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Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury: a semi-automated image processing technique.

Abstract

Although intramyocardial hemorrhage (IMH) is a poor prognostic factor caused by ischemia reperfusion injury, little evidence is available regarding the association between IMH volume and biomarkers. In the present study, we measured IMH volume using three-dimensional (3D) T1-weighted magnetic resonance imaging (T1-MRI) and investigated its association with biomarkers. Moreover, the accuracy of semi-automatic measurement of IMH volume was validated. We retrospectively enrolled 33 consecutive patients (mean age 67 ± 11 years) who underwent cardiac MRI after reperfusion therapy for acute myocardial infarction. IMH was observed in 4 patients (12.1%). Receiver operating characteristics (ROC) analysis of creatine kinase (CK) and CK-muscle/brain (CK-MB) tests for detecting IMH were performed. IMH volume measured using semi-automatic methods by a 2 standard deviation (SD) threshold was compared to manual measurements using the Spearman's correlation coefficient (ρ) and Bland-Altman analyses. ROC analysis revealed optimal cutoff values of CK: 2460 IU/l and CK-MB: 231 IU/l (area under the curve: 0.95 and 0.91; sensitivity: 86% and 79%; specificity: 100% for both). IMH volume with the 2SD threshold correlated with that of the manual measurement [5.84 g (3.30 to 9.00) g vs. 8.07 g (5.37 to 9.33); ρ: 0.85, p < 0.01; bias (limit of agreement): - 0.01 g (- 0.51 to 0.49); intraclass correlation coefficients 0.84 (0.75 to 0.90)]. Our findings could help identify the risk of IMH after reperfusion therapy with biomarkers. 3D T1-MRI can semi-automatically provide accurate IMH volume without being time-consuming.

Authors+Show Affiliations

Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Japan.Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan. k-mstr@hs.med.kyushu-u.ac.jp.Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Japan.Oita Prefectural Hospital, Oita, Japan.Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Japan.Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Japan.Fukuokaken Saiseikai Futsukaichi Hospital, Fukuoka, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31522312

Citation

Arai, Hideo, et al. "Quantification of Intramyocardial Hemorrhage Volume Using Magnetic Resonance Imaging With Three-dimensional T1-weighted Sequence in Patients With Ischemia-reperfusion Injury: a Semi-automated Image Processing Technique." The International Journal of Cardiovascular Imaging, 2019.
Arai H, Kawakubo M, Abe K, et al. Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury: a semi-automated image processing technique. Int J Cardiovasc Imaging. 2019.
Arai, H., Kawakubo, M., Abe, K., Hatashima, H., Sanui, K., Nishimura, H., & Kadokami, T. (2019). Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury: a semi-automated image processing technique. The International Journal of Cardiovascular Imaging, doi:10.1007/s10554-019-01697-4.
Arai H, et al. Quantification of Intramyocardial Hemorrhage Volume Using Magnetic Resonance Imaging With Three-dimensional T1-weighted Sequence in Patients With Ischemia-reperfusion Injury: a Semi-automated Image Processing Technique. Int J Cardiovasc Imaging. 2019 Sep 14; PubMed PMID: 31522312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury: a semi-automated image processing technique. AU - Arai,Hideo, AU - Kawakubo,Masateru, AU - Abe,Ko, AU - Hatashima,Hikaru, AU - Sanui,Kenichi, AU - Nishimura,Hiroshi, AU - Kadokami,Toshiaki, Y1 - 2019/09/14/ PY - 2019/07/09/received PY - 2019/09/08/accepted PY - 2019/9/16/entrez PY - 2019/9/16/pubmed PY - 2019/9/16/medline KW - Acute myocardial infarction KW - Biomarker KW - Intramyocardial hemorrhage KW - Magnetic resonance imaging KW - Quantification KW - Semi-automated threshold method JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging N2 - Although intramyocardial hemorrhage (IMH) is a poor prognostic factor caused by ischemia reperfusion injury, little evidence is available regarding the association between IMH volume and biomarkers. In the present study, we measured IMH volume using three-dimensional (3D) T1-weighted magnetic resonance imaging (T1-MRI) and investigated its association with biomarkers. Moreover, the accuracy of semi-automatic measurement of IMH volume was validated. We retrospectively enrolled 33 consecutive patients (mean age 67 ± 11 years) who underwent cardiac MRI after reperfusion therapy for acute myocardial infarction. IMH was observed in 4 patients (12.1%). Receiver operating characteristics (ROC) analysis of creatine kinase (CK) and CK-muscle/brain (CK-MB) tests for detecting IMH were performed. IMH volume measured using semi-automatic methods by a 2 standard deviation (SD) threshold was compared to manual measurements using the Spearman's correlation coefficient (ρ) and Bland-Altman analyses. ROC analysis revealed optimal cutoff values of CK: 2460 IU/l and CK-MB: 231 IU/l (area under the curve: 0.95 and 0.91; sensitivity: 86% and 79%; specificity: 100% for both). IMH volume with the 2SD threshold correlated with that of the manual measurement [5.84 g (3.30 to 9.00) g vs. 8.07 g (5.37 to 9.33); ρ: 0.85, p < 0.01; bias (limit of agreement): - 0.01 g (- 0.51 to 0.49); intraclass correlation coefficients 0.84 (0.75 to 0.90)]. Our findings could help identify the risk of IMH after reperfusion therapy with biomarkers. 3D T1-MRI can semi-automatically provide accurate IMH volume without being time-consuming. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/31522312/Quantification_of_intramyocardial_hemorrhage_volume_using_magnetic_resonance_imaging_with_three-dimensional_T1-weighted_sequence_in_patients_with_ischemia-reperfusion_injury:_a_semi-automated_image_processing_technique L2 - https://doi.org/10.1007/s10554-019-01697-4 DB - PRIME DP - Unbound Medicine ER -