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Necrotizing myositis: highlighting the hidden depths - case series and review of the literature.
ANZ J Surg 2019AJ

Abstract

BACKGROUND

Necrotizing myositis (NM) is a life-threatening emergency. It causes focal muscle necrosis without abscess formation or extensive involvement of the overlying fascia and soft tissue. It is a clinical diagnosis requiring a high index of clinical suspicion. Usual presentation can readily be mistaken to represent more benign pathologies such as muscular injury, viral myopathy or deep venous thrombosis. The clinical course following initial misdiagnosis is rapid deterioration into profound sepsis and progressive multiorgan failure. Prompt treatment is associated with favourable outcomes, but early diagnosis is challenging due to initial absence of cutaneous signs and symptoms. Delayed referral to surgeons with appropriate expertise results in higher morbidity and mortality. The cornerstones to treatment are complete surgical debridement, intensive care management and accurate antimicrobial therapy.

METHODS

We report four cases of NM demonstrating classical scenarios of initial misdiagnosis, delays in referral and review by an experienced surgeon. A review of the current literature to aid with overall management is also included.

RESULTS

Review of literature that revealed the most common presentation was antecedent prodromal flu-like symptoms followed by rapidly progressing focal muscle pain. Patients were initially misdiagnosed followed by rapid deterioration into profound sepsis before surgical opinion was obtained.

CONCLUSION

NM is a rare and potentially fatal disease that must be considered in the differential diagnoses of the young, healthy patient with acute limb pain and fever. A high index of suspicion will facilitate earlier management and reduce morbidity and mortality.

Authors+Show Affiliations

Department of Plastic Surgery, Fiona Stanley Hospital, Perth, Western Australia, Australia.Department of Plastic Surgery, Fiona Stanley Hospital, Perth, Western Australia, Australia.Department of Plastic Surgery, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31522470

Citation

Khanna, Anmol, et al. "Necrotizing Myositis: Highlighting the Hidden Depths - Case Series and Review of the Literature." ANZ Journal of Surgery, 2019.
Khanna A, Gurusinghe D, Taylor D. Necrotizing myositis: highlighting the hidden depths - case series and review of the literature. ANZ J Surg. 2019.
Khanna, A., Gurusinghe, D., & Taylor, D. (2019). Necrotizing myositis: highlighting the hidden depths - case series and review of the literature. ANZ Journal of Surgery, doi:10.1111/ans.15429.
Khanna A, Gurusinghe D, Taylor D. Necrotizing Myositis: Highlighting the Hidden Depths - Case Series and Review of the Literature. ANZ J Surg. 2019 Sep 14; PubMed PMID: 31522470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrotizing myositis: highlighting the hidden depths - case series and review of the literature. AU - Khanna,Anmol, AU - Gurusinghe,Dilnath, AU - Taylor,Duncan, Y1 - 2019/09/14/ PY - 2018/11/15/received PY - 2019/07/23/revised PY - 2019/07/31/accepted PY - 2019/9/16/entrez PY - 2019/9/16/pubmed PY - 2019/9/16/medline KW - bacterial myositis KW - muscle necrosis KW - necrotizing myositis KW - streptococcal myositis JF - ANZ journal of surgery JO - ANZ J Surg N2 - BACKGROUND: Necrotizing myositis (NM) is a life-threatening emergency. It causes focal muscle necrosis without abscess formation or extensive involvement of the overlying fascia and soft tissue. It is a clinical diagnosis requiring a high index of clinical suspicion. Usual presentation can readily be mistaken to represent more benign pathologies such as muscular injury, viral myopathy or deep venous thrombosis. The clinical course following initial misdiagnosis is rapid deterioration into profound sepsis and progressive multiorgan failure. Prompt treatment is associated with favourable outcomes, but early diagnosis is challenging due to initial absence of cutaneous signs and symptoms. Delayed referral to surgeons with appropriate expertise results in higher morbidity and mortality. The cornerstones to treatment are complete surgical debridement, intensive care management and accurate antimicrobial therapy. METHODS: We report four cases of NM demonstrating classical scenarios of initial misdiagnosis, delays in referral and review by an experienced surgeon. A review of the current literature to aid with overall management is also included. RESULTS: Review of literature that revealed the most common presentation was antecedent prodromal flu-like symptoms followed by rapidly progressing focal muscle pain. Patients were initially misdiagnosed followed by rapid deterioration into profound sepsis before surgical opinion was obtained. CONCLUSION: NM is a rare and potentially fatal disease that must be considered in the differential diagnoses of the young, healthy patient with acute limb pain and fever. A high index of suspicion will facilitate earlier management and reduce morbidity and mortality. SN - 1445-2197 UR - https://www.unboundmedicine.com/medline/citation/31522470/Necrotizing_myositis:_highlighting_the_hidden_depths_-_case_series_and_review_of_the_literature L2 - https://doi.org/10.1111/ans.15429 DB - PRIME DP - Unbound Medicine ER -