endocrinology & Metabolism, 33(5), 101318. https://doi.org/10.1016/j.beem.2019.101318
Albers MB, Manoharan J, Bartsch DK. Contemporary Surgical Management of the Zollinger-Ellison Syndrome in Multiple Endocrine Neoplasia Type 1. Best Pract Res Clin Endocrinol Metab. 2019;33(5):101318. PubMed PMID: 31521501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1. AU - Albers,Max B, AU - Manoharan,Jerena, AU - Bartsch,Detlef K, Y1 - 2019/08/31/ PY - 2019/9/16/pubmed PY - 2020/3/27/medline PY - 2019/9/16/entrez KW - Zollinger-Ellison-syndrome KW - multiple endocrine neoplasia type 1 KW - surgery SP - 101318 EP - 101318 JF - Best practice & research. Clinical endocrinology & metabolism JO - Best Pract. Res. Clin. Endocrinol. Metab. VL - 33 IS - 5 N2 - About 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymphatic metastases, the survival is generally good with an aggressive course of disease in only about 20% of patients. Symptoms can be controlled medically. The indication, timing, type, and extent of surgery are highly controversial and are discussed in detail in this article by a thorough and critical review of literature. More radical procedures, like partial pancreaticoduodenectomy, are weighed against less aggressive local excision of gastrinomas and the pros and cons of both approaches are discussed in terms of long-term morbidity, biochemical cure, and survival. SN - 1878-1594 UR - https://www.unboundmedicine.com/medline/citation/31521501/Contemporary_surgical_management_of_the_Zollinger-Ellison_syndrome_in_multiple_endocrine_neoplasia_type_1 L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-690X(19)30069-7 DB - PRIME DP - Unbound Medicine ER -