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Association of urinary bisphenols and triclosan with thyroid function during early pregnancy.
Environ Int 2019; 133(Pt A):105123EI

Abstract

BACKGROUND

Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal thyroid function can result in adverse pregnancy and child developmental outcomes, there is still uncertainty whether bisphenols or triclosan can interfere with thyroid function during pregnancy.

OBJECTIVES

We aimed to investigate the association of urinary bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF) and triclosan with early pregnancy thyroid function.

METHODS

This study was embedded in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (SELMA), a population-based prospective pregnancy cohort. In total, 1996 participants were included in the current study. Maternal urinary concentrations of three bisphenols and triclosan, collected at median (95% range) 10 (6-14) weeks of pregnancy as well as serum concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were measured.

RESULTS

Higher BPA levels were associated with lower TT4 concentrations (non-monotonic, P = 0.03), a lower FT4/FT3 ratio (β [SE] -0.02 [0.01], P = 0.03) and a lower TT4/TT3 ratio (β [SE] -0.73 [0.27], P = 0.008). Higher BPF levels were associated with a higher FT3 (β [SE] 0.01 [0.007], P = 0.04). There were no associations between other bisphenols or triclosan and absolute TSH, (F)T4 or (F)T3 concentrations. The association of BPA with thyroid function differed with gestational age. The negative association of BPA with FT4/FT3 and TT4/TT3 ratios was only apparent in early but not late gestation (P for interaction: 0.003, 0.008, respectively).

CONCLUSION

These human data during pregnancy substantiate experimental findings suggesting that BPA could potentially affect thyroid function and deiodinase activities in early gestation.

Authors+Show Affiliations

Academic Center for Thyroid Diseases, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands.Department of Environmental Science and Analytical Chemistry, Stockholm University, Sweden.Academic Center for Thyroid Diseases, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands.Institute of Environment, Health and Societies, Brunel University, London, Uxbridge, UK.Division of Occupational and Environmental Medicine, Lund University, 22363 Lund, Sweden.Laboratoire d'Evolution des Régulations Endocriniennes, Muséum National d'Histoire Naturelle, 57 Rue Cuvier, 75005 Paris, France.Division of Public Health Sciences, Karlstad University, Karlstad, Sweden; Icahn School of Medicine at Mount Sinai, New York City, NY, USA.Academic Center for Thyroid Diseases, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 15, 3051 GE Rotterdam, the Netherlands. Electronic address: t.korevaar@erasmusmc.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31521814

Citation

Derakhshan, Arash, et al. "Association of Urinary Bisphenols and Triclosan With Thyroid Function During Early Pregnancy." Environment International, vol. 133, no. Pt A, 2019, p. 105123.
Derakhshan A, Shu H, Peeters RP, et al. Association of urinary bisphenols and triclosan with thyroid function during early pregnancy. Environ Int. 2019;133(Pt A):105123.
Derakhshan, A., Shu, H., Peeters, R. P., Kortenkamp, A., Lindh, C. H., Demeneix, B., ... Korevaar, T. I. M. (2019). Association of urinary bisphenols and triclosan with thyroid function during early pregnancy. Environment International, 133(Pt A), p. 105123. doi:10.1016/j.envint.2019.105123.
Derakhshan A, et al. Association of Urinary Bisphenols and Triclosan With Thyroid Function During Early Pregnancy. Environ Int. 2019 Sep 12;133(Pt A):105123. PubMed PMID: 31521814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of urinary bisphenols and triclosan with thyroid function during early pregnancy. AU - Derakhshan,Arash, AU - Shu,Huan, AU - Peeters,Robin P, AU - Kortenkamp,Andreas, AU - Lindh,Christian H, AU - Demeneix,Barbara, AU - Bornehag,Carl-Gustaf, AU - Korevaar,Tim I M, Y1 - 2019/09/12/ PY - 2019/06/07/received PY - 2019/08/20/revised PY - 2019/08/23/accepted PY - 2019/9/16/pubmed PY - 2019/9/16/medline PY - 2019/9/16/entrez KW - Bisphenol KW - Pregnancy KW - Thyroid function KW - Triclosan, Endocrine disruption SP - 105123 EP - 105123 JF - Environment international JO - Environ Int VL - 133 IS - Pt A N2 - BACKGROUND: Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal thyroid function can result in adverse pregnancy and child developmental outcomes, there is still uncertainty whether bisphenols or triclosan can interfere with thyroid function during pregnancy. OBJECTIVES: We aimed to investigate the association of urinary bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF) and triclosan with early pregnancy thyroid function. METHODS: This study was embedded in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (SELMA), a population-based prospective pregnancy cohort. In total, 1996 participants were included in the current study. Maternal urinary concentrations of three bisphenols and triclosan, collected at median (95% range) 10 (6-14) weeks of pregnancy as well as serum concentrations of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were measured. RESULTS: Higher BPA levels were associated with lower TT4 concentrations (non-monotonic, P = 0.03), a lower FT4/FT3 ratio (β [SE] -0.02 [0.01], P = 0.03) and a lower TT4/TT3 ratio (β [SE] -0.73 [0.27], P = 0.008). Higher BPF levels were associated with a higher FT3 (β [SE] 0.01 [0.007], P = 0.04). There were no associations between other bisphenols or triclosan and absolute TSH, (F)T4 or (F)T3 concentrations. The association of BPA with thyroid function differed with gestational age. The negative association of BPA with FT4/FT3 and TT4/TT3 ratios was only apparent in early but not late gestation (P for interaction: 0.003, 0.008, respectively). CONCLUSION: These human data during pregnancy substantiate experimental findings suggesting that BPA could potentially affect thyroid function and deiodinase activities in early gestation. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/31521814/Association_of_urinary_bisphenols_and_triclosan_with_thyroid_function_during_early_pregnancy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(19)31936-1 DB - PRIME DP - Unbound Medicine ER -